Breast cancer in previously thyroidectomized patients: which thyroid disorders are a risk factor?

breast cancer thyroid autoantibodies thyroid autoimmunity thyroid carcinoma thyroid disorders thyroid dysfunctions

Journal

Future science OA
ISSN: 2056-5623
Titre abrégé: Future Sci OA
Pays: England
ID NLM: 101665030

Informations de publication

Date de publication:
29 Mar 2021
Historique:
entrez: 28 5 2021
pubmed: 29 5 2021
medline: 29 5 2021
Statut: epublish

Résumé

The aim of this study was to evaluate whether there are thyroid diseases in which breast cancer will appear later as well as the role of autoimmunity. This was a retrospective observational study. A total of 410 females (thyroid surgery and later breast cancer) and 524 females (thyroid surgery only) were compared with regard to pathological thyroid findings, thyroid hormones, thyroid autoimmunity and type of breast cancer. Thyroid autoimmunity, especially antithyroid peroxidase antibodies, significantly increased the risk of breast cancer (p < 0.01); however, this was not true for other thyroid diseases, including thyroid cancer. No variant of breast cancer was predominant, and only thyroid autoimmunity was associated with the risk of breast cancer. Further research is needed to explain the impacts of different antithyroid antibodies.

Identifiants

pubmed: 34046196
doi: 10.2144/fsoa-2021-0029
pmc: PMC8147746
doi:

Types de publication

Clinical Trial Journal Article Review

Langues

eng

Pagination

FSO699

Informations de copyright

© 2021 Gregorio Scerrino.

Déclaration de conflit d'intérêts

Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties. No writing assistance was utilized in the production of this manuscript.

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Auteurs

Giuseppa Graceffa (G)

Department of Surgical Oncology & Oral Sciences, Unit of Oncological Surgery, University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.

Gregorio Scerrino (G)

Department of Surgical Oncology & Oral Sciences, Unit of General & Emergency Surgery, University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.

Gabriella Militello (G)

Department of Surgical Oncology & Oral Sciences, Unit of General & Emergency Surgery, University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.

Iole Laise (I)

Department of Surgical Oncology & Oral Sciences, Unit of Oncological Surgery, University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.

Brenda Randisi (B)

Department of Surgical Oncology & Oral Sciences, Unit of General & Emergency Surgery, University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.

Giuseppina Melfa (G)

Department of Surgical Oncology & Oral Sciences, Unit of General & Emergency Surgery, University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.

Giuseppina Orlando (G)

Department of Surgical Oncology & Oral Sciences, Unit of General & Emergency Surgery, University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.

Sergio Mazzola (S)

Unit of Clinical Epidemiology & Tumor Registry, Department of Laboratory Diagnostics, Policlinico P. Giaccone University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.

Calogero Cipolla (C)

Department of Surgical Oncology & Oral Sciences, Unit of Oncological Surgery, University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.

Gianfranco Cocorullo (G)

Department of Surgical Oncology & Oral Sciences, Unit of Oncological Surgery, University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.

Classifications MeSH