Iridium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of 1,3-Disubstituted Isoquinolines.

asymmetric catalysis heterocycles hydrogenation isoquinolines tetrahydroisoquinolines

Journal

ACS catalysis
ISSN: 2155-5435
Titre abrégé: ACS Catal
Pays: United States
ID NLM: 101562209

Informations de publication

Date de publication:
06 Mar 2020
Historique:
entrez: 28 5 2021
pubmed: 6 3 2020
medline: 6 3 2020
Statut: ppublish

Résumé

The development of a general method utilizing a hydroxymethyl directing group for asymmetric hydrogenation of 1,3-disubstituted isoquinolines to provide chiral 1,2,3,4-tetrahydroisoquinolines is reported. The reaction, which utilizes [Ir(cod)Cl]

Identifiants

pubmed: 34046244
doi: 10.1021/acscatal.0c00211
pmc: PMC8152574
mid: NIHMS1561287
doi:

Types de publication

Journal Article

Langues

eng

Pagination

3241-3248

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM127972
Pays : United States

Références

Science. 2019 Jan 18;363(6424):270-275
pubmed: 30573544
Chemistry. 2015 Jan 26;21(5):1915-27
pubmed: 25452095
J Med Chem. 2016 Oct 27;59(20):9489-9502
pubmed: 27709945
Org Lett. 2017 Sep 15;19(18):4988-4991
pubmed: 28879769
Chemistry. 2004 Sep 20;10(18):4546-55
pubmed: 15378634
J Med Chem. 2014 Dec 26;57(24):10257-74
pubmed: 25255204
Org Lett. 2012 Jun 15;14(12):3032-5
pubmed: 22646751
Org Lett. 2013 Oct 18;15(20):5162-5
pubmed: 24083625
J Med Chem. 2009 Nov 12;52(21):6752-6
pubmed: 19827778
Org Biomol Chem. 2009 Dec 7;7(23):4960-4
pubmed: 19907787
J Med Chem. 2014 Jul 24;57(14):5845-59
pubmed: 24471928
Chem Soc Rev. 2008 Dec;37(12):2676-90
pubmed: 19020681
Chem Rev. 2002 May;102(5):1669-730
pubmed: 11996547
Chem Rev. 2016 Aug 10;116(15):8655-92
pubmed: 27483171
ACS Comb Sci. 2016 Sep 12;18(9):569-74
pubmed: 27518324
Org Lett. 2016 Nov 4;18(21):5632-5635
pubmed: 27739295
Chem Sci. 2016 May 1;7(5):3047-3051
pubmed: 29997795
Chem Commun (Camb). 2015 Sep 4;51(68):13327-9
pubmed: 26208288
Chemistry. 2004 Jan 5;10(1):267-78
pubmed: 14695572
J Med Chem. 2011 May 26;54(10):3451-79
pubmed: 21504168
Acc Chem Res. 2007 Dec;40(12):1357-66
pubmed: 17896823
Angew Chem Int Ed Engl. 2006 Mar 27;45(14):2260-3
pubmed: 16518783
Org Biomol Chem. 2016 Jan 21;14(3):1065-90
pubmed: 26632484
Chem Commun (Camb). 2013 Oct 4;49(76):8537-9
pubmed: 23945790
Angew Chem Int Ed Engl. 2013 Sep 9;52(37):9616-8
pubmed: 23881748
J Org Chem. 2016 Feb 19;81(4):1401-9
pubmed: 26795702
Angew Chem Int Ed Engl. 2012 Aug 13;51(33):8286-9
pubmed: 22786808
J Org Chem. 2014 Aug 1;79(15):7041-50
pubmed: 24992575
Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11605-8
pubmed: 22753504
Angew Chem Int Ed Engl. 2013 Feb 11;52(7):2046-50
pubmed: 23303624
Chem Rev. 2012 Apr 11;112(4):2557-90
pubmed: 22098109
Angew Chem Int Ed Engl. 2013 Mar 25;52(13):3685-9
pubmed: 23424169
Chem Rev. 2016 Oct 12;116(19):12369-12465
pubmed: 27680197
Carbohydr Res. 2010 Apr 19;345(6):780-6
pubmed: 20206338

Auteurs

Alexia N Kim (AN)

Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.

Aurapat Ngamnithiporn (A)

Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.

Eric R Welin (ER)

Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.

Martin T Daiger (MT)

Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.

Christian U Grünanger (CU)

Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.

Michael D Bartberger (MD)

1200 Pharma LLC, 844 East Green Street, Suite 204, Pasadena, California, 91101, United States.

Scott C Virgil (SC)

Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.

Brian M Stoltz (BM)

Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.

Classifications MeSH