Assessment of the rules related to gaining activity against Gram-negative bacteria.
Journal
RSC medicinal chemistry
ISSN: 2632-8682
Titre abrégé: RSC Med Chem
Pays: England
ID NLM: 101759460
Informations de publication
Date de publication:
28 Apr 2021
28 Apr 2021
Historique:
received:
04
12
2020
accepted:
30
01
2021
entrez:
28
5
2021
pubmed:
29
5
2021
medline:
29
5
2021
Statut:
epublish
Résumé
In the search for new antibacterial compounds, we repositioned an antimalarial compound class by derivatising it based on the so-called "eNTRy" rules for enhanced accumulation into Gram-negative bacteria. We designed, synthesised and evaluated a small library of amino acid modified compounds together with the respective Boc-protected analogues, leading to no substantial improvement in antibacterial activity against
Identifiants
pubmed: 34046630
doi: 10.1039/d0md00409j
pii: d0md00409j
pmc: PMC8128065
doi:
Types de publication
Journal Article
Langues
eng
Pagination
593-601Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
There are no conflicts to declare.
Références
Nature. 2018 Sep;561(7722):189-194
pubmed: 30209367
Adv Drug Deliv Rev. 2021 May;172:339-360
pubmed: 33705882
Org Biomol Chem. 2008 Aug 7;6(15):2719-30
pubmed: 18633530
J Med Chem. 2019 Aug 22;62(16):7489-7505
pubmed: 31306011
J Med Chem. 2014 Dec 11;57(23):9740-63
pubmed: 25210872
Nat Commun. 2019 Jun 14;10(1):2635
pubmed: 31201302
Nature. 2017 May 18;545(7654):299-304
pubmed: 28489819
Int J Cancer. 2007 Jul 1;121(1):206-10
pubmed: 17351902
J Am Chem Soc. 2020 Jun 17;142(24):10856-10862
pubmed: 32432858
J Med Chem. 1968 May;11(3):430-41
pubmed: 5656475
J Med Chem. 2020 Mar 26;63(6):2789-2801
pubmed: 31765155
Nature. 1995 Mar 16;374(6519):269-71
pubmed: 7885447
Annu Rev Microbiol. 1998;52:81-104
pubmed: 9891794
ACS Infect Dis. 2018 Oct 12;4(10):1487-1498
pubmed: 29962203
Science. 1976 Aug 20;193(4254):673-5
pubmed: 781840
Microbiology (Reading). 2012 Jun;158(Pt 6):1389-1401
pubmed: 22466083
ACS Infect Dis. 2019 Oct 11;5(10):1688-1692
pubmed: 31478369
Lancet Infect Dis. 2019 Feb;19(2):e40-e50
pubmed: 30337260
Nat Rev Microbiol. 2020 Mar;18(3):164-176
pubmed: 31792365
Bioorg Med Chem Lett. 2014 Jan 15;24(2):560-4
pubmed: 24373723
Ann N Y Acad Sci. 2019 Jan;1435(1):18-38
pubmed: 29446459
J Med Chem. 2020 Sep 10;63(17):9623-9649
pubmed: 32787097
J Med Chem. 2015 Feb 12;58(3):1205-14
pubmed: 25559643
Chem Rev. 2017 Apr 26;117(8):5675-5703
pubmed: 27995802
Bioessays. 2006 Jan;28(1):9-22
pubmed: 16369945
Acta Trop. 1993 Dec;55(4):257-61
pubmed: 8147282
Mol Microbiol. 2015 Jun;96(6):1272-82
pubmed: 25807888
Anal Chem. 2019 Feb 5;91(3):1863-1872
pubmed: 30485749
Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1062-7
pubmed: 10655484
FEMS Microbiol Lett. 1998 Jun 1;163(1):65-72
pubmed: 9631547
ACS Infect Dis. 2018 Aug 10;4(8):1223-1234
pubmed: 29756762
J Bacteriol. 1972 Oct;112(1):315-26
pubmed: 4562400
J Bacteriol. 1983 Sep;155(3):1463-6
pubmed: 6350273
J Med Chem. 2008 May 22;51(10):2871-8
pubmed: 18260614