Periodontitis and pulmonary function: a Mendelian randomization study.
Lung function
Mendelian randomization
Periodontitis
Journal
Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
12
04
2021
accepted:
19
05
2021
pubmed:
29
5
2021
medline:
10
8
2021
entrez:
28
5
2021
Statut:
ppublish
Résumé
Observational research suggests that periodontitis affects pulmonary function; however, observational studies are subject to confounding and reverse causation, making causal inference and the direction of these associations difficult. We used Mendelian randomization (MR) to assess the potential causal association between genetic liability to periodontitis and pulmonary function. We used six single-nucleotide polymorphisms (SNPs) associated with periodontitis (P < 5 × 10 MR analysis suggested no effect of periodontitis on the ratio of forced expiratory volume in one second to lower forced vital capacity (standard deviation increment in outcome per doubling of the odds of the exposure (95% confidence interval) = - 0.004 (- 0.028; 0.020)). Replication analysis using genetic instruments from two different GWAS and sensitivity analyses to address potential pleiotropy led to no substantial changes in estimates. Collectively, these findings do not support a relationship between genetic liability for periodontitis and pulmonary function. Periodontitis does not seem to be a risk factor for worsening of pulmonary function.
Identifiants
pubmed: 34046741
doi: 10.1007/s00784-021-04000-9
pii: 10.1007/s00784-021-04000-9
pmc: PMC8342344
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5109-5112Informations de copyright
© 2021. The Author(s).
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