Cytokeratin 7 and 19 expression in oropharyngeal and oral squamous cell carcinoma.
Cytokeratin
Oropharyngeal neoplasms
Papillomavirus
Squamous cell carcinoma of head and neck
Tongue neoplasms
Journal
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
ISSN: 1434-4726
Titre abrégé: Eur Arch Otorhinolaryngol
Pays: Germany
ID NLM: 9002937
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
25
02
2021
accepted:
18
05
2021
pubmed:
29
5
2021
medline:
9
3
2022
entrez:
28
5
2021
Statut:
ppublish
Résumé
The precise etiopathogenesis of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC), and reasons for predilection for crypt epithelium, remain uncertain. The purpose of this study is to investigate the interaction between HPV and specific cytokeratins 7 (CK7) and 19 (CK19) in crypt epithelium. This is a retrospective cohort study of patients presenting between 1999 and 2015 at a tertiary referral center. CK7 and CK19 positivity and H Scores were determined by immunohistochemistry. Disease-specific and overall survival rates were analyzed. There were 253 patients presenting with OPSCC (134), squamous cell carcinoma (SCC) of unknown primary site (22), and oral tongue SCC (97). Primary tumor CK7 and CK19 positivity and H Scores were significantly higher in HPV-positive OPSCC than HPV-negative OPSCC and oral tongue SCC. Higher CK19 Scores, but not CK7 Scores, were also seen in regional metastases from HPV-positive OPSCC than other sites. No impact on disease-specific or overall survival was identified on multivariate analysis. The increased expression of CK7 and CK19 in HPV-positive OPSCC compared to HPV-negative disease supports the theory for a role for these cytokeratins in the etiopathogenesis of HPV-related OPSCC.
Identifiants
pubmed: 34046748
doi: 10.1007/s00405-021-06894-3
pii: 10.1007/s00405-021-06894-3
doi:
Substances chimiques
Keratin-7
0
Keratin-9
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1435-1443Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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