Slounase, a Batroxobin Containing Activated Factor X Effectively Enhances Hemostatic Clot Formation and Reducing Bleeding in Hypocoagulant Conditions in Mice.
batroxobin
bleeding
coagulation
fibrin
hemostasis
platelet
Journal
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
ISSN: 1938-2723
Titre abrégé: Clin Appl Thromb Hemost
Pays: United States
ID NLM: 9508125
Informations de publication
Date de publication:
Historique:
entrez:
28
5
2021
pubmed:
29
5
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Uncontrolled bleeding associated with trauma and surgery is the leading cause of preventable death. Batroxobin, a snake venom-derived thrombin-like serine protease, has been shown to clot fibrinogen by cleaving fibrinopeptide A in a manner distinctly different from thrombin, even in the presence of heparin. The biochemical properties of batroxobin and its effect on coagulation have been well characterized
Identifiants
pubmed: 34047195
doi: 10.1177/10760296211018510
pmc: PMC8165871
doi:
Substances chimiques
Hemostatics
0
Batroxobin
EC 3.4.21.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
10760296211018510Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM105671
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL114405
Pays : United States
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