First experience in clinical application of hyperspectral endoscopy for evaluation of colonic polyps.
colonoscopy
hyperspectral endoscope
hyperspectral imaging
machine learning
Journal
Journal of biophotonics
ISSN: 1864-0648
Titre abrégé: J Biophotonics
Pays: Germany
ID NLM: 101318567
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
revised:
07
05
2021
received:
03
03
2021
accepted:
23
05
2021
pubmed:
29
5
2021
medline:
21
10
2021
entrez:
28
5
2021
Statut:
ppublish
Résumé
Early detection and resection of adenomatous polyps prevents their progression to colorectal cancer (CRC), significantly improving patient outcomes. Polyps are typically identified and removed during white-light colonoscopy. Unfortunately, the rate of interval cancers that arise between CRC screening events remains high, linked to poor visualization of polyps during screening and incomplete polyp removal. Here, we sought to evaluate the potential of a hyperspectral endoscope (HySE) to enhance polyp discrimination for detection and resection. We designed, built and tested a new compact HySE in a proof-of-concept clinical study. We successfully collected spectra from three tissue types in seven patients undergoing routine colonoscopy screening. The acquired spectral data from normal tissue and polyps, both pre- and post- resection, were subjected to quantitative analysis using spectral angle mapping and machine learning, which discriminated the data by tissue type, meriting further investigation of HySE as a clinical tool.
Identifiants
pubmed: 34047490
doi: 10.1002/jbio.202100078
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202100078Subventions
Organisme : Cancer Research UK
ID : C14303/A17197
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C47594/A16267
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C47594/A21102
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C47594/A26851
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C55962/A24669
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C9545/A29580
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. Journal of Biophotonics published by Wiley-VCH GmbH.
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