The two facets of gp130 signalling in liver tumorigenesis.
Anti-tumour immunity
Cholangiocarcinoma (CCA)
Hepatocellular carcinoma (HCC)
IL-6
Inflammation
STAT3
Tumour micro-environment
gp130
Journal
Seminars in immunopathology
ISSN: 1863-2300
Titre abrégé: Semin Immunopathol
Pays: Germany
ID NLM: 101308769
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
31
12
2020
accepted:
28
04
2021
pubmed:
29
5
2021
medline:
27
10
2021
entrez:
28
5
2021
Statut:
ppublish
Résumé
The liver is a vital organ with multiple functions and a large regenerative capacity. Tumours of the liver are the second most frequently cause of cancer-related death and develop in chronically inflamed livers. IL-6-type cytokines are mediators of inflammation and almost all members signal via the receptor subunit gp130 and the downstream signalling molecule STAT3. We here summarize current knowledge on how gp130 signalling and STAT3 in tumour cells and cells of the tumour micro-environment drives hepatic tumorigenesis. We furthermore discuss very recent findings describing also anti-tumorigenic roles of gp130/STAT3 and important considerations for therapeutic interventions.
Identifiants
pubmed: 34047814
doi: 10.1007/s00281-021-00861-0
pii: 10.1007/s00281-021-00861-0
pmc: PMC8443519
doi:
Substances chimiques
Cytokine Receptor gp130
133483-10-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
609-624Informations de copyright
© 2021. The Author(s).
Références
Cancer Res. 2018 Sep 1;78(17):5011-5022
pubmed: 29967259
Radiology. 2018 Feb;286(2):524-536
pubmed: 28880787
Hepat Oncol. 2014 Oct;1(4):395-408
pubmed: 30190975
Nat Rev Gastroenterol Hepatol. 2021 Mar;18(3):151-166
pubmed: 33128017
Eur Radiol. 2017 Mar;27(3):1238-1247
pubmed: 27287478
Nat Commun. 2015 Mar 03;6:6285
pubmed: 25734337
Gut. 2002 Jul;51(1):120-7
pubmed: 12077104
Nature. 2015 Mar 5;519(7541):57-62
pubmed: 25731159
N Engl J Med. 2008 Jul 24;359(4):378-90
pubmed: 18650514
PLoS One. 2015 May 06;10(5):e0126296
pubmed: 25946003
Gut. 2018 Sep;67(9):1704-1715
pubmed: 28754776
J Hepatol. 2020 Nov;73(5):1030-1036
pubmed: 32512015
Nature. 2019 Mar;567(7747):249-252
pubmed: 30842658
Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2207-12
pubmed: 20133864
Hepatology. 2003 Aug;38(2):326-34
pubmed: 12883476
Cancers (Basel). 2020 Mar 10;12(3):
pubmed: 32164265
Toxicol Pathol. 2001 Mar-Apr;29(2):242-9
pubmed: 11421492
Cell. 2019 Oct 31;179(4):813-827
pubmed: 31675495
Cell Metab. 2015 Mar 3;21(3):403-16
pubmed: 25738456
Nat Commun. 2015 Jul 22;6:7736
pubmed: 26198641
Eur J Immunol. 1993 Feb;23(2):473-80
pubmed: 8436181
Hepatology. 2017 May;65(5):1600-1611
pubmed: 28027584
Biochim Biophys Acta. 2010 Nov;1802(11):1054-61
pubmed: 20691261
Cell Physiol Biochem. 2018;48(1):158-172
pubmed: 30001540
Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):E2361-70
pubmed: 22891351
Nat Commun. 2021 Jan 4;12(1):66
pubmed: 33397952
Gastroenterology. 2000 Dec;119(6):1663-71
pubmed: 11113088
Cell. 2020 Mar 5;180(5):833-846.e16
pubmed: 32142677
Cytokine Growth Factor Rev. 2015 Oct;26(5):475-87
pubmed: 26189695
J Hepatol. 2020 Oct;73(4):906-917
pubmed: 32407813
Cell Mol Immunol. 2004 Jun;1(3):205-11
pubmed: 16219169
Hepatology. 2011 Sep 2;54(3):846-56
pubmed: 21725996
Mol Cancer Res. 2007 Nov;5(11):1159-70
pubmed: 18025261
Life Sci. 2020 Feb 1;242:117241
pubmed: 31891719
J Hepatol. 2021 Feb;74(2):407-418
pubmed: 32987028
Gastroenterology. 2012 Sep;143(3):765-776.e3
pubmed: 22687286
Proc Natl Acad Sci U S A. 1987 Oct;84(20):7251-5
pubmed: 2444978
Radiology. 2016 Aug;280(2):413-24
pubmed: 27429143
Nature. 2011 Nov 09;479(7374):547-51
pubmed: 22080947
Cell Cycle. 2018;17(21-22):2423-2435
pubmed: 30395772
J Hepatol. 2016 Jun;64(6):1403-15
pubmed: 26867490
Cells. 2020 Apr 03;9(4):
pubmed: 32260126
Biochem Biophys Res Commun. 2017 Apr 29;486(2):239-244
pubmed: 28254435
J Hepatol. 2020 Nov;73(5):1118-1130
pubmed: 32505533
J Clin Invest. 2019 Jul 15;129(8):3324-3338
pubmed: 31305264
Hepatology. 2011 Aug;54(2):597-608
pubmed: 21574169
Hepatology. 2014 Jul;60(1):290-300
pubmed: 24668739
Int Immunopharmacol. 2017 Oct;51:99-106
pubmed: 28822324
Lancet. 2018 Mar 31;391(10127):1301-1314
pubmed: 29307467
Nat Rev Immunol. 2018 Dec;18(12):773-789
pubmed: 30254251
Cell Death Dis. 2015 Mar 05;6:e1667
pubmed: 25741592
JCI Insight. 2019 Aug 8;4(15):
pubmed: 31391340
Hepatology. 2008 Apr;47(4):1298-308
pubmed: 18307269
PLoS One. 2015 Jul 08;10(7):e0128910
pubmed: 26154425
Hepatology. 2019 Dec;70(6):2075-2091
pubmed: 31100194
Antioxidants (Basel). 2020 Mar 19;9(3):
pubmed: 32204510
Hepatology. 2003 Jul;38(1):218-29
pubmed: 12830005
Nat Immunol. 2007 Sep;8(9):967-74
pubmed: 17581537
Clin Exp Pharmacol Physiol. 2017 Feb;44(2):213-221
pubmed: 27797409
Hepatology. 2007 Sep;46(3):740-8
pubmed: 17663417
Nature. 1994 Mar 24;368(6469):339-42
pubmed: 8127368
J Hepatol. 2009 May;50(5):980-9
pubmed: 19329213
PLoS Biol. 2020 Jan 16;18(1):e3000599
pubmed: 31945054
Gastroenterology. 2003 Aug;125(2):532-43
pubmed: 12891556
Int J Hyperthermia. 2018 Nov;34(7):934-942
pubmed: 29631466
Cancer Cell. 2014 May 12;25(5):666-81
pubmed: 24768205
J Exp Med. 2017 Sep 4;214(9):2547-2562
pubmed: 28747427
J Biol Chem. 2003 Oct 3;278(40):38829-39
pubmed: 12832423
Cell Rep. 2013 Aug 29;4(4):669-80
pubmed: 23954788
Nat Rev Gastroenterol Hepatol. 2017 Jul;14(7):397-411
pubmed: 28487545
Biochim Biophys Acta Mol Cell Res. 2017 Mar;1864(3):516-526
pubmed: 27939431
J Biol Chem. 2012 May 25;287(22):18182-9
pubmed: 22496368
Lancet. 2018 Mar 24;391(10126):1163-1173
pubmed: 29433850
J Gene Med. 2010 May;12(5):423-34
pubmed: 20440753
Am J Pathol. 2000 May;156(5):1627-39
pubmed: 10793074
Nature. 2020 Nov;587(7835):555-566
pubmed: 33239795
J Clin Invest. 2015 Nov 2;125(11):4239-54
pubmed: 26457732
Int J Hyperthermia. 2020;37(1):119-129
pubmed: 31969029
Gut. 2020 Jun;69(6):1064-1075
pubmed: 31586932
Gastroenterology. 2017 Jul;153(1):178-190.e10
pubmed: 28400195
Hepatology. 2017 Jan;65(1):89-103
pubmed: 27770462
Hepatology. 2021 Jul;74(1):116-132
pubmed: 33236445
Cancer Cell. 2009 Nov 6;16(5):425-38
pubmed: 19878874
Am J Clin Pathol. 2008 Feb;129(2):245-51
pubmed: 18208805
Gastroenterology. 1996 Jun;110(6):1854-62
pubmed: 8964411
Cell Stem Cell. 2011 Jul 8;9(1):50-63
pubmed: 21726833
Mol Biol Cell. 2006 Jul;17(7):2986-95
pubmed: 16624864
J Hepatol. 2020 Jan;72(1):167-182
pubmed: 31449859
Cancers (Basel). 2020 Mar 29;12(4):
pubmed: 32235370
Hepatology. 2021 May;73(5):1717-1735
pubmed: 33682185
Clin Cancer Res. 2019 Jun 15;25(12):3643-3657
pubmed: 30824583
Hepatol Commun. 2019 May 10;3(7):867-882
pubmed: 31334440
Oncotarget. 2017 Jan 17;8(3):4690-4702
pubmed: 27902467
J Clin Invest. 2014 Oct;124(10):4657-67
pubmed: 25244097
Oncotarget. 2016 Oct 4;7(40):65797-65807
pubmed: 27589562
BMC Cancer. 2015 Nov 02;15:830
pubmed: 26525581
Radiology. 2015 Aug;276(2):426-32
pubmed: 26203709
N Engl J Med. 2020 May 14;382(20):1894-1905
pubmed: 32402160
Am J Pathol. 2013 Mar;182(3):742-54
pubmed: 23306157
J Autoimmun. 2013 Oct;46:25-34
pubmed: 23948302
Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):308-321
pubmed: 30419338
Trends Pharmacol Sci. 1988 Aug;9(8):271-2
pubmed: 2471339
Sci Signal. 2012 Jan 17;5(207):ra5
pubmed: 22253262
Exp Cell Res. 2005 May 15;306(1):252-63
pubmed: 15878349
Hepatology. 2020 Mar;71(3):893-906
pubmed: 31298745
Nat Rev Cancer. 2020 Mar;20(3):174-186
pubmed: 31980749
Nature. 2009 Jan 8;457(7226):200-4
pubmed: 19020503
Radiology. 2016 Apr;279(1):103-17
pubmed: 26418615
Eur J Cancer. 2012 Jan;48(1):85-93
pubmed: 22129890
Biochem Cell Biol. 2017 Apr;95(2):263-272
pubmed: 28177770
Cell. 2010 Jan 22;140(2):197-208
pubmed: 20141834
Science. 1996 Nov 22;274(5291):1379-83
pubmed: 8910279
Cancer Res. 2010 Jun 1;70(11):4687-97
pubmed: 20484035
Gastroenterology. 2019 May;156(6):1890-1904.e16
pubmed: 30711627
J Clin Invest. 2005 Apr;115(4):860-9
pubmed: 15761498
Cancer Immunol Res. 2019 Dec;7(12):1944-1957
pubmed: 31554639
Nat Cell Biol. 2014 Oct;16(10):972-7
pubmed: 25173978
BMC Gastroenterol. 2015 Apr 25;15:50
pubmed: 25908103
Cell. 2013 Oct 10;155(2):384-96
pubmed: 24120137
Biochem Biophys Res Commun. 2011 Mar 25;406(4):614-20
pubmed: 21356197
Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):1906-10
pubmed: 15684062
Oncotarget. 2015 Mar 30;6(9):6989-99
pubmed: 25749520
Hepatology. 2014 Jun;59(6):2263-75
pubmed: 24390753
Gastroenterology. 2010 Mar;138(3):1003-11.e1-5
pubmed: 19962983
Nat Cell Biol. 2014 Nov;16(11):1057-1068
pubmed: 25283994
Cell Rep. 2017 Oct 17;21(3):773-783
pubmed: 29045843
Nat Immunol. 2015 Dec;16(12):1235-44
pubmed: 26502405
Radiology. 2020 Feb;294(2):464-472
pubmed: 31845846
BioDrugs. 1997 Dec;8(6):418-29
pubmed: 18031104
J Exp Med. 2019 Sep 2;216(9):1986-1998
pubmed: 31235509
EBioMedicine. 2019 Aug;46:119-132
pubmed: 31375423
Hepatology. 2011 Sep 2;54(3):900-9
pubmed: 21674558
J Hepatol. 2011 May;54(5):922-9
pubmed: 21145830
Gut. 2018 May;67(5):931-944
pubmed: 28939663
J Exp Med. 2011 Jul 4;208(7):1359-66
pubmed: 21690253
J Exp Med. 2010 Jul 5;207(7):1453-64
pubmed: 20530204
Am J Pathol. 1998 Aug;153(2):639-48
pubmed: 9708822
Genes Dev. 2008 Feb 15;22(4):449-62
pubmed: 18258752
J Immunol. 1998 Oct 1;161(7):3575-81
pubmed: 9759879
Radiology. 2015 Aug;276(2):416-25
pubmed: 25822472
Immunol Today. 1994 Feb;15(2):74-80
pubmed: 7512342
Cancer Res. 2015 Jul 1;75(13):2663-73
pubmed: 25977329
Am J Pathol. 2007 Sep;171(3):872-81
pubmed: 17640959
Surg Clin North Am. 2004 Apr;84(2):339-54
pubmed: 15062649
Hepatology. 1998 Nov;28(5):1260-8
pubmed: 9794910
Cell. 2020 Jan 9;180(1):79-91.e16
pubmed: 31866067
Radiology. 2011 Feb;258(2):351-69
pubmed: 21273519
World J Gastroenterol. 2014 Dec 21;20(47):17851-62
pubmed: 25548483
J Immunol. 1997 Aug 1;159(3):1474-81
pubmed: 9233646
J Hepatol. 2021 Feb;74(2):458-465
pubmed: 33303216
Genes Dev. 2018 Sep 1;32(17-18):1175-1187
pubmed: 30135074
PLoS One. 2013 Jun 25;8(6):e66268
pubmed: 23825534
Nature. 2019 Oct;574(7777):268-272
pubmed: 31578521
Cancer Cell. 2012 Apr 17;21(4):504-16
pubmed: 22516259
Hepatology. 2004 Mar;39(3):635-44
pubmed: 14999682
Immunol Today. 1990 Oct;11(10):350-4
pubmed: 2171545
J Hepatol. 2020 Feb;72(2):230-238
pubmed: 31954488
Nat Med. 2002 Jan;8(1):75-9
pubmed: 11786910
Gastroenterology. 2019 Sep;157(3):777-792.e14
pubmed: 31078624
Cell Death Dis. 2018 Mar 19;9(4):422
pubmed: 29556041
Gastroenterology. 2014 Dec;147(6):1393-404
pubmed: 25181692
Oncogene. 2002 Jan 3;21(1):32-43
pubmed: 11791174
Nat Rev Rheumatol. 2017 Jul;13(7):399-409
pubmed: 28615731
Hepatology. 2018 Jan;67(1):296-312
pubmed: 28779552
Oncogene. 2013 Apr 18;32(16):1995-2004
pubmed: 22777359
Nature. 1986 Nov 6-12;324(6092):73-6
pubmed: 3491322
Cells. 2019 Dec 20;9(1):
pubmed: 31861914
Hepatology. 2006 Nov;44(5):1206-17
pubmed: 17058237
Cell Death Discov. 2020 Jun 2;6:42
pubmed: 32528731
Cold Spring Harb Perspect Biol. 2018 Feb 1;10(2):
pubmed: 28620096
Cell. 2010 Mar 19;140(6):883-99
pubmed: 20303878
Gastroenterology. 2007 Jan;132(1):294-300
pubmed: 17241879
J Hepatol. 2021 Apr;74(4):919-930
pubmed: 33197512
Science. 2007 Jul 6;317(5834):121-4
pubmed: 17615358
Nat Rev Gastroenterol Hepatol. 2020 Mar;17(3):135-136
pubmed: 31965074
Cytokine Growth Factor Rev. 2015 Oct;26(5):545-58
pubmed: 26198770
Hepatology. 2000 Jul;32(1):26-35
pubmed: 10869285
J Leukoc Biol. 2018 Nov;104(5):969-985
pubmed: 30040142
Hepatology. 2009 Jul;50(1):253-60
pubmed: 19441100
Clin Exp Immunol. 2009 Jun;156(3):518-27
pubmed: 19438606
Biochem J. 1994 Jun 1;300 ( Pt 2):281-90
pubmed: 8002928
Oncotarget. 2016 Aug 23;7(34):55639-55648
pubmed: 27489351