Clinical and histological features in pediatric and adolescent/young adult patients with renal disease: a cross-sectional analysis of the Japan Renal Biopsy Registry (J-RBR).
Adolescent
Adult
Age Distribution
Biopsy
Child
Child, Preschool
Cross-Sectional Studies
Female
Glomerular Filtration Rate
Glomerulonephritis, IGA
/ epidemiology
Glomerulonephritis, Membranoproliferative
/ epidemiology
Humans
Infant
Japan
/ epidemiology
Kidney Glomerulus
/ pathology
Male
Nephrotic Syndrome
/ epidemiology
Proteinuria
/ epidemiology
Registries
Young Adult
Adolescent
Chronic kidney disease
Cross-sectional analysis
Nephrotic syndrome
Young adult
Journal
Clinical and experimental nephrology
ISSN: 1437-7799
Titre abrégé: Clin Exp Nephrol
Pays: Japan
ID NLM: 9709923
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
28
12
2020
accepted:
12
05
2021
pubmed:
29
5
2021
medline:
12
1
2022
entrez:
28
5
2021
Statut:
ppublish
Résumé
Only a few studies have investigated epidemiological and clinicopathological information regarding pediatric and adolescent and young adult (AYA) patients with renal disease. The purpose of this study was to clarify the differences and relationship of clinicopathological findings between pediatric and AYA patients using the Japan Renal Biopsy Registry (J-RBR). This cross-sectional study analyzed data from patients registered in the J-RBR between 2007 and 2017. Clinicopathological findings at diagnosis were analyzed for 3,463 pediatric (age < 15 years) and 6,532 AYA (age 15-30 years) patients. Although chronic nephritic syndrome was the most common clinical diagnosis at age > 5 years, nephrotic syndrome was the most frequent diagnosis at age < 4 years. The most common pathological diagnosis as classified by pathogenesis in pediatric patients was primary glomerular disease (except IgA nephropathy), whereas IgA nephropathy was increased in AYA patients. Mesangial proliferative glomerulonephritis was the most common pathological diagnosis as classified by histopathology in both pediatric and AYA patients. Minor glomerular abnormalities were the most frequent histopathologic diagnoses of nephrotic syndrome in childhood, but their frequency decreased with age. To the best of our knowledge, this is the first report of clinicopathological features of pediatric and AYA patients in a large nationwide registry of renal biopsy. There were differences of clinical, pathological and histopathologic findings between pediatric and AYA patients.
Sections du résumé
BACKGROUND
BACKGROUND
Only a few studies have investigated epidemiological and clinicopathological information regarding pediatric and adolescent and young adult (AYA) patients with renal disease. The purpose of this study was to clarify the differences and relationship of clinicopathological findings between pediatric and AYA patients using the Japan Renal Biopsy Registry (J-RBR).
METHODS
METHODS
This cross-sectional study analyzed data from patients registered in the J-RBR between 2007 and 2017. Clinicopathological findings at diagnosis were analyzed for 3,463 pediatric (age < 15 years) and 6,532 AYA (age 15-30 years) patients.
RESULTS
RESULTS
Although chronic nephritic syndrome was the most common clinical diagnosis at age > 5 years, nephrotic syndrome was the most frequent diagnosis at age < 4 years. The most common pathological diagnosis as classified by pathogenesis in pediatric patients was primary glomerular disease (except IgA nephropathy), whereas IgA nephropathy was increased in AYA patients. Mesangial proliferative glomerulonephritis was the most common pathological diagnosis as classified by histopathology in both pediatric and AYA patients. Minor glomerular abnormalities were the most frequent histopathologic diagnoses of nephrotic syndrome in childhood, but their frequency decreased with age.
CONCLUSION
CONCLUSIONS
To the best of our knowledge, this is the first report of clinicopathological features of pediatric and AYA patients in a large nationwide registry of renal biopsy. There were differences of clinical, pathological and histopathologic findings between pediatric and AYA patients.
Identifiants
pubmed: 34047871
doi: 10.1007/s10157-021-02077-w
pii: 10.1007/s10157-021-02077-w
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1018-1026Investigateurs
Naoyuki Hasebe
(N)
Naoki Nakagawa
(N)
Sekiya Shibazaki
(S)
Tomotsune Miyamoto
(T)
Masanori Ito
(M)
Saori Nishio
(S)
Daigo Nakazawa
(D)
Takayuki Okamoto
(T)
Yasuyuki Sato
(Y)
Akira Suzuki
(A)
Norihito Moniwa
(N)
Marenao Tanaka
(M)
Yuichiro Fukasawa
(Y)
Hideki Takizawa
(H)
Jun Soma
(J)
Izaya Nakaya
(I)
Junichiro James Kazama
(JJ)
Kennichi Tanaka
(K)
Mizuko Tanaka
(M)
Toshinobu Sato
(T)
Satoru Sanada
(S)
Hideaki Hashimoto
(H)
Mariko Miyazaki
(M)
Tasuku Nagasawa
(T)
Koji Okamoto
(K)
Tsuneo Konta
(T)
Kazunobu Ichikawa
(K)
Daisuke Ogino
(D)
Hiroshi Kitamura
(H)
Toshiyuki Imasawa
(T)
Chieko Matsumura
(C)
Naotake Akutsu
(N)
Koichi Kamura
(K)
Tetsuro Takeda
(T)
Toshihiko Ishimitsu
(T)
Keiju Hiromura
(K)
Yoriaki Kaneko
(Y)
Hidekazu Ikeuchi
(H)
Toru Sakairi
(T)
Daisuke Nagata
(D)
Osamu Saito
(O)
Tetsu Akimoto
(T)
Akito Maeshima
(A)
Takashi Yokoo
(T)
Nobuo Tsuboi
(N)
Kentaro Koike
(K)
Yudo Tanno
(Y)
Shinya Yokote
(S)
Yoichi Miyazaki
(Y)
Hiroyuki Ueda
(H)
Masahiro Okabe
(M)
Mai Tanaka
(M)
Masato Ikeda
(M)
Akihiro Shimizu
(A)
Yusuke Suzuki
(Y)
Tomohito Goda
(T)
Masao Kihara
(M)
Miyuki Takagi
(M)
Masahiro Ishikawa
(M)
Shinya Kaname
(S)
Miho Karube
(M)
Kazuhito Fukuoka
(K)
Takahisa Kawakami
(T)
Itaru Ebihara
(I)
Chihiro Sato
(C)
Yukinao Sakai
(Y)
Akio Hirama
(A)
Akiko Mii
(A)
Yoshinobu Fuke
(Y)
Masanori Abe
(M)
Hirokazu Okada
(H)
Tsutomu Inoue
(T)
Takatsugu Iwashita
(T)
Yuta Kogure
(Y)
Koichi Kanozawa
(K)
Hajime Hasegawa
(H)
Masamitsu Ubukata
(M)
Takanori Shibata
(T)
Yoshihiko Inoue
(Y)
Tomo Suzuki
(T)
Daisuke Ichikawa
(D)
Sayuri Shirai
(S)
Yugo Shibagaki
(Y)
Takehiko Wada
(T)
Masafumi Fukagawa
(M)
Yoshihide Fujigaki
(Y)
Shigeo Horie
(S)
Satoru Muto
(S)
Masaki Kobayashi
(M)
Kouichi Hirayama
(K)
Homare Shimohata
(H)
Riku Hamada
(R)
Hiroshi Hataya
(H)
Motoshi Hattori
(M)
Kenichiro Miura
(K)
Kiyonobu Ishizuka
(K)
Naoto Kaneko
(N)
Kosaku Nitta
(K)
Keiko Uchida
(K)
Takahito Moriyama
(T)
Yoshifumi Ubara
(Y)
Tatsuya Suwabe
(T)
Junichi Hoshino
(J)
Noriko Hayami
(N)
Masaomi Nangaku
(M)
Tetsuhiro Tanaka
(T)
Yoshifumi Hamasaki
(Y)
Kenjiro Honda
(K)
Yutaka Harita
(Y)
Shoichiro Kanda
(S)
Yuko Kajiho
(Y)
Kunihiro Yamagata
(K)
Joichi Usui
(J)
Tetsuya Kawamura
(T)
Kouichi Tamura
(K)
Hiromichi Wakui
(H)
Tomohiko Kanaoka
(T)
Ryu Kobayashi
(R)
Nobuhito Hirawa
(N)
Sanae Saka
(S)
Akira Fujiwara
(A)
Ichiei Narita
(I)
Shin Goto
(S)
Yumi Itoh
(Y)
Naofumi Imai
(N)
Yuji Kamijo
(Y)
Koji Hashimoto
(K)
Akinori Yamaguchi
(A)
Sonoda Kosuke
(S)
Kazuya Takahashi
(K)
Fumihiko Furuya
(F)
Kiyoki Kitagawa
(K)
Hitoshi Yokoyama
(H)
Keiji Fujimoto
(K)
Norifumi Hayashi
(N)
Daisuke Koya
(D)
Munehiro Kitada
(M)
Yuka Kuroshima
(Y)
Takashi Wada
(T)
Kengo Furuichi
(K)
Miho Shimizu
(M)
Norihiko Sakai
(N)
Yasuhiro Katou
(Y)
Yuta Yamamura
(Y)
Yoshitaka Koshino
(Y)
Chikako Takaeda
(C)
Haruyoshi Yoshida
(H)
Takayasu Horiguchi
(T)
Yasuyuki Shinozaki
(Y)
Masahiko Kawabata
(M)
Satoshi Ota
(S)
Yoh-Ichi Ishida
(YI)
Masayuki Iwano
(M)
Naoki Takahashi
(N)
Kenji Kasuno
(K)
Daisuke Mikami
(D)
Hidenori Yamazaki
(H)
Naoya Fujita
(N)
Satoshi Hibino
(S)
Kazuki Tanaka
(K)
Yasuhiko Ito
(Y)
Takuhito Nagai
(T)
Takayuki Katsuno
(T)
Hironobu Nobata
(H)
Shogo Kimura
(S)
Yuka Soga
(Y)
Masanori Sakakima
(M)
Yukio Yuzawa
(Y)
Naotake Tsuboi
(N)
Hiroki Hayashi
(H)
Kazuo Takahashi
(K)
Hideo Yasuda
(H)
Naro Ohashi
(N)
Taichi Sato
(T)
Asami Takeda
(A)
Yasuhiro Otsuka
(Y)
Minamo Ono
(M)
Tatsuya Tomonari
(T)
Michio Fukuda
(M)
Masashi Mizuno
(M)
Taisei Suzuki
(T)
Satoru Kominato
(S)
Hirotake Kasuga
(H)
Shoichi Maruyama
(S)
Yoshinari Yasuda
(Y)
Tomoki Kosugi
(T)
Takuji Ishimoto
(T)
Noriko Mori
(N)
Satoshi Tanaka
(S)
Tomohiro Murata
(T)
Mika Fujimoto
(M)
Kan Katayama
(K)
Yokkaichi Hazu
(Y)
Yasuhide Mizutani
(Y)
Hitoshi Kodera
(H)
Masato Miyake
(M)
Kazumasa Oka
(K)
Nobuyuki Kajiwara
(N)
Tatsuo Tsukamoto
(T)
Tomomi Endo
(T)
Eri Muso
(E)
Shinichi Nishi
(S)
Shunsuke Goto
(S)
Kazumoto Iijima
(K)
Kandai Nozu
(K)
Tomohiko Yamamura
(T)
Yoko Adachi
(Y)
Takaaki Nishihara
(T)
Michitsugu Kamezaki
(M)
Koichi Seta
(K)
Kensei Yahata
(K)
Keiichi Tamagaki
(K)
Tetsuro Kusaba
(T)
Yayoi Shiotsu
(Y)
Motoko Yanagita
(M)
Hideki Yokoi
(H)
Kaoru Sakai
(K)
Akira Ishii
(A)
Kazuhiko Tsuruya
(K)
Kenichi Samejima
(K)
Fumiki Yoshihara
(F)
Katsuhito Mori
(K)
Akihiro Tsuda
(A)
Shinya Nakatani
(S)
Yoshio Konishi
(Y)
Takashi Morikawa
(T)
Chizuko Kitabayashi
(C)
Rika Fujimaru
(R)
Terumasa Hayashi
(T)
Tatsuya Shoji
(T)
Katsusuke Yamamoto
(K)
Akira Ashida
(A)
Akira Sugawara
(A)
Masao Koshikawa
(M)
Yoshihisa Ogawa
(Y)
Tomoko Kawanishi
(T)
Atsushi Yamauchi
(A)
Katsuyuki Nagatoya
(K)
Daisuke Mori
(D)
Ryota Haga
(R)
Yoshitaka Isaka
(Y)
Ryohei Yamamoto
(R)
Tomoko Namba
(T)
Toshiki Nishio
(T)
Shinichi Araki
(S)
Shigeichi Shoji
(S)
Kenjiro Yamakawa
(K)
Senji Okuno
(S)
Megumu Fukunaga
(M)
Yuko Shima
(Y)
Taketsugu Hama
(T)
Takashi Shigematsu
(T)
Masaki Ohya
(M)
Naoki Kashihara
(N)
Kenichiro Asano
(K)
Motoko Kanzaki
(M)
Kosuke Fukuoka
(K)
Takao Masaki
(T)
Shigehiro Doi
(S)
Ayumu Nakashima
(A)
Toshiki Doi
(T)
Kan Yamazaki
(K)
Nobuyoshi Sugiyama
(N)
Yuichiro Inaba
(Y)
Kouji Ozeki
(K)
Makoto Hiramatsu
(M)
Keisuke Maruyama
(K)
Noriya Momoki
(N)
Hiroshi Morinaga
(H)
Ayu Akiyama
(A)
Natsumi Uchiyama
(N)
Mariko Nishiwaki
(M)
Tsuyoshi Imai
(T)
Takafumi Ito
(T)
Masahiro Egawa
(M)
Shohei Fukunaga
(S)
Shinichi Okada
(S)
Koichi Kitamoto
(K)
Hiroki Yokoyama
(H)
Yuko Yamada
(Y)
Tadashi Sofue
(T)
Tetsuo Minamino
(T)
Emi Ibuki
(E)
Yoshio Terada
(Y)
Taro Horino
(T)
Yoshiko Shimamura
(Y)
Tatsuki Matsumoto
(T)
Mikiya Fujieda
(M)
Masayuki Ishihara
(M)
Shoji Kagami
(S)
Maki Urushihara
(M)
Yukiko Kinoshita
(Y)
Hideharu Abe
(H)
Kojiro Nagai
(K)
Kosuke Masutani
(K)
Tetsuhiko Yasuno
(T)
Kenji Ito
(K)
Ken Hatae
(K)
Manao Nishimura
(M)
Hiroyo Maruyama
(H)
Koji Mitsuiki
(K)
Masashi Mukoyama
(M)
Masataka Adachi
(M)
Kei Fukami
(K)
Junko Yano
(J)
Toshiaki Nakano
(T)
Akihiro Tsuchimoto
(A)
Shunsuke Yamada
(S)
Yuta Matsukuma
(Y)
Yutaka Kiyohara
(Y)
Toshiharu Ninomiya
(T)
Masaharu Nagata
(M)
Naoko Yokota-Ikeda
(N)
Keiko Kodama
(K)
Takashi Taguchi
(T)
Tomoya Nishino
(T)
Yoko Obata
(Y)
Tadashi Uramatsu
(T)
Ritsuko Katafuchi
(R)
Masaru Nakayama
(M)
Ryokichi Yasumori
(R)
Motoaki Miyazono
(M)
Eriko Nonaka
(E)
Shuichi Rikitake
(S)
Makoto Fukuda
(M)
Harumichi Higashi
(H)
Shouichi Fujimoto
(S)
Yuji Sato
(Y)
Masao Kikuchi
(M)
Akihiro Minakawa
(A)
Masahito Tamura
(M)
Tetsu Miyamoto
(T)
Yusuke Ohya
(Y)
Kentaro Kohagura
(K)
Informations de copyright
© 2021. Japanese Society of Nephrology.
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