Fe
DNA
G-quadruplexes
metalo-supramolecular helicates
multitargeted agens
oncogenes
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
11 Aug 2021
11 Aug 2021
Historique:
received:
17
04
2021
pubmed:
29
5
2021
medline:
18
8
2021
entrez:
28
5
2021
Statut:
ppublish
Résumé
DNA G-quadruplexes (G4s) have been identified within the promoter regions of many proto-oncogenes. Thus, G4s represent attractive targets for cancer therapy, and the design and development of new drugs as G4 binders is a very active field of medicinal chemistry. Here, molecular biophysics and biology methods were employed to investigate the interaction of chiral metallohelices with a series of four DNA G4s (hTelo, c-myc, c-kit1, c-kit2) that are formed by the human telomeric sequence (hTelo) and in the promoter regions of c-MYC and c-KIT proto-oncogenes. We show that the investigated water-compatible, optically pure metallohelices, which are made by self-assembly of simple nonpeptidic organic components around Fe
Identifiants
pubmed: 34048082
doi: 10.1002/chem.202101388
doi:
Substances chimiques
Ferrous Compounds
0
MYC protein, human
0
Proto-Oncogene Proteins c-myc
0
DNA
9007-49-2
KIT protein, human
EC 2.7.10.1
Proto-Oncogene Proteins c-kit
EC 2.7.10.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
11682-11692Subventions
Organisme : Grantová Agentura České Republiky
ID : 20-00735S
Informations de copyright
© 2021 Wiley-VCH GmbH.
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