Diverse cellular origins of adult blood vascular endothelial cells.
Bone marrow stromal cells
CAR cells
Endothelial progenitor cells
Epigenetics
Exosomes
GLAST
Hypoxia
Plasticity
Wnt1
scRNA-seq
Journal
Developmental biology
ISSN: 1095-564X
Titre abrégé: Dev Biol
Pays: United States
ID NLM: 0372762
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
17
12
2020
revised:
26
04
2021
accepted:
14
05
2021
pubmed:
29
5
2021
medline:
14
10
2021
entrez:
28
5
2021
Statut:
ppublish
Résumé
During embryonic stages, vascular endothelial cells (ECs) originate from the mesoderm, at specific extraembryonic and embryonic regions, through a process called vasculogenesis. In the adult, EC renewal/replacement mostly depend on local resident ECs or endothelial progenitor cells (EPCs). Nevertheless, contribution from circulating ECs/EPCs was also reported. In addition, cells lacking from EC/EPC markers with in vitro extended plasticity were shown to originate endothelial-like cells (ELCs). Most of these cells consist of mesenchymal stromal progenitors, which would eventually get mobilized from the bone marrow after injury. Based on that, current knowledge on different mouse and human bone marrow stromal cell (BM-SC) subpopulations, able to contribute with mesenchymal stromal/stem cells (MSCs), is herein reviewed. Such analyses underline an unexpected heterogeneity among sinusoidal LepR
Identifiants
pubmed: 34048734
pii: S0012-1606(21)00123-8
doi: 10.1016/j.ydbio.2021.05.010
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
117-132Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.