Maturational trajectories of non-rapid eye movement slow wave activity and odds ratio product in a population-based sample of youth.
Adolescents
Children
Delta power
Odds ratio product
Sleep depth
Slow wave activity
Journal
Sleep medicine
ISSN: 1878-5506
Titre abrégé: Sleep Med
Pays: Netherlands
ID NLM: 100898759
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
25
03
2021
revised:
23
04
2021
accepted:
01
05
2021
pubmed:
29
5
2021
medline:
6
7
2021
entrez:
28
5
2021
Statut:
ppublish
Résumé
Brain maturation is reflected in the sleep electroencephalogram (EEG) by a decline in non-rapid eye movement (NREM) slow wave activity (SWA) throughout adolescence and a related decrease in sleep depth. However, this trajectory and its sex and pubertal differences lack replication in population-based samples. We tested age-related changes in SWA (0.4-4 Hz) power and odds ratio product (ORP), a standardized measure of sleep depth. We analyzed the sleep EEG of 572 subjects aged 6-21 y (48% female, 26% racial/ethnic minority) and 332 subjects 5-12 y followed-up at 12-22 y. Multivariable-adjusted analyses tested age-related cross-sectional and longitudinal trajectories of SWA and ORP. SWA remained stable from age 6 to 10, decreased between ages 11 and 17, and plateaued from age 18 to 21 (p-cubic<0.001); females showed a longitudinal decline 23% greater than males by 13 y, while males experienced a steeper slope after 14 y and their longitudinal decline was 21% greater by 19 y. More mature adolescents (75% female) experienced a greater longitudinal decline in SWA than less mature adolescents by 14 y. ORP showed an age-related increasing trajectory (p-linear<0.001) with no sex or pubertal differences. We provide population-level evidence for the maturational decline and sex and pubertal differences in SWA in the transition from childhood to adolescence, while introducing ORP as a novel metric in youth. Along with previous studies, the distinct trajectories observed suggest that age-related changes in SWA reflect brain maturation and local/synaptic processes during this developmental period, while those of ORP may reflect global/state control of NREM sleep depth.
Sections du résumé
BACKGROUND
Brain maturation is reflected in the sleep electroencephalogram (EEG) by a decline in non-rapid eye movement (NREM) slow wave activity (SWA) throughout adolescence and a related decrease in sleep depth. However, this trajectory and its sex and pubertal differences lack replication in population-based samples. We tested age-related changes in SWA (0.4-4 Hz) power and odds ratio product (ORP), a standardized measure of sleep depth.
METHODS
We analyzed the sleep EEG of 572 subjects aged 6-21 y (48% female, 26% racial/ethnic minority) and 332 subjects 5-12 y followed-up at 12-22 y. Multivariable-adjusted analyses tested age-related cross-sectional and longitudinal trajectories of SWA and ORP.
RESULTS
SWA remained stable from age 6 to 10, decreased between ages 11 and 17, and plateaued from age 18 to 21 (p-cubic<0.001); females showed a longitudinal decline 23% greater than males by 13 y, while males experienced a steeper slope after 14 y and their longitudinal decline was 21% greater by 19 y. More mature adolescents (75% female) experienced a greater longitudinal decline in SWA than less mature adolescents by 14 y. ORP showed an age-related increasing trajectory (p-linear<0.001) with no sex or pubertal differences.
CONCLUSIONS
We provide population-level evidence for the maturational decline and sex and pubertal differences in SWA in the transition from childhood to adolescence, while introducing ORP as a novel metric in youth. Along with previous studies, the distinct trajectories observed suggest that age-related changes in SWA reflect brain maturation and local/synaptic processes during this developmental period, while those of ORP may reflect global/state control of NREM sleep depth.
Identifiants
pubmed: 34049047
pii: S1389-9457(21)00269-0
doi: 10.1016/j.sleep.2021.05.002
pmc: PMC8206023
mid: NIHMS1702996
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
271-279Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL063772
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL097165
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000127
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH118308
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL136587
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
Références
J Sleep Res. 2012 Feb;21(1):59-67
pubmed: 21668552
Sci Rep. 2020 Sep 28;10(1):15935
pubmed: 32985555
J Clin Sleep Med. 2007 Mar 15;3(2):133-45
pubmed: 17557423
J Neurosci. 2011 Apr 27;31(17):6371-8
pubmed: 21525277
Brain Cogn. 2010 Feb;72(1):56-65
pubmed: 19883968
Sleep Med. 2014 Jan;15(1):91-5
pubmed: 24333223
Prog Brain Res. 2011;193:63-82
pubmed: 21854956
Neuropsychopharmacology. 2018 Apr;43(5):937-952
pubmed: 29206811
Ann Am Thorac Soc. 2015 Aug;12(8):1206-18
pubmed: 26065574
Sleep. 2012 Sep 01;35(9):1285-91
pubmed: 22942507
Neuron. 2017 Feb 22;93(4):747-765
pubmed: 28231463
Nature. 2011 Apr 28;472(7344):443-7
pubmed: 21525926
Sleep. 2005 May;28(5):637-43
pubmed: 16171278
Electroencephalogr Clin Neurophysiol. 1988 Feb;69(2):91-9
pubmed: 2446839
Sleep Med Rev. 2006 Feb;10(1):49-62
pubmed: 16376591
Sleep Med. 2020 Feb;66:33-50
pubmed: 31786427
Brain Lang. 2017 Apr;167:3-12
pubmed: 27291337
Dev Psychobiol. 2017 Jan;59(1):5-14
pubmed: 27401676
Sleep Med. 2020 May;69:103-108
pubmed: 32062036
Neuroimage. 2010 Jan 1;49(1):94-103
pubmed: 19679191
Curr Opin Physiol. 2020 Jun;15:210-216
pubmed: 32467862
Vital Health Stat 11. 2002 May;(246):1-190
pubmed: 12043359
Neuropsychol Rev. 2011 Mar;21(1):5-21
pubmed: 21225346
Sleep. 2010 Apr;33(4):475-80
pubmed: 20394316
J Child Psychol Psychiatry. 2019 Jul;60(7):742-751
pubmed: 29989664
J Appl Physiol (1985). 2016 Apr 1;120(7):801-8
pubmed: 26718786
Eur Respir J. 2016 May;47(5):1402-9
pubmed: 26846837
Brain Res. 1979 Mar 16;163(2):195-205
pubmed: 427544
Sleep. 2016 May 01;39(5):1029-36
pubmed: 26951400
Neural Plast. 2017;2017:6160959
pubmed: 28845310
Nat Neurosci. 1999 Oct;2(10):861-3
pubmed: 10491603
J Comp Neurol. 2005 Dec 5;493(1):92-8
pubmed: 16254994
Sleep. 2018 Oct 1;41(10):
pubmed: 29986077
Am J Physiol Regul Integr Comp Physiol. 2006 Dec;291(6):R1724-9
pubmed: 16857890
Cereb Cortex. 2011 Mar;21(3):607-15
pubmed: 20624840
Sleep. 2015 Apr 01;38(4):641-54
pubmed: 25348125
Sleep. 2010 Jun;33(6):801-9
pubmed: 20550021
J Clin Sleep Med. 2016 Oct 15;12(10):1347-1356
pubmed: 27448418
Hypertension. 2008 Nov;52(5):841-6
pubmed: 18838624
Front Neurosci. 2019 Aug 20;13:813
pubmed: 31481865
PLoS One. 2013 May 29;8(5):e65098
pubmed: 23734235
Sleep. 2013 Apr 01;36(4):573-82
pubmed: 23565003
Neuroimage. 2012 Nov 1;63(2):959-65
pubmed: 22498654
Biol Psychiatry. 2000 Nov 15;48(10):1010-9
pubmed: 11082476
J Neurosci. 2010 Oct 6;30(40):13211-9
pubmed: 20926647
J Clin Sleep Med. 2016 Jun 15;12(6):885-94
pubmed: 27070243
Sleep. 2020 Dec 14;43(12):
pubmed: 32729619
Brain Struct Funct. 2018 Mar;223(2):669-685
pubmed: 28913599
Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5177-80
pubmed: 19307577
Brain Behav Immun. 2017 Mar;61:110-116
pubmed: 28041986
J Adolesc Health. 1993 May;14(3):190-5
pubmed: 8323929
Psychiatry Clin Neurosci. 2001 Jun;55(3):305-10
pubmed: 11422885
Nat Neurosci. 2013 Apr;16(4):391-3
pubmed: 23434910
Am J Physiol Regul Integr Comp Physiol. 2013 Feb 15;304(4):R296-303
pubmed: 23193115
Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5740-3
pubmed: 22451933
J Sleep Res. 2001 Sep;10(3):165-72
pubmed: 11696069