Efficacy of Chinese patent medicine for primary osteoporosis: A network meta-analysis.
Chinese patent medicine
Network meta-analysis
Primary osteoporosis
Traditional Chinese medicine
Journal
Complementary therapies in clinical practice
ISSN: 1873-6947
Titre abrégé: Complement Ther Clin Pract
Pays: England
ID NLM: 101225531
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
31
08
2020
revised:
03
03
2021
accepted:
16
05
2021
pubmed:
29
5
2021
medline:
4
8
2021
entrez:
28
5
2021
Statut:
ppublish
Résumé
Chinese patent medicines (CPMs) have gained increasing attention for the treatment of primary osteoporosis (POP), but there is a lack of high-quality evidence regarding their efficacy. We conducted a network meta-analysis that considered both direct and indirect comparisons to assess and rank the efficacy and safety of CPMs for POP. Seven electronic databases were searched from their inception to May 2020. A random effects model was applied within a frequentist framework. Thirty-eight studies with 16 kinds of medicines (13 CPMs, 3 Western medicines) and 3,941 patients were included in this study. This study showed that Jintiange capsule was the most efficacious for increasing the L2-L4 average bone mineral density (BMD) and that Zuogui Wan was the most efficacious for increasing the femoral neck BMD. Compared with calcium, Gusongjiangu Wan (RR = 10.04, 95% CI 1.36-74.32, p = 0.008), Gushukang granules (RR = 12.63, 95% CI 2.02-78.99, p = 0.015) and Xianling Gubao capsule (RR = 6.06, 95% CI 1.38-26.65, p = 0.0003) had fewer adverse reactions. In the treatment of POP, Jintiange capsule and Zuogui Wan are effective CPMs for improving the BMD of the lumbar spine and femoral neck, respectively.
Sections du résumé
BACKGROUND AND PURPOSE
OBJECTIVE
Chinese patent medicines (CPMs) have gained increasing attention for the treatment of primary osteoporosis (POP), but there is a lack of high-quality evidence regarding their efficacy. We conducted a network meta-analysis that considered both direct and indirect comparisons to assess and rank the efficacy and safety of CPMs for POP.
METHODS
METHODS
Seven electronic databases were searched from their inception to May 2020. A random effects model was applied within a frequentist framework.
RESULTS
RESULTS
Thirty-eight studies with 16 kinds of medicines (13 CPMs, 3 Western medicines) and 3,941 patients were included in this study. This study showed that Jintiange capsule was the most efficacious for increasing the L2-L4 average bone mineral density (BMD) and that Zuogui Wan was the most efficacious for increasing the femoral neck BMD. Compared with calcium, Gusongjiangu Wan (RR = 10.04, 95% CI 1.36-74.32, p = 0.008), Gushukang granules (RR = 12.63, 95% CI 2.02-78.99, p = 0.015) and Xianling Gubao capsule (RR = 6.06, 95% CI 1.38-26.65, p = 0.0003) had fewer adverse reactions.
CONCLUSION
CONCLUSIONS
In the treatment of POP, Jintiange capsule and Zuogui Wan are effective CPMs for improving the BMD of the lumbar spine and femoral neck, respectively.
Identifiants
pubmed: 34049211
pii: S1744-3881(21)00118-3
doi: 10.1016/j.ctcp.2021.101419
pii:
doi:
Substances chimiques
Biological Products
0
Nonprescription Drugs
0
jintiange
0
Types de publication
Journal Article
Meta-Analysis
Review
Langues
eng
Pagination
101419Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.