Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I.
Auditory processing
Autism spectrum disorder
Change detection
EEG
Habituation
Neurofibromatosis type 1
Journal
Journal of neurodevelopmental disorders
ISSN: 1866-1955
Titre abrégé: J Neurodev Disord
Pays: England
ID NLM: 101483832
Informations de publication
Date de publication:
28 05 2021
28 05 2021
Historique:
received:
16
06
2020
accepted:
03
04
2021
entrez:
29
5
2021
pubmed:
30
5
2021
medline:
27
8
2021
Statut:
epublish
Résumé
Sensory modulation difficulties are common in children with conditions such as Autism Spectrum Disorder (ASD) and could contribute to other social and non-social symptoms. Positing a causal role for sensory processing differences requires observing atypical sensory reactivity prior to the emergence of other symptoms, which can be achieved through prospective studies. In this longitudinal study, we examined auditory repetition suppression and change detection at 5 and 10 months in infants with and without Neurofibromatosis Type 1 (NF1), a condition associated with higher likelihood of developing ASD. In typically developing infants, suppression to vowel repetition and enhanced responses to vowel/pitch change decreased with age over posterior regions, becoming more frontally specific; age-related change was diminished in the NF1 group. Whilst both groups detected changes in vowel and pitch, the NF1 group were largely slower to show a differentiated neural response. Auditory responses did not relate to later language, but were related to later ASD traits. These findings represent the first demonstration of atypical brain responses to sounds in infants with NF1 and suggest they may relate to the likelihood of later ASD.
Sections du résumé
BACKGROUND
Sensory modulation difficulties are common in children with conditions such as Autism Spectrum Disorder (ASD) and could contribute to other social and non-social symptoms. Positing a causal role for sensory processing differences requires observing atypical sensory reactivity prior to the emergence of other symptoms, which can be achieved through prospective studies.
METHODS
In this longitudinal study, we examined auditory repetition suppression and change detection at 5 and 10 months in infants with and without Neurofibromatosis Type 1 (NF1), a condition associated with higher likelihood of developing ASD.
RESULTS
In typically developing infants, suppression to vowel repetition and enhanced responses to vowel/pitch change decreased with age over posterior regions, becoming more frontally specific; age-related change was diminished in the NF1 group. Whilst both groups detected changes in vowel and pitch, the NF1 group were largely slower to show a differentiated neural response. Auditory responses did not relate to later language, but were related to later ASD traits.
CONCLUSIONS
These findings represent the first demonstration of atypical brain responses to sounds in infants with NF1 and suggest they may relate to the likelihood of later ASD.
Identifiants
pubmed: 34049498
doi: 10.1186/s11689-021-09364-3
pii: 10.1186/s11689-021-09364-3
pmc: PMC8161667
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
22Subventions
Organisme : Medical Research Council
ID : MR/T003057/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0401546
Pays : United Kingdom
Investigateurs
Rebecca Holman
(R)
Sarah Kalwarowsky
(S)
Laura Pirazzoli
(L)
Chloë Taylor
(C)
Grace Vassallo
(G)
Emma Burkitt-Wright
(E)
Judith Eelloo
(J)
D Gareth Evans
(DG)
Siobhan West
(S)
Eileen Hupton
(E)
Lauren Lewis
(L)
Louise Robinson
(L)
Angus Dobbie
(A)
Ruth Drimer
(R)
Saghira Malik Sharif
(SM)
Helen Bethell
(H)
Rachel Jones
(R)
Susan Musson
(S)
Catherine Prem
(C)
Miranda Splitt
(M)
Karen Horridge
(K)
Diana Baralle
(D)
Carolyn Redman
(C)
Helen Tomkins
(H)
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