Calcium-dependent docking of synaptic vesicles.

Calcium Exocytosis Humans Presynaptic Terminals Synaptic Transmission Synaptic Vesicles
SNARE proteins active zone short-term synaptic plasticity synaptic vesicles synaptotagmin vesicle docking

Journal

Trends in neurosciences
ISSN: 1878-108X
Titre abrégé: Trends Neurosci
Pays: England
ID NLM: 7808616

Informations de publication

Date de publication:
07 2021
Historique:
received: 04 12 2020
revised: 23 02 2021
accepted: 09 04 2021
pubmed: 30 5 2021
medline: 19 8 2021
entrez: 29 5 2021
Statut: ppublish

Résumé

The concentration of calcium ions in presynaptic terminals regulates transmitter release, but underlying mechanisms have remained unclear. Here we review recent studies that shed new light on this issue. Fast-freezing electron microscopy and total internal reflection fluorescence microscopy studies reveal complex calcium-dependent vesicle movements including docking on a millisecond time scale. Recordings from so-called 'simple synapses' indicate that calcium not only triggers exocytosis, but also modifies synaptic strength by controlling a final, rapid vesicle maturation step before release. Molecular studies identify several calcium-sensitive domains on Munc13 and on synaptotagmin-1 that are likely involved in bringing the vesicular and plasma membranes closer together in response to calcium elevation. Together, these results suggest that calcium-dependent vesicle docking occurs in a wide range of time domains and plays a crucial role in several phenomena including synaptic facilitation, post-tetanic potentiation, and neuromodulator-induced potentiation.

Identifiants

DOI: 10.1016/j.tins.2021.04.003 PMID: 34049722
pubmed: 34049722
pii: S0166-2236(21)00075-8
doi: 10.1016/j.tins.2021.04.003
pii:
doi:

Substances chimiques

Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

579-592

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests in relation to this work.

Auteurs

Melissa Silva (M)

Université de Paris, SPPIN-Saints Pères Paris Institute for the Neurosciences, CNRS, F-75006 Paris, France.

Van Tran (V)

Université de Paris, SPPIN-Saints Pères Paris Institute for the Neurosciences, CNRS, F-75006 Paris, France.

Alain Marty (A)

Université de Paris, SPPIN-Saints Pères Paris Institute for the Neurosciences, CNRS, F-75006 Paris, France. Electronic address: alain.marty@parisdescartes.fr.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Calcium-dependent docking of synaptic vesicles.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Exocytose › Calcium-dependent docking of synaptic vesicles.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Calcium-dependent docking of synaptic vesicles.
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › Terminaisons présynaptiques › Calcium-dependent docking of synaptic vesicles.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Calcium-dependent docking of synaptic vesicles.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Vésicules de sécrétion › Vésicules synaptiques › Calcium-dependent docking of synaptic vesicles.