Gene-Environment Interactions in Multiple Sclerosis: A UK Biobank Study.
Adult
Aged
Biological Specimen Banks
Case-Control Studies
Female
Gene-Environment Interaction
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Longitudinal Studies
Male
Middle Aged
Multifactorial Inheritance
/ genetics
Multiple Sclerosis
/ epidemiology
Pediatric Obesity
/ complications
Risk Factors
United Kingdom
/ epidemiology
Journal
Neurology(R) neuroimmunology & neuroinflammation
ISSN: 2332-7812
Titre abrégé: Neurol Neuroimmunol Neuroinflamm
Pays: United States
ID NLM: 101636388
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
30
11
2020
accepted:
16
03
2021
entrez:
29
5
2021
pubmed:
30
5
2021
medline:
22
1
2022
Statut:
epublish
Résumé
We sought to determine whether genetic risk modifies the effect of environmental risk factors for multiple sclerosis (MS). To test this hypothesis, we tested for statistical interaction between polygenic risk scores (PRS) capturing genetic susceptibility to MS and environmental risk factors for MS in UK Biobank. People with MS were identified within UK Biobank using Data were available for 2,250 people with MS and 486,000 controls. Childhood obesity, earlier age at menarche, and smoking were associated with MS. The optimal PRS were strongly associated with MS in the validation cohort (PRS This study provides novel evidence for an interaction between childhood obesity and a high burden of autosomal genetic risk. These findings may have significant implications for our understanding of MS biology and inform targeted prevention strategies.
Identifiants
pubmed: 34049995
pii: 8/4/e1007
doi: 10.1212/NXI.0000000000001007
pmc: PMC8192056
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Informations de copyright
Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
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