Distinct contribution of cone photoreceptor subtypes to the mammalian biological clock.
circadian
cones
in vivo electrophysiology
photoentrainment
suprachiasmatic nucleus
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
01 06 2021
01 06 2021
Historique:
entrez:
29
5
2021
pubmed:
30
5
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Ambient light detection is important for the synchronization of the circadian clock to the external solar cycle. Light signals are sent to the suprachiasmatic nuclei (SCN), the site of the major circadian pacemaker. It has been assumed that cone photoreceptors contribute minimally to synchronization. Here, however, we find that cone photoreceptors are sufficient for mediating entrainment and transmitting photic information to the SCN, as evaluated in mice that have only cones as functional photoreceptors. Using in vivo electrophysiological recordings in the SCN of freely moving cone-only mice, we observed light responses in SCN neuronal activity in response to 60-s pulses of both ultraviolet (UV) (λ
Identifiants
pubmed: 34050024
pii: 2024500118
doi: 10.1073/pnas.2024500118
pmc: PMC8179201
pii:
doi:
Substances chimiques
Gnat1 protein, mouse
0
Rod Opsins
0
melanopsin
0
Transducin
EC 3.6.5.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2021 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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