Skeletal endocrinology: where evolutionary advantage meets disease.
Journal
Bone research
ISSN: 2095-4700
Titre abrégé: Bone Res
Pays: China
ID NLM: 101608652
Informations de publication
Date de publication:
28 May 2021
28 May 2021
Historique:
received:
13
10
2020
accepted:
23
02
2021
revised:
16
02
2021
entrez:
29
5
2021
pubmed:
30
5
2021
medline:
30
5
2021
Statut:
epublish
Résumé
The regulation of whole-body homeostasis by the skeleton is mediated by its capacity to secrete endocrine signaling molecules. Although bone-derived hormones confer several adaptive benefits, their physiological functions also involve trade-offs, thus eventually contributing to disease. In this manuscript, we discuss the origins and functions of two of the best-studied skeletal mediators, fibroblast growth factor 23 and osteocalcin, in an evolutionary context. Moreover, we provide a theoretical framework seeking to explain the broad involvement of these two hormones in amniote physiology as well as their potential to fuel the development and progression of diseases. Vice versa, we outline which perturbations might be amenable to manipulation of these systems and discuss limitations and ongoing challenges in skeletal endocrine research. Finally, we summarize unresolved questions and potential future studies in this thriving field.
Identifiants
pubmed: 34050126
doi: 10.1038/s41413-021-00149-x
pii: 10.1038/s41413-021-00149-x
pmc: PMC8163738
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
28Subventions
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : RA1923/12-1
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : RA 2151/4-1
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