Rapid brain structure and tumour margin detection on whole frozen tissue sections by fast multiphotometric mid-infrared scanning.
Animals
Carcinoma, Hepatocellular
/ diagnostic imaging
Diagnostic Imaging
/ methods
Fourier Analysis
Frozen Sections
/ methods
High-Throughput Screening Assays
/ methods
Humans
Liver Neoplasms
/ diagnostic imaging
Margins of Excision
Mice
Radionuclide Imaging
/ methods
Spectrophotometry, Infrared
/ instrumentation
Spectroscopy, Fourier Transform Infrared
/ methods
Workflow
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
28 05 2021
28 05 2021
Historique:
received:
27
01
2021
accepted:
17
05
2021
entrez:
29
5
2021
pubmed:
30
5
2021
medline:
20
11
2021
Statut:
epublish
Résumé
Frozen section analysis is a frequently used method for examination of tissue samples, especially for tumour detection. In the majority of cases, the aim is to identify characteristic tissue morphologies or tumour margins. Depending on the type of tissue, a high number of misdiagnoses are associated with this process. In this work, a fast spectroscopic measurement device and workflow was developed that significantly improves the speed of whole frozen tissue section analyses and provides sufficient information to visualize tissue structures and tumour margins, dependent on their lipid and protein molecular vibrations. That optical and non-destructive method is based on selected wavenumbers in the mid-infrared (MIR) range. We present a measuring system that substantially outperforms a commercially available Fourier Transform Infrared (FT-IR) Imaging system, since it enables acquisition of reduced spectral information at a scan field of 1 cm
Identifiants
pubmed: 34050224
doi: 10.1038/s41598-021-90777-4
pii: 10.1038/s41598-021-90777-4
pmc: PMC8163866
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11307Références
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