The relation between acute changes in the systemic inflammatory response and circulating thiamine and magnesium concentrations after elective knee arthroplasty.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
28 05 2021
28 05 2021
Historique:
received:
18
07
2020
accepted:
10
05
2021
entrez:
29
5
2021
pubmed:
30
5
2021
medline:
20
11
2021
Statut:
epublish
Résumé
Thiamine diphosphate (TDP) and magnesium are co-factors for key enzymes in human intermediary metabolism. However, their role in the systemic inflammatory response (SIR) is not clear. Therefore, the aim of the present study was to examine the relation between acute changes in the SIR and thiamine and magnesium dependent enzyme activity in patients undergoing elective knee arthroplasty (a standard reproducible surgical injury in apparently healthy individuals). Patients (n = 35) who underwent elective total knee arthroplasty had venous blood samples collected pre- and post-operatively for 3 days, for measurement of whole blood TDP, serum and erythrocyte magnesium, erythrocyte transketolase activity (ETKA), lactate dehydrogenase (LDH), glucose and lactate concentrations. Pre-operatively, TDP concentrations, erythrocyte magnesium concentrations, ETKA and plasma glucose were within normal limits for all patients. In contrast, 5 patients (14%) had low serum magnesium concentrations (< 0.75 mmol/L). On post-operative day1, both TDP concentrations (p < 0.001) and basal ETKA (p < 0.05) increased and serum magnesium concentrations decreased (p < 0.001). Erythrocyte magnesium concentrations correlated with serum magnesium concentrations (r
Identifiants
pubmed: 34050237
doi: 10.1038/s41598-021-90591-y
pii: 10.1038/s41598-021-90591-y
pmc: PMC8163855
doi:
Substances chimiques
Transketolase
EC 2.2.1.1
Magnesium
I38ZP9992A
Thiamine Pyrophosphate
Q57971654Y
Thiamine
X66NSO3N35
Banques de données
ClinicalTrials.gov
['NCT03554668']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11271Références
Curr Opin Clin Nutr Metab Care. 2017 Nov;20(6):504-511
pubmed: 28806179
Biochem Biophys Res Commun. 1975 Apr 21;63(4):924-30
pubmed: 1093550
Alcohol Alcohol. 1998 Jul-Aug;33(4):317-36
pubmed: 9719389
J Thorac Dis. 2016 Jul;8(7):E552-7
pubmed: 27501325
Nutrients. 2017 Mar 17;9(3):
pubmed: 28304338
Open Heart. 2018 Jan 13;5(1):e000668
pubmed: 29387426
Immunity. 2017 Sep 19;47(3):406-420
pubmed: 28930657
FEBS Lett. 2005 May 9;579(12):2583-8
pubmed: 15862294
Clin Kidney J. 2012 Feb;5(Suppl 1):i3-i14
pubmed: 26069819
Int J Vitam Nutr Res. 2006 Nov;76(6):343-51
pubmed: 17607953
Clin Nutr ESPEN. 2017 Feb;17:54-62
pubmed: 28361748
Adv Nutr. 2016 Nov 15;7(6):977-993
pubmed: 28140318
Clin Nutr. 2004 Oct;23(5):1080-3
pubmed: 15380899
J Intensive Care Med. 2016 Mar;31(3):187-92
pubmed: 24733810
Nutrients. 2018 Sep 01;10(9):
pubmed: 30200431
Sci Rep. 2017 Dec 20;7(1):17913
pubmed: 29263344
Am J Clin Nutr. 2014 Sep;100(3):756-64
pubmed: 25030784
Am J Nephrol. 2016;44(5):381-387
pubmed: 27771720
Clin Nutr ESPEN. 2018 Jun;25:8-17
pubmed: 29779823
N Engl J Med. 1999 Feb 11;340(6):448-54
pubmed: 9971870
Clin Chem. 2000 May;46(5):704-10
pubmed: 10794754
Adv Nutr. 2016 Jan 15;7(1):25-43
pubmed: 26773013
Int J Mol Sci. 2018 Jan 05;19(1):
pubmed: 29303978
Am J Clin Nutr. 2011 May;93(5):1006-11
pubmed: 21411617
Ann N Y Acad Sci. 2018 Oct;1430(1):3-43
pubmed: 30151974
Adv Nutr. 2015 Mar 13;6(2):147-53
pubmed: 25770253
Chest. 2017 Jun;151(6):1229-1238
pubmed: 27940189
JAMA. 1992 Dec 23-30;268(24):3452-5
pubmed: 1460735
Clin Chem. 1976 Mar;22(3):327-35
pubmed: 1253408
J Crit Care. 2020 Jun;57:231-239
pubmed: 32061462
Am J Clin Nutr. 2011 Jan;93(1):57-61
pubmed: 21068344
Clin Transl Gastroenterol. 2015 Jun 18;6:e91
pubmed: 26087059
Proc Nutr Soc. 2019 Feb;78(1):56-67
pubmed: 30220267
Scott Med J. 2013 Aug;58(3):139-42
pubmed: 23960051
Curr Opin Clin Nutr Metab Care. 2011 Nov;14(6):610-7
pubmed: 21912244
Nutrition. 2010 Jan;26(1):133-6
pubmed: 20005469
Clin Chim Acta. 1985 Nov 29;153(1):43-8
pubmed: 4075519
MedGenMed. 2006 Dec 19;8(4):59
pubmed: 17415336
Clin Nutr. 2005 Dec;24(6):956-60
pubmed: 16054730
Clin Nutr. 2018 Oct;37(5):1541-1549
pubmed: 28890274
Am J Nephrol. 2016;44(5):379-380
pubmed: 27771706
Biochem Biophys Res Commun. 1971 Jun 4;43(5):1198-203
pubmed: 4327957
Ann Clin Biochem. 1988 Nov;25 ( Pt 6):698-705
pubmed: 3254112
Folia Neuropathol. 2013;51(3):222-6
pubmed: 24114639
J Crit Care. 2014 Apr;29(2):214-8
pubmed: 24388658
Intensive Care Med. 1988;14(4):384-7
pubmed: 3136196
Med Hypotheses. 2015 Feb;84(2):129-34
pubmed: 25542071