Dietary vitamin D intake and colorectal cancer risk: a longitudinal approach within the PREDIMED study.

Aged Cardiovascular Diseases / epidemiology Colorectal Neoplasms / epidemiology Female Humans Male Prospective Studies Risk Factors Vitamin D
Cancer Colorectal cancer PREDIMED Risk Vitamin D

Journal

European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704

Informations de publication

Date de publication:
Dec 2021
Historique:
received: 03 02 2021
accepted: 11 05 2021
pubmed: 30 5 2021
medline: 10 11 2021
entrez: 29 5 2021
Statut: ppublish

Résumé

We evaluated whether the intake of dietary vitamin D is associated with the incidence of both colorectal cancer (CRC) and colon cancer in the framework of the PREDIMED cohort of older adults at high cardiovascular risk. We analyzed data from 7216 men and women (55-80 years) without CRC at baseline from the PREvención con DIeta MEDiterránea study. Baseline consumption of vitamin D was assessed using a validated 137-item food frequency questionnaire. Cox proportional hazards ratios (HRs) of CRC and colon cancer incidence were estimated for quartiles and per 1-SD of baseline vitamin D intake. During a median follow-up of 6 years, we documented 97 incident CRC cases after the exclusion of subjects with no baseline dietary data and/or outliers of energy intake. A non-significant HRs and 95% confidence intervals (CIs) of CRC for the comparison of extreme quartiles (4th vs 1st) of vitamin D intake were observed [0.55 (0.30-1.00), P for trend = 0.072], whereas it was significant for colon cancer incidence alone [0.44 (0.22-0.90), P for trend = 0.032]. However, this association became significant in CRC and colon cancer incidence, after excluding 391 subjects consuming baseline vitamin D and/or calcium medication or prescribed supplements [0.52 (0.28-0.96) and 0.41 (0.12-0.85), respectively]. A higher dietary intake of vitamin D was significantly associated with a reduced CRC risk in individuals at high cardiovascular risk.

Identifiants

DOI: 10.1007/s00394-021-02585-1 PMID: 34050394
pubmed: 34050394
doi: 10.1007/s00394-021-02585-1
pii: 10.1007/s00394-021-02585-1
doi:

Substances chimiques

Vitamin D 1406-16-2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4367-4378

Subventions

Organisme : Ministerio de Ciencia, Innovación y Universidades
ID : FJCI-2017-32205
Organisme : Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla
ID : RC-0001-2018
Organisme : Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla
ID : C-0029-2023

Informations de copyright

© 2021. Springer-Verlag GmbH Germany, part of Springer Nature.

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Auteurs

Pablo Hernández-Alonso (P)

Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Unitat de Nutrició Humana, C/Sant Llorenç 21, 43201, Reus, Spain.
Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari San Joan de Reus, 43204, Reus, Spain.
Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Institute of Biomedical Research in Malaga (IBIMA), University of Malaga, 29016, Málaga, Spain.
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.
ORCID: 0000-0002-9977-8976

Silvia Canudas (S)

Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Unitat de Nutrició Humana, C/Sant Llorenç 21, 43201, Reus, Spain.
Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari San Joan de Reus, 43204, Reus, Spain.
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.

Hatim Boughanem (H)

Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Institute of Biomedical Research in Malaga (IBIMA), University of Malaga, 29016, Málaga, Spain.

Estefanía Toledo (E)

Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.
Department of Preventive Medicine and Public Health, Universidad de Navarra, 31008, Pamplona, Spain.
IdiSNA, Navarra Institute for Health Research, 31008, Pamplona, Spain.

Jose V Sorlí (JV)

Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.
Department of Preventive Medicine, Universidad de Valencia, 46010, Valencia, Spain.

Ramón Estruch (R)

Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.
Cardiovascular Risk, Nutrition and Aging Research Unit, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08003, Barcelona, Spain.
Internal Medicine Service, Hospital Clínic, 08036, Barcelona, Spain.

Olga Castañer (O)

Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.
Cardiovascular Risk and Nutrition Research Group, Hospital del Mar Medical Research Institute (IMIM), 08003, Barcelona, Spain.

José Lapetra (J)

Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.
Department of Family Medicine, Research Unit, Distrito Sanitario Atención Primaria Sevilla, 41013, Sevilla, Spain.

Angel M Alonso-Gómez (AM)

Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.
Bioaraba Health Research Institute, Osakidetza Basque Health Service, Araba University Hospital, University of the Basque Country UPV/EHU, 01002, Vitoria-Gasteiz, Spain.

Mario Gutiérrez-Bedmar (M)

Department of Preventive Medicine and Public Health, School of Medicine, Instituto de Investigación Biomédica de Málaga-IBIMA, Universidad de Málaga, 29010, Málaga, Spain.

Miquel Fiol (M)

Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.
Health Research Institute of the Balearic Islands (IdISBa), Hospital Son Espases, 07120, Palma de Mallorca, Spain.

Lluis Serra-Majem (L)

Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.
Institute for Biomedical and Health Research, Universidad de Las Palmas de Gran Canaria, 35016, Las Palmas, Spain.

Xavier Pintó (X)

Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.
Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge-Idibell, 08907, L'Hospitalet de Llobregat, Spain.

Emilio Ros (E)

Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.
Lipid Clinic, Department of Endocrinology and Nutrition Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain.

Cesar I Fernandez-Lazaro (CI)

Department of Preventive Medicine and Public Health, Universidad de Navarra, 31008, Pamplona, Spain.

Judith B Ramirez-Sabio (JB)

Servicio de Oncología, Hospital de Sagunto, 46520, Valencia, Spain.

Montse Fitó (M)

Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.
Cardiovascular Risk and Nutrition Research Group, Hospital del Mar Medical Research Institute (IMIM), 08003, Barcelona, Spain.

Joseba Portu-Zapirain (J)

Bioaraba, Infectious Diseases Research Group, Vitoria-Gasteiz, Spain.
Internal Medicine Department, Osakidetza Basque Health Service, Araba University Hospital, Vitoria-Gasteiz, Spain.

Manuel Macias-González (M)

Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Institute of Biomedical Research in Malaga (IBIMA), University of Malaga, 29016, Málaga, Spain. mmacias.manuel@gmail.com.
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain. mmacias.manuel@gmail.com.
ORCID: 0000-0002-6475-4704

Nancy Babio (N)

Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Unitat de Nutrició Humana, C/Sant Llorenç 21, 43201, Reus, Spain. nancy.babio@urv.cat.
Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari San Joan de Reus, 43204, Reus, Spain. nancy.babio@urv.cat.
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain. nancy.babio@urv.cat.
ORCID: 0000-0003-3527-5277

Jordi Salas-Salvadó (J)

Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Unitat de Nutrició Humana, C/Sant Llorenç 21, 43201, Reus, Spain.
Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari San Joan de Reus, 43204, Reus, Spain.
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Dietary vitamin D intake and colorectal cancer...
questionsmedicales.fr › Maladies cardiovasculaires › Dietary vitamin D intake and colorectal cancer...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Dietary vitamin D intake and colorectal cancer...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dietary vitamin D intake and colorectal cancer...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Dietary vitamin D intake and colorectal cancer...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Dietary vitamin D intake and colorectal cancer...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Sécostéroïdes › Vitamine D › Dietary vitamin D intake and colorectal cancer...