Clonal hematopoiesis associated with epigenetic aging and clinical outcomes.

Aging Clonal Hematopoiesis / genetics Epigenomics / methods Humans Risk Factors Treatment Outcome
clonal hematopoiesis epigenomics heart disease

Journal

Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839

Informations de publication

Date de publication:
06 2021
Historique:
revised: 11 03 2021
received: 09 12 2020
accepted: 27 03 2021
pubmed: 30 5 2021
medline: 29 12 2021
entrez: 29 5 2021
Statut: ppublish

Résumé

Clonal hematopoiesis of indeterminate potential (CHIP) is a common precursor state for blood cancers that most frequently occurs due to mutations in the DNA-methylation modifying enzymes DNMT3A or TET2. We used DNA-methylation array and whole-genome sequencing data from four cohorts together comprising 5522 persons to study the association between CHIP, epigenetic clocks, and health outcomes. CHIP was strongly associated with epigenetic age acceleration, defined as the residual after regressing epigenetic clock age on chronological age, in several clocks, ranging from 1.31 years (GrimAge, p < 8.6 × 10

Identifiants

DOI: 10.1111/acel.13366 PMID: 34050697 PMC: PMC8208788
pubmed: 34050697
doi: 10.1111/acel.13366
pmc: PMC8208788
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e13366

Subventions

Organisme : NHLBI NIH HHS
ID : HHSN268201500003C
Pays : United States
Organisme : NIA NIH HHS
ID : 1T32AG047126-01
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL071250
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG000040
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800014C
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007208
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600003C
Pays : United States
Organisme : NIDA NIH HHS
ID : 75N95020D00007
Pays : United States
Organisme : NIH HHS
ID : 75N98020D00007
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG047126
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001881
Pays : United States
Organisme : NIDA NIH HHS
ID : 75N95020D00004
Pays : United States
Organisme : ORFDO NIH HHS
ID : 75N99020D00004
Pays : United States
Organisme : NIDA NIH HHS
ID : 75N95020D00003
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100037C
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR033176
Pays : United States
Organisme : CLC NIH HHS
ID : 75N90020D00002
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800012C
Pays : United States
Organisme : NIH HHS
ID : DP5 OD029586
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL071251
Pays : United States
Organisme : NHGRI NIH HHS
ID : U54 HG003067
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG060908
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600002C
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL071259
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151283
Pays : United States
Organisme : NIEHS NIH HHS
ID : 75N96020D00002
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600018C
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL092577
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93020D00002
Pays : United States
Organisme : ORFDO NIH HHS
ID : 75N99020D00003
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148565
Pays : United States
Organisme : NIDA NIH HHS
ID : 75N95020D00002
Pays : United States
Organisme : CLC NIH HHS
ID : 75N90020D00003
Pays : United States
Organisme : NIEHS NIH HHS
ID : 75N96020D00003
Pays : United States
Organisme : ORFDO NIH HHS
ID : 75N99020D00002
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063491
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL071051
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800001C
Pays : United States
Organisme : NIMHD NIH HHS
ID : HHSN268201800013I
Pays : United States
Organisme : ORFDO NIH HHS
ID : 75N99020D00006
Pays : United States
Organisme : NIDA NIH HHS
ID : 75N95020D00005
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600004C
Pays : United States
Organisme : NHLBI NIH HHS
ID : DP2 HL157540
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800011C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500014C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500003I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600001C
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92021D00006
Pays : United States
Organisme : ORFDO NIH HHS
ID : 75N99020D00005
Pays : United States
Organisme : ORFDO NIH HHS
ID : 75N99020D00007
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800015I
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL071205
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL071258
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148050
Pays : United States

Informations de copyright

© 2021 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

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Auteurs

Daniel Nachun (D)

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
ORCID: 0000-0002-0271-1135

Ake T Lu (AT)

Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Alexander G Bick (AG)

Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.

Pradeep Natarajan (P)

Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Broad Institute, Cambridge, MA, USA.

Joshua Weinstock (J)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Mindy D Szeto (MD)

Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Sekar Kathiresan (S)

Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Broad Institute, Cambridge, MA, USA.

Goncalo Abecasis (G)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Kent D Taylor (KD)

Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.

Xiuqing Guo (X)

Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.

Russ Tracy (R)

Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA.

Peter Durda (P)

Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA.

Yongmei Liu (Y)

Department of Medicine, Duke University Medical Center, Durham, NC, USA.

Craig Johnson (C)

Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.

Stephen S Rich (SS)

Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.

David Van Den Berg (D)

Department of Clinical Preventative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Cecilia Laurie (C)

Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.

Tom Blackwell (T)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

George J Papanicolaou (GJ)

Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.

Adolfo Correa (A)

Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.

Laura M Raffield (LM)

Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

Andrew D Johnson (AD)

National Heart Lung and Blood Institute, Framingham, MA, USA.
ORCID: 0000-0001-6369-5178

Joanne Murabito (J)

Department of Medicine, Boston University School of Medicine, Boston, MA, USA.

JoAnn E Manson (JE)

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Pinkal Desai (P)

Department of Hematology/Oncology, Joan & Sanford I. Weill Medical College of Cornell University, New York, NY, USA.

Charles Kooperberg (C)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Themistocles L Assimes (TL)

Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Daniel Levy (D)

National Heart Lung and Blood Institute, Framingham, MA, USA.

Jerome I Rotter (JI)

Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.

Alex P Reiner (AP)

Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.

Eric A Whitsel (EA)

Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Department of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC, USA.

James G Wilson (JG)

Department of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.

Steve Horvath (S)

Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
ORCID: 0000-0002-4110-3589

Siddhartha Jaiswal (S)

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Clonal hematopoiesis associated with...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hématopoïèse › Hématopoïèse clonale › Clonal hematopoiesis associated with...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Épigénomique › Clonal hematopoiesis associated with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Clonal hematopoiesis associated with...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Clonal hematopoiesis associated with...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Clonal hematopoiesis associated with...