Effect of periodontal treatment on preclinical Alzheimer's disease-Results of a trial emulation approach.
Alzheimer's disease
aging
epidemiology
magnetic resonance imaging
periodontal diseases
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
20
04
2021
received:
22
12
2020
accepted:
20
04
2021
pubmed:
30
5
2021
medline:
11
3
2022
entrez:
29
5
2021
Statut:
ppublish
Résumé
We investigated the relationship between periodontal treatment and pre-clinical Alzheimer's disease (AD). In this quasi-experimental design, 177 periodontally treated patients from the "Greifswald Approach to Individualized Medicine" cohort, which used the same protocols as the population-based Study of Health in Pomerania TREND (SHIP-TREND), and 409 untreated subjects from SHIP-TREND were analyzed. Subjects were younger than 60 years at the magnetic resonance imaging examination, with a median observation period of 7.3 years. Imaging markers for brain atrophy in late-onset AD and brain aging were used as the outcomes. Robust to sensitivity analyses, periodontal treatment had a favorable effect on AD-related brain atrophy (-0.41; 95% confidence interval: -0.70 to -0.12; P = .0051), which corresponds to a shift from the 50th to the 37th percentile of the outcome distribution. For brain aging, the treatment effect was uncertain. Periodontitis is related to pre-clinical AD in our population.
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
127-141Subventions
Organisme : NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NIH HHS
ID : RF1 AG059421
Pays : United States
Organisme : CIHR
Pays : Canada
Informations de copyright
© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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