Sickle cell nephropathy: insights into the pediatric population.
Children
Kidney disease
Sickle cell disease
Sickle cell nephropathy
Journal
Pediatric nephrology (Berlin, Germany)
ISSN: 1432-198X
Titre abrégé: Pediatr Nephrol
Pays: Germany
ID NLM: 8708728
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
18
12
2020
accepted:
06
05
2021
revised:
10
04
2021
pubmed:
30
5
2021
medline:
9
6
2022
entrez:
29
5
2021
Statut:
ppublish
Résumé
The life expectancy of individuals with sickle cell disease has increased over the years, majorly due to an overall improvement in diagnosis and medical care. Nevertheless, this improved longevity has resulted in an increased prevalence of chronic complications such as sickle cell nephropathy (SCN), which poses a challenge to the medical care of the patient, shortening the lifespan of patients by 20-30 years. Clinical presentation of SCN is age-dependent, with kidney dysfunction slowly beginning to develop from childhood, progressing to chronic kidney disease and kidney failure during the third and fourth decades of life. This review explores the epidemiology, pathology, pathophysiology, clinical presentation, and management of SCN by focusing on the pediatric population. It also discusses the factors that can modify SCN susceptibility.
Identifiants
pubmed: 34050806
doi: 10.1007/s00467-021-05126-4
pii: 10.1007/s00467-021-05126-4
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1231-1243Informations de copyright
© 2021. IPNA.
Références
Ranque B, Menet A, Diop IB, Thiam MM, Diallo D, Diop S, Diagne I, Sanogo I, Kingue S, Chelo D, Wamba G, Diarra M, Anzouan JB, N’Guetta R, Diakite CO, Traore Y, Legueun G, Deme-Ly I, BelingaS Boidy K, Kamara I, Tharaux PL, Jouven X (2014) Early renal damage in patients with sickle cell disease in sub-Saharan Africa: a multinational, prospective, cross-sectional study. Lancet Haematol 1:e64–e73
pubmed: 27030156
doi: 10.1016/S2352-3026(14)00007-6
Piel FB, Patil AP, Howes RE, Nyangiri OA, Gething PW, Dewi M, Temperley WH, Williams TN, Weatherall DJ, Hay SI (2013) Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates. Lancet 381:142–151
pubmed: 23103089
pmcid: 3547249
doi: 10.1016/S0140-6736(12)61229-X
Kato GJ, Piel FB, Reid CD, Gaston MH, Ohene- Frempong K, Krishnamurti L, Smith WR, Panepinto JA, Weatherall DJ, Costa FF, Vichinsky EP (2018) Sickle cell disease. Nat Rev Dis Prim 4:1–22
Taylor C, Kasztan M, Tao B, Pollock JS, Pollock DM (2019) Combined hydroxyurea and ETA receptor blockade reduces renal injury in the humanized sickle cell mouse. Acta Physiol 225:e13178
Vichinsky E (2017) Chronic organ failure in adult sickle cell disease. Hematology 2017:435–439
pubmed: 29222290
pmcid: 6142529
doi: 10.1182/asheducation-2017.1.435
Andong AM, Ngouadjeu EDT, Bekolo CE, Verla VS, Nebongo D, Mboue-Djieka Y, Choukem SP (2017) Chronic complications and quality of life of patients living with sickle cell disease and receiving care in three hospitals in Cameroon: a cross-sectional study. BMC Hematol 17:7
pubmed: 28439419
pmcid: 5399423
doi: 10.1186/s12878-017-0079-7
Sharpe CC, Thein SL (2014) How I treat renal complications in sickle cell disease. Blood 123:3720–3726
pubmed: 24764565
doi: 10.1182/blood-2014-02-557439
Mammen C, Bissonnette ML, Matsell DG (2017) Acute kidney injury in children with sickle cell disease—compounding a chronic problem. Pediatr Nephrol 32:1287–1291
pubmed: 28353009
doi: 10.1007/s00467-017-3650-3
Adewoyin AS (2015) Management of sickle cell disease: a review for physician education in Nigeria (sub-Saharan Africa). Anemia 2015:791498
pubmed: 25667774
pmcid: 4312619
doi: 10.1155/2015/791498
Allison AC (1954) Protection afforded by sickle-cell trait against subtertian malarial infection. Br Med J 1:290–294
pubmed: 13115700
pmcid: 2093356
doi: 10.1136/bmj.1.4857.290
Luzzatto L (2012) Sickle cell anaemia and malaria. Mediterr J Hematol Infect Dis 4:e2012065
pubmed: 23170194
pmcid: 3499995
doi: 10.4084/mjhid.2012.065
Modell B, Darlison M (2008) Global epidemiology of haemoglobin disorders and derived service indicators. Bull World Health Organ 86:480–487
pubmed: 18568278
pmcid: 2647473
doi: 10.2471/BLT.06.036673
Saborio P, Scheinman JI (1999) Sickle cell nephropathy. J Am Soc Nephrol 10:187–192
pubmed: 9890326
doi: 10.1681/ASN.V101187
Olaniran KO, Eneanya D, Nigwekar SU (2019) Sickle cell nephropathy in the pediatric population. Blood Purif 47:205–213
pubmed: 30517931
doi: 10.1159/000494581
Wesson DE (2002) The initiation and progression of sickle cell nephropathy. Kidney Int 61:2277–2286
pubmed: 12028473
doi: 10.1046/j.1523-1755.2002.00363.x
Brewin J, Tewari S, Hannemann A, Al Balushi H, Sharpe C, Gibson JS, Rees DC (2017) Early markers of sickle nephropathy in children with sickle cell anemia are associated with red cell cation transport activity. HemaSphere 1:e2
Zahr RS, Yee ME, Weaver J, Twombley K, Matar RB, Aviles D, Sreedharan R, Rheault MN, Malatesta-Muncher R, Stone H, Srivastava T, Kapur G, Baddi P, Volovelsky O, Pelletier J, Gbadegesin R, Seeherunvong W, Patel HP, Greenbaum LA (2019) Kidney biopsy findings in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study. Pediatr Nephrol 34:1435–1445
pubmed: 30945006
doi: 10.1007/s00467-019-04237-3
Nath KA, Katusic ZS (2012) Vasculature and kidney complications in sickle cell disease. J Am Soc Nephrol 23:781–784
pubmed: 22440903
pmcid: 3338300
doi: 10.1681/ASN.2011101019
Sharpe CC, Thein SL (2011) Sickle cell nephropathy - a practical approach. Br J Haematol 155:287–297
pubmed: 21902687
doi: 10.1111/j.1365-2141.2011.08853.x
Becker AM (2011) Sickle cell nephropathy: challenging the conventional wisdom. Pediatr Nephrol 26:2099–2109
pubmed: 21203778
doi: 10.1007/s00467-010-1736-2
Van Avondt K, Nur E, Zeerleder S (2019) Mechanisms of haemolysis-induced kidney injury. Nat Rev Nephrol 15:671–692
pubmed: 31455889
doi: 10.1038/s41581-019-0181-0
Eshbach ML, Kaur A, Rbaibi Y, Tejero J, Weisz OA (2017) Hemoglobin inhibits albumin uptake by proximal tubule cells: Implications for sickle cell disease. Am J Phys Cell Physiol 312:C733–C740
doi: 10.1152/ajpcell.00021.2017
Rubio-Navarro A, Sanchez-Niño MD, Guerrero-Hue M, García-Caballero C, Gutiérrez E, Yuste C, Sevillano Á, Praga M, Egea J, Román E, Cannata P, Ortega R, Cortegano I, de Andrés B, Gaspar ML, Cadenas S, Ortiz A, Egido J, Moreno JA (2018) Podocytes are new cellular targets of haemoglobin-mediated renal damage. J Pathol 244:296–310
pubmed: 29205354
doi: 10.1002/path.5011
Inusa BPD, Mariachiara L, Giovanni P, Ataga KI (2018) Sickle cell nephropathy: current understanding of the presentation, diagnostic and therapeutic challenges. In: Hematology- Latest Research and Clinical Advances. pp 156–185
Ataga KI, Derebail VK, Caughey M, Elsherif L, Shen JH, Jones SK, Maitra P, Pollock DM, Cai J, Archer DR, Hinderliter AL (2016) Albuminuria is associated with endothelial dysfunction and elevated plasma endothelin-1 in sickle cell anemia. PLoS One 11:e0162652
Saraf SL, Zhang X, Shah B, Kanias T, Gudehithlu KP, Kittles R, Machado RF, Arruda JAL, Gladwin MT, Singh AK, Gordeuk VR (2015) Genetic variants and cell-free hemoglobin processing in sickle cell nephropathy. Haematologica 100:1275–1284
pubmed: 26206798
pmcid: 4591759
doi: 10.3324/haematol.2015.124875
Sundd P, Gladwin MT, Novelli EM (2019) Pathophysiology of sickle cell disease. Annu Rev Pathol Mech Dis 14:263–292
doi: 10.1146/annurev-pathmechdis-012418-012838
Nath KA, Hebbel RP (2015) Sickle cell disease: renal manifestations and mechanisms. Nat Rev Nephrol 11:161–171
pubmed: 25668001
pmcid: 4701210
doi: 10.1038/nrneph.2015.8
Nath KA, Belcher JD, Nath MC, Grande JP, Croatt AJ, Ackerman AW, Katusic ZS, Vercellotti GM (2018) Role of TLR4 signaling in the nephrotoxicity of heme and heme proteins. Am J Physiol Ren Physiol 314:F906–F914
doi: 10.1152/ajprenal.00432.2017
Belcher JD, Chen C, Nguyen J, Milbauer L, Abdulla F, Alayash AI, Smith A, Nath KA, Hebbel RP, Vercellotti GM (2014) Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. Blood 123:377–390
pubmed: 24277079
pmcid: 3894494
doi: 10.1182/blood-2013-04-495887
Ghosh S, Adisa OA, Chappa P, Tan F, Jackson KA, Archer DR, Ofori-Acquah SF (2013) Extracellular hemin crisis triggers acute chest syndrome in sickle mice. J Clin Invest 123:4809–4820
pubmed: 24084741
pmcid: 3809772
doi: 10.1172/JCI64578
Alleyne GA (1975) The kidney in sickle cell anemia. Kidney Int 7:371–379
pubmed: 240053
doi: 10.1038/ki.1975.54
Da Silva Junior GB, Libório AB, De Francesco DE (2011) New insights on pathophysiology, clinical manifestations, diagnosis, and treatment of sickle cell nephropathy. Ann Hematol 90:1371–1379
doi: 10.1007/s00277-011-1327-8
Statius Van Eps LW, Schouten H, Ter Haar Romeny-Wachter CC, La Porte-Wijsman LW (1970) The relation between age and renal concentrating capacity in sickle cell disease and hemoglobin C disease. Clin Chim Acta 27:501–511
pubmed: 5435231
doi: 10.1016/0009-8981(70)90305-0
Scheinman J (1994) Sickle cell nephrology. In: Holliday M, Barratt T, Avner E (eds) Pediatric Nephrology. Williams & Wilkins, Baltimore, pp 908–914
Raj VMS, Freundlich M, Hamideh D, Alvarez O, Seeherunvong W, Abitbol C, Katsoufis C, Chandar J, Ruiz P, Zilleruelo G (2014) Abnormalities in renal tubular phosphate handling in children with sickle cell disease. Pediatr Blood Cancer 61:2267–2270
pubmed: 25132581
doi: 10.1002/pbc.25188
Marsenic O, Couloures KG, Wiley JM (2008) Proteinuria in children with sickle cell disease. Nephrol Dial Transplant 23:715–720
pubmed: 18065783
doi: 10.1093/ndt/gfm858
Feltran LDS, Carvalhaes JTDA, Sesso R (2002) Renal complications of sickle cell disease: managing for optimal outcomes. Pediatr Drugs 4:29–36
doi: 10.2165/00128072-200204010-00004
Hariri E, Mansour A, El Alam A, Daaboul Y, Korjian S, Aoun Bahous S (2018) Sickle cell nephropathy: an update on pathophysiology, diagnosis, and treatment. Int Urol Nephrol 50:1075–1083
pubmed: 29383580
doi: 10.1007/s11255-018-1803-3
Wang WC, Ware RE, Miller ST, Iyer RV, Casella JF, Minniti CP, Rana S, Thornburg CD, Rogers ZR, Kalpatthi RV, Barredo JC, Brown RC, Sarnaik SA, Howard TH, Wynn LW, Kutlar A, Armstrong FD, Files BA, Goldsmith JC, Waclawiw MA, Huang X, Thompson BW (2011) Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG). Lancet 377:1663–1672
pubmed: 21571150
pmcid: 3133619
doi: 10.1016/S0140-6736(11)60355-3
Aloni MN, Ngiyulu RM, Ekulu PM, Mbutiwi FIN, Makulo JR, Gini-Ehungu JL, Nseka NM, Lepira FB (2017) Glomerular hyperfiltration is strongly correlated with age in Congolese children with sickle cell anaemia. Acta Paediatr Int J Paediatr 106:819–824
doi: 10.1111/apa.13784
Aloni MN, Mabidi JLL, Ngiyulu RM, Ekulu PM, Mbutiwi FI, Makulo JR, Sumaili EK, Gini-Ehungu JL, Nsibu CN, Nseka NM, Lepira FB (2017) Prevalence and determinants of microalbuminuria in children suffering from sickle cell anemia in steady state. Clin Kidney J 10:479–486
pubmed: 28852485
pmcid: 5569932
doi: 10.1093/ckj/sfx058
Bernstein J, Whitten C (1960) A histologic appraisal of the kidney in sickle cell anemia. Arch Pathol 70:407–418
pubmed: 13868273
Bhathena DB, Sondheimer JH (1991) The glomerulopathy of homozygous sickle hemoglobin (SS) disease: morphology and pathogenesis. J Am Soc Nephrol 1:1241–1252
pubmed: 1932637
doi: 10.1681/ASN.V1111241
Van Eps LWS, Schouten H, La Porte-Wijsman LW, Struyker Boudier AM (1967) The influence of red blood cell transfusions on the hyposthenuria and renal hemodynamics of sickle cell anemia. Clin Chim Acta 17:449–461
doi: 10.1016/0009-8981(67)90222-7
Dharnidharka VR, Dabbagh S, Atiyeh B, Simpson P, Sarnaik S (1998) Prevalence of microalbuminuria in children with sickle cell disease. Pediatr Nephrol 12:475–478
pubmed: 9745872
doi: 10.1007/s004670050491
Guasch A, Cua M, Mitch WE (1996) Early detection and the course of glomerular injury in patients with sickle cell anemia. Kidney Int 49:786–791
pubmed: 8648921
doi: 10.1038/ki.1996.109
McBurney PG, Hanevold CD, Hernandez CM, Waller JL, McKie KM (2002) Risk factors for microalbuminuria in children with sickle cell anemia. J Pediatr Hematol Oncol 24:473–477
pubmed: 12218596
doi: 10.1097/00043426-200208000-00013
Guasch A, Cua M, You W, Mitch WE (1997) Sickle cell anemia causes a distinct pattern of glomerular dysfunction. Kidney Int 51:826–833
pubmed: 9067917
doi: 10.1038/ki.1997.116
Day TG, Drasar ER, Fulford T, Sharpe CC, Thein SL (2012) Association between hemolysis and albuminuria in adults with sickle cell anemia. Haematologica 97:201–205
pubmed: 21993677
pmcid: 3269478
doi: 10.3324/haematol.2011.050336
Drawz P, Ayyappan S, Nouraie M, Saraf S, Gordeuk V, Hostetter T, Gladwin MT, Little J, (, (2016) Kidney disease among patients with sickle cell disease, hemoglobin SS and SC. Clin J Am Soc Nephrol 11:207–215
pubmed: 26672090
doi: 10.2215/CJN.03940415
Bakir AA, Hathiwala SC, Ainis H, Hryhorczuk DO, Rhee HL, Levy PS, Dunear G (1987) Prognosis of the nephrotic syndrome in sickle glomerulopathy. Am J Nephrol 7:110–115
pubmed: 3605231
doi: 10.1159/000167444
Powars DR, Elliott-Mills DD, Chan L, Niland J, Hiti AL, Opas LM, Johnson C (1991) Chronic renal failure in sickle cell disease: risk factors, clinical course, and mortality. Ann Intern Med 115:614–620
pubmed: 1892333
doi: 10.7326/0003-4819-115-8-614
Bodas P, Huang A, O’Riordan MA, Sedor JR, Dell KM (2013) The prevalence of hypertension and abnormal kidney function in children with sickle cell disease -a cross sectional review. BMC Nephrol 14:2–7
doi: 10.1186/1471-2369-14-237
Powars DR, Chan LS, Hiti A, Ramicone E, Johnson C (2005) Outcome of sickle cell anemia: a 4-decade observational study of 1056 patients. Medicine (Baltimore) 84:363–376
doi: 10.1097/01.md.0000189089.45003.52
Burdmann EA, Jha V (2017) Acute kidney injury due to tropical infectious diseases and animal venoms: a tale of 2 continents. Kidney Int 91:1033–1046
pubmed: 28088326
doi: 10.1016/j.kint.2016.09.051
Van Wolfswinkel ME, Koopmans LC, Hesselink DA, Hoorn EJ, Koelewijn R, Van Hellemond JJ, Van Genderen PJJ (2016) Neutrophil gelatinase-associated lipocalin (NGAL) predicts the occurrence of malaria-induced acute kidney injury. Malar J 15:464
pubmed: 27612570
pmcid: 5017124
doi: 10.1186/s12936-016-1516-y
Amoura A, Moktefi A, Halfon M, Karras A, Rafat C, Gibier JB, Gleeson PJ, Servais A, Argy N, Maillé P, Belenfant X, Gueutin V, Delpierre A, Tricot L, El Karoui K, Jourde-Chiche N, Houze S, Sahali D, Audard V (2020) Malaria, collapsing glomerulopathy, and focal and segmental glomerulosclerosis. Clin J Am Soc Nephrol 15:964–972
pubmed: 32444394
pmcid: 7341769
doi: 10.2215/CJN.00590120
Ouma BJ, Ssenkusu JM, Shabani E, Datta D, Opoka RO, Idro R, Bangirana P, Park G, Joloba ML, Kain KC, John CC, Conroy AL (2020) Endothelial activation, acute kidney injury, and cognitive impairment in pediatric severe malaria. Crit Care Med 48:e734–e743
pubmed: 32618701
pmcid: 7780883
doi: 10.1097/CCM.0000000000004469
Adeloye A, Luzzatto L, Edington GM (1971) Severe malarial infection in a patient with sickle-cell anaemia. Br Med J 2:445–446
pubmed: 5576007
pmcid: 1796190
doi: 10.1136/bmj.2.5759.445
Oniyangi O, Omari AA (2019) Malaria chemoprophylaxis in sickle cell disease. Cochrane Database Syst Rev 2019. https://doi.org/10.1002/14651858.CD003489.pub2
Tewari S, Brousse V, Piel FB, Menzel S, Rees DC (2015) Environmental determinants of severity in sickle cell disease. Haematologica 100:1108–1116
pubmed: 26341524
pmcid: 4800688
doi: 10.3324/haematol.2014.120030
Power-Hays A, Li S, Mensah A, Sobota A (2020) Universal screening for social determinants of health in pediatric sickle cell disease: a quality-improvement initiative. Pediatr Blood Cancer 67:e28006
pubmed: 31571379
World health organisation. Social determinants of health. https://www.who.int/health-topics/socialdeterminants-of-health . Accessed 27 March 2021
Raphael JL (2020) Addressing social determinants of health in sickle cell disease: the role of Medicaid policy. Pediatr Blood Cancer 67:e28202
pubmed: 32037648
doi: 10.1002/pbc.28202
Naik RP, Derebail VK (2017) The spectrum of sickle hemoglobin-related nephropathy: from sickle cell disease to sickle trait. Expert Rev Hematol 10:1087–1094
pubmed: 29048948
pmcid: 5709172
doi: 10.1080/17474086.2017.1395279
Colombatti R, Maschietto N, Varotto E, Grison A, Grazzina N, Meneghello L, Teso S, Carli M, Milanesi O, Sainati L (2010) Pulmonary hypertension in sickle cell disease children under 10 years of age. Br J Haematol 150:601–609
pubmed: 20553267
doi: 10.1111/j.1365-2141.2010.08269.x
Aygun B, Mortier NA, Smeltzer MP, Hankins JS, Ware RE (2011) Glomerular hyperfiltration and albuminuria in children with sickle cell anemia. Pediatr Nephrol 26:1285–1290
pubmed: 21559933
pmcid: 3187922
doi: 10.1007/s00467-011-1857-2
Geard A, Pule GD, Chetcha Chemegni B, Ngo Bitoungui VJ, Kengne AP, Chimusa ER, Wonkam A (2017) Clinical and genetic predictors of renal dysfunctions in sickle cell anaemia in Cameroon. Br J Haematol 178:629–639
pubmed: 28466968
pmcid: 5660286
doi: 10.1111/bjh.14724
Strumph K, Hafeman M, Ranabothu S, Gomes W, Benitez S, Kaskel F, Manwani D, Mahgerefteh J (2021) Nocturnal hypertension associated with stroke and silent cerebral infarcts in children with sickle cell disease. Pediatr Blood Cancer 68:e28883
Moodalbail DG, Falkner B, Keith SW, Mathias RS, Araya CE, Zaritsky JJ, Stuart MJ (2018) Ambulatory hypertension in a pediatric cohort of sickle cell disease. J Am Soc Hypertens 12:542–550
pubmed: 29804939
pmcid: 8563024
doi: 10.1016/j.jash.2018.04.005
Shatat IF, Jakson SM, Blue AE, Johnson MA, Orak JK, Kalpatthi R (2013) Masked hypertension is prevalent in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study. Pediatr Nephrol 28:115–120
pubmed: 22886281
doi: 10.1007/s00467-012-2275-9
Becker AM, Goldberg JH, Henson M, Ahn C, Tong L, Baum M, Buchanan GR (2014) Blood pressure abnormalities in children with sickle cell anemia. Pediatr Blood Cancer 61:518–522
pubmed: 24424792
doi: 10.1002/pbc.24843
Asnani MR, Fraser RA, Reid ME (2011) Higher rates of hemolysis are not associated with albuminuria in Jamaicans with sickle cell disease. PLoS One 6:e18863
pubmed: 21533141
pmcid: 3077410
doi: 10.1371/journal.pone.0018863
Haymann JP, Stankovic K, Levy P, Avellino V, Tharaux PL, Letavernier E, Grateau G, Baud L, Girot R, Lionnet F (2010) Glomerular hyperfiltration in adult sickle cell anemia: a frequent hemolysis associated feature. Clin J Am Soc Nephrol 5:756–761
pubmed: 20185605
pmcid: 2863976
doi: 10.2215/CJN.08511109
Platt OS, Brambilla DJ, Rosse WF, Milner PF, Castro O, Steinberg MH, Klug PP (1994) Mortality in sickle cell disease. Life expectancy and risk factors for early death. N Engl J Med 330:1639–1644
pubmed: 7993409
doi: 10.1056/NEJM199406093302303
Guasch A, Navarrete J, Nass K, Zayas CF (2006) Glomerular involvement in adults with sickle cell hemoglobinopathies: prevalence and clinical correlates of progressive renal failure. J Am Soc Nephrol 17:2228–2235
pubmed: 16837635
doi: 10.1681/ASN.2002010084
Ballas SK (2001) Effect of α-globin genotype on the pathophysiology of sickle cell disease. Pediatr Pathol Mol Med 20:277–286
Steinberg MH, Barton F, Castro O, Pegelow CH, Ballas SK, Kutlar A, Orringer E, Bellevue R, Olivieri N, Eckman J, Varma M, Ramirez G, Adler B, Smith W, Carlos T, Ataga K, DeCastro L, Bigelow C, Saunthararajah Y, Telfer M, Vichinsky E, Claster S, Shurin S, Bridges K, Waclawiw M, Bonds D, Terrin M (2003) Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment. J Am Med Assoc 289:1645–1651
doi: 10.1001/jama.289.13.1645
Toole JFO, Schilling W, Kunze D, Madhavan SM, Konieczkowski M, Gu Y, Luo L, Wu Z, Bruggeman LA, Sedor JR (2018) ApoL1 overexpression drives variant-independent cytotoxicity. J Am Soc Nephrol 29:869–879
doi: 10.1681/ASN.2016121322
Ekulu PM, Nkoy AB, Betukumesu DK, Aloni MN, Makulo JRR, Sumaili EK, Mafuta EM, Elmonem MA, Arcolino FO, Kitetele FN, Lepira FB, van den Heuvel LP, Levtchenko EN (2019) APOL1 risk genotypes are associated with early kidney damage in children in sub-Saharan Africa. Kidney Int Rep 4:930–938
pubmed: 31317115
pmcid: 6612006
doi: 10.1016/j.ekir.2019.04.002
Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI, Bowden DW, Langefeld CD, Oleksyk TK, Uscinski Knob AL, Bernhardy AJ, Hicks PJ, Nelson GW, Vanhollebeke B, Winkler CA, Kopp JB, Pays E, Pollak MR (2010) Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science 329:841–845
pubmed: 20647424
pmcid: 2980843
doi: 10.1126/science.1193032
Kopp JB, Nelson GW, Sampath K, Johnson RC, Genovese G, An P, Friedman D, Briggs W, Dart R, Korbet S, Mokrzycki MH, Kimmel PL, Limou S, Ahuja TS, Berns JS, Fryc J, Simon EE, Smith MC, Trachtman H, Michel DM, Schelling JR, Vlahov D, Pollak M, Winkler CA (2011) APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol 22:2129–2137
pubmed: 21997394
pmcid: 3231787
doi: 10.1681/ASN.2011040388
Ekulu PM, Nkoy AB, Adebayo OC, Kazadi OK, Aloni MN, Arcolino FO, Ngiyulu RM, Gini JLE, Lepira FB, Van den Heuvel LP, Levtchenko EN (2021) A focus on the association of Apol1 with kidney disease in children. Pediatr Nephrol 36:777–788
pubmed: 32253519
doi: 10.1007/s00467-020-04553-z
Kormann R, Jannot AS, Narjoz C, Ribeil JA, Manceau S, Delville M, Joste V, Prié D, Pouchot J, Thervet E, Courbebaisse M, Arlet JB (2017) Roles of APOL1 G1 and G2 variants in sickle cell disease patients: kidney is the main target. Br J Haematol 179:326–335
doi: 10.1111/bjh.14842
Madhavan SM, O’Toole JF, Konieczkowski M, Ganesan S, Bruggeman LA, Sedor JR (2011) APOL1 localization in normal kidney and nondiabetic kidney disease. J Am Soc Nephrol 22:2119–2128
pubmed: 21997392
pmcid: 3231786
doi: 10.1681/ASN.2011010069
Ma L, Shelness GS, Snipes JA, Murea M, Antinozzi PA, Cheng D, Saleem MA, Satchell SC, Banas B, Mathieson PW, Kretzler M, Hemal AK, Rudel LL, Petrovic S, Weckerle A, Pollak MR, Ross MD, Parks JS, Freedman BI (2015) Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines. J Am Soc Nephrol 26:339–348
pubmed: 25012173
doi: 10.1681/ASN.2013091017
Uzureau S, Lecordier L, Uzureau P, Hennig D, Graversen JH, Homblé F, Mfutu PE, Oliveira Arcolino F, Ramos AR, La Rovere RM, Luyten T, Vermeersch M, Tebabi P, Dieu M, Cuypers B, Deborggraeve S, Rabant M, Legendre C, Moestrup SK, Levtchenko E, Bultynck G, Erneux C, Pérez-Morga D, Pays E (2020) APOL1 C-terminal variants may trigger kidney disease through interference with APOL3 control of actomyosin. Cell Rep 30:3821-3836.e13
pubmed: 32187552
pmcid: 7090385
doi: 10.1016/j.celrep.2020.02.064
Lever JM, Boddu R, George JF, Agarwal A (2016) Heme oxygenase-1 in kidney health and disease. Antioxid Redox Signal 25:165–183
pubmed: 26906116
pmcid: 4948210
doi: 10.1089/ars.2016.6659
Anderson S, Meyer TW, Rennke HG, Brenner BM (1985) Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass. J Clin Invest 76:612–619
pubmed: 2993362
pmcid: 423867
doi: 10.1172/JCI112013
Falk RJ, Scheinman J, Phillips G, Orringer E, Johnson A, Jennette JC (1992) Prevalence and pathologic features of sickle cell nephropathy and response to inhibition of angiotensin-converting enzyme. N Engl J Med 326:910–915
pubmed: 1542341
doi: 10.1056/NEJM199204023261402
Fitzhugh CD, Wigfall DR, Ware RE (2005) Enalapril and hydroxyurea therapy for children with sickle nephropathy. Pediatr Blood Cancer 45:982–985
pubmed: 15704213
doi: 10.1002/pbc.20296
Aoki RY, Saad STO (1995) Enalapril reduces the albuminuria of patients with sickle cell disease. Am J Med 98:432–435
pubmed: 7733120
doi: 10.1016/S0002-9343(99)80341-6
McKie KT, Hanevold CD, Hernandez C, Waller JL, Ortiz L, McKie KM (2007) Prevalence, prevention, and treatment of microalbuminuria and proteinuria in children with sickle cell disease. J Pediatr Hematol Oncol 29:140–144
pubmed: 17356390
doi: 10.1097/MPH.0b013e3180335081
Charache S, Terrin ML, Moore RD, Dover GJ, Barton FB, Eckert SV, McMahon RP, Bonds DR (1995) Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. N Engl J Med 332:1317–1322
pubmed: 7715639
doi: 10.1056/NEJM199505183322001
Alvarez O, Montane B, Lopez G, Wilkinson J, Miller T (2006) Early blood transfusions protect against microalbuminuria in children with sickle cell disease. Pediatr Blood Cancer 47:71–76
pubmed: 16261557
doi: 10.1002/pbc.20645
De Jong PE, Van Eps LWS (1985) Sickle cell nephropathy: new insights into its pathophysiology. Kidney Int 27:711–717
pubmed: 3894760
doi: 10.1038/ki.1985.70
Becton LJ, Kalpatthi RV, Rackoff E, Disco D, Orak JK, Jackson SM, Shatat IF (2010) Prevalence and clinical correlates of microalbuminuria in children with sickle cell disease. Pediatr Nephrol 25:1505–1511
pubmed: 20505954
doi: 10.1007/s00467-010-1536-8
Warady BA, Sullivan EK (1998) Renal transplantation in children with sickle cell disease: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). Pediatr Transplant 2:130–133
pubmed: 10082444