The Promise of Tubule Biomarkers in Kidney Disease: A Review.
Acute interstitial nephritis (AIN)
acute tubule necrosis (ATN)
biomarker
epidermal growth factor (EGF)
interleukin 18 (IL-18)
kidney damage
kidney function
kidney injury marker 1 (KIM-1)
monocyte chemoattractant protein 1 (MCP-1)
renal tubule
review
tubular atrophy
tubular disease
tubule dysfunction
tubule injury
tubulointerstitial fibrosis
uromodulin (UMOD)
α1-microglobulin (A1M)
Journal
American journal of kidney diseases : the official journal of the National Kidney Foundation
ISSN: 1523-6838
Titre abrégé: Am J Kidney Dis
Pays: United States
ID NLM: 8110075
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
16
12
2020
accepted:
10
03
2021
pubmed:
30
5
2021
medline:
18
1
2022
entrez:
29
5
2021
Statut:
ppublish
Résumé
For over 70 years, serum creatinine has remained the primary index for detection and monitoring of kidney disease. Tubulointerstitial damage and fibrosis are highly prognostic for subsequent kidney failure in biopsy studies, yet this pathology is invisible to the clinician in the absence of a biopsy. Recent discovery of biomarkers that reflect distinct aspects of kidney tubule disease have led to investigations of whether these markers can provide additional information on risk of chronic kidney disease (CKD) progression and associated adverse clinical end points, above and beyond estimated glomerular filtration rate and albuminuria. These biomarkers can be loosely grouped into those that mark tubule cell injury (eg, kidney injury molecule 1, monocyte chemoattractant protein 1) and those that mark tubule cell dysfunction (eg, α
Identifiants
pubmed: 34051308
pii: S0272-6386(21)00635-1
doi: 10.1053/j.ajkd.2021.03.026
pmc: PMC8545710
mid: NIHMS1709020
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
719-727Subventions
Organisme : NIA NIH HHS
ID : R01 AG034853
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK098234
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK128803
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK102730
Pays : United States
Informations de copyright
Published by Elsevier Inc.
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