Autophagy was activated against the damages of placentas caused by nano-copper oral exposure.
AMP-Activated Protein Kinases
/ metabolism
Animals
Autophagy
/ drug effects
Copper
/ chemistry
Dietary Exposure
/ adverse effects
Female
Inflammation
/ chemically induced
Oxidative Stress
/ drug effects
Phosphatidylinositol 3-Kinases
/ metabolism
Placenta
/ drug effects
Pregnancy
Rats
Rats, Sprague-Dawley
Signal Transduction
/ drug effects
TOR Serine-Threonine Kinases
/ metabolism
Autophagy
Inflammation
Nano-copper
Oxidative stress
PI3K/AKT/AMPK/mTOR
Rat placenta
Journal
Ecotoxicology and environmental safety
ISSN: 1090-2414
Titre abrégé: Ecotoxicol Environ Saf
Pays: Netherlands
ID NLM: 7805381
Informations de publication
Date de publication:
01 Sep 2021
01 Sep 2021
Historique:
received:
01
12
2020
revised:
16
05
2021
accepted:
19
05
2021
pubmed:
30
5
2021
medline:
8
7
2021
entrez:
29
5
2021
Statut:
ppublish
Résumé
Nano-copper (nano-Cu) is widely used in the pharmaceutical field as well as a feed additive for animals owing to its unique physicochemical characteristics and bioactivities. In our previous study, nano-Cu was found to hamper fetal development; however, the toxicity of nano-Cu and its effects in placental function have not been elucidated. Therefore, we investigated the toxic effects of nano-Cu using rat placenta. Pregnant Sprague-Dawley rats were orally exposed to different copper sources from the third day of gestation (GD 3) to GD 18. We found that nano-Cu (180 mg/kg) and CuCl
Identifiants
pubmed: 34051663
pii: S0147-6513(21)00476-0
doi: 10.1016/j.ecoenv.2021.112364
pii:
doi:
Substances chimiques
Copper
789U1901C5
mTOR protein, rat
EC 2.7.1.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
AMP-Activated Protein Kinases
EC 2.7.11.31
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112364Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.