Long-term exposure to particulate matter from air pollution alters airway β-defensin-3 and -4 and cathelicidin host defense peptides production in a murine model.
Antimicrobial peptides
Cathelicidins
Defensins
In vivo
Particulate matter
Journal
Peptides
ISSN: 1873-5169
Titre abrégé: Peptides
Pays: United States
ID NLM: 8008690
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
13
11
2020
revised:
19
05
2021
accepted:
20
05
2021
pubmed:
31
5
2021
medline:
10
2
2022
entrez:
30
5
2021
Statut:
ppublish
Résumé
Epidemiological studies have associated long-term exposure to environmental air pollution particulate matter (PM) with the development of diverse health problems. They include infectious respiratory diseases related to the deregulation of some innate immune response mechanisms, such as the host defense peptides' expression. Herein, we evaluated in BALB/c mice the effect of long-standing exposure (60 days) to urban-PM from the south of Mexico City, with aerodynamic diameters below 2.5 μm (PM
Identifiants
pubmed: 34052349
pii: S0196-9781(21)00089-9
doi: 10.1016/j.peptides.2021.170581
pii:
doi:
Substances chimiques
Air Pollutants
0
Camp protein, mouse
0
Cathelicidins
0
Defb4 protein, mouse
0
IL1B protein, mouse
0
Interleukin-1beta
0
Particulate Matter
0
beta-Defensins
0
beta-defensin 3, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
170581Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.