Hypoxia-induced phenotypic transition from highly invasive to less invasive tumors in glioma stem-like cells: Significance of CD44 and osteopontin as therapeutic targets in glioblastoma.
CD44
Glioblastoma
Glioma stem cell
Hypoxia
Osteopontin
Tumor progression
Journal
Translational oncology
ISSN: 1936-5233
Titre abrégé: Transl Oncol
Pays: United States
ID NLM: 101472619
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
01
03
2021
revised:
10
05
2021
accepted:
21
05
2021
pubmed:
31
5
2021
medline:
31
5
2021
entrez:
30
5
2021
Statut:
ppublish
Résumé
The poor prognosis of glioblastoma multiforme (GBM) is primarily due to highly invasive glioma stem-like cells (GSCs) in tumors. Upon GBM recurrence, GSCs with highly invasive and highly migratory activities must assume a less-motile state and proliferate to regenerate tumor mass. Elucidating the molecular mechanism underlying this transition from a highly invasive phenotype to a less-invasive, proliferative tumor could facilitate the identification of effective molecular targets for treating GBM. Here, we demonstrate that severe hypoxia (1% O
Identifiants
pubmed: 34052625
pii: S1936-5233(21)00129-7
doi: 10.1016/j.tranon.2021.101137
pmc: PMC8175402
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101137Informations de copyright
Copyright © 2021. Published by Elsevier Inc.