Exposure to general anaesthesia in childhood and the subsequent risk of attention-deficit hyperactivity disorder: A meta-analysis of cohort studies.

Anesthesia, General / adverse effects Attention Deficit Disorder with Hyperactivity / epidemiology Cohort Studies Humans
Attention Behaviour Cognitive Surgery

Journal

Asian journal of psychiatry
ISSN: 1876-2026
Titre abrégé: Asian J Psychiatr
Pays: Netherlands
ID NLM: 101517820

Informations de publication

Date de publication:
Aug 2021
Historique:
received: 18 11 2020
revised: 10 05 2021
accepted: 21 05 2021
pubmed: 31 5 2021
medline: 22 7 2021
entrez: 30 5 2021
Statut: ppublish

Résumé

The evidence for a relationship between general anaesthesia induced in childhood and the risk of attention-deficit hyperactivity disorder (ADHD) in later life is inconsistent. We systematically assessed whether such an association existed. We searched the PubMed and EMBASE databases for relevant cohort studies. Relative risks (RRs) and 95 % confidence intervals (CIs) were calculated to determine the relationship between induction of childhood general anaesthesia and the risk of ADHD in later life. Seven studies (eight publications) on developmental outcomes after the induction of childhood general anaesthesia met our inclusion criteria but not our exclusion criteria. Repeat childhood general anaesthesia (RR = 1.84, 95 CI% 1.14-2.97; P < 0.001; I Our meta-analysis indicated that the effect of general anaesthesia on the risk of ADHD is dose- or duration-dependent.

Sections du résumé

BACKGROUND BACKGROUND
The evidence for a relationship between general anaesthesia induced in childhood and the risk of attention-deficit hyperactivity disorder (ADHD) in later life is inconsistent. We systematically assessed whether such an association existed.
METHODS METHODS
We searched the PubMed and EMBASE databases for relevant cohort studies. Relative risks (RRs) and 95 % confidence intervals (CIs) were calculated to determine the relationship between induction of childhood general anaesthesia and the risk of ADHD in later life.
RESULTS RESULTS
Seven studies (eight publications) on developmental outcomes after the induction of childhood general anaesthesia met our inclusion criteria but not our exclusion criteria. Repeat childhood general anaesthesia (RR = 1.84, 95 CI% 1.14-2.97; P < 0.001; I
CONCLUSIONS CONCLUSIONS
Our meta-analysis indicated that the effect of general anaesthesia on the risk of ADHD is dose- or duration-dependent.

Identifiants

DOI: 10.1016/j.ajp.2021.102708 PMID: 34052708
pubmed: 34052708
pii: S1876-2018(21)00164-7
doi: 10.1016/j.ajp.2021.102708
pii:
doi:

Types de publication

Journal Article Meta-Analysis

Langues

eng

Sous-ensembles de citation

IM

Pagination

102708

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Ji-Jun Sun (JJ)

No.3 Psychiatry Department, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. Electronic address: sunjijun7hospital@126.com.

Chun-Yan Zhu (CY)

No.6 Psychiatry Department, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Hai-Yin Jiang (HY)

Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

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Classifications MeSH

questionsmedicales.fr › Anesthésie et analgésie › Anesthésie › Anesthésie générale › Exposure to general anaesthesia in childhood...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles déficitaires de l'attention et du comportement perturbateur › Trouble déficitaire de l'attention avec hyperactivité › Exposure to general anaesthesia in childhood...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Exposure to general anaesthesia in childhood...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Exposure to general anaesthesia in childhood...