A double-blind placebo-controlled trial of minocycline on translocator protein distribution volume in treatment-resistant major depressive disorder.

Depressive Disorder, Major / drug therapy Depressive Disorder, Treatment-Resistant / drug therapy Gyrus Cinguli / diagnostic imaging Humans Minocycline Positron-Emission Tomography Receptors, GABA / metabolism

Journal

Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664

Informations de publication

Date de publication:
29 05 2021
Historique:
received: 06 07 2020
accepted: 30 04 2021
revised: 30 03 2021
entrez: 30 5 2021
pubmed: 31 5 2021
medline: 15 7 2021
Statut: epublish

Résumé

Gliosis is implicated in the pathophysiology of many neuropsychiatric diseases, including treatment-resistant major depressive disorder (TRD). Translocator protein total distribution volume (TSPO V

Identifiants

DOI: 10.1038/s41398-021-01450-3 PMID: 34052828 PMC: PMC8164633
pubmed: 34052828
doi: 10.1038/s41398-021-01450-3
pii: 10.1038/s41398-021-01450-3
pmc: PMC8164633
doi:

Substances chimiques

Receptors, GABA 0
TSPO protein, human 0
Minocycline FYY3R43WGO

Types de publication

Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

334

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Auteurs

Sophia Attwells (S)

Brain Health Imaging Centre and Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.
Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.

Elaine Setiawan (E)

Brain Health Imaging Centre and Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.

Pablo M Rusjan (PM)

Douglas Research Centre, McGill University, 6875 Boulevard Lasalle, Montreal, QC, H4H 1R3, Canada.

Cynthia Xu (C)

Brain Health Imaging Centre and Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.

Stephen J Kish (SJ)

Brain Health Imaging Centre and Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.
Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
Department of Psychiatry, University of Toronto, 250 College Street, Toronto, ON, M5T 1R8, Canada.

Neil Vasdev (N)

Brain Health Imaging Centre and Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.
Department of Psychiatry, University of Toronto, 250 College Street, Toronto, ON, M5T 1R8, Canada.

Sylvain Houle (S)

Brain Health Imaging Centre and Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.
Department of Psychiatry, University of Toronto, 250 College Street, Toronto, ON, M5T 1R8, Canada.

Apitharani Santhirakumar (A)

Brain Health Imaging Centre and Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.

Jeffrey H Meyer (JH)

Brain Health Imaging Centre and Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada. jeffrey.meyer@utoronto.ca.
Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. jeffrey.meyer@utoronto.ca.
Department of Psychiatry, University of Toronto, 250 College Street, Toronto, ON, M5T 1R8, Canada. jeffrey.meyer@utoronto.ca.
ORCID: 0000-0003-4684-5052

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Trouble dépressif majeur › A double-blind placebo-controlled trial of...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Trouble dépressif résistant aux traitements › A double-blind placebo-controlled trial of...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe limbique › Gyrus du cingulum › A double-blind placebo-controlled trial of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A double-blind placebo-controlled trial of...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtacènes › Tétracyclines › Minocycline › A double-blind placebo-controlled trial of...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › A double-blind placebo-controlled trial of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › A double-blind placebo-controlled trial of...