Sodium status is associated with type 2 diabetes mellitus: a systematic review and meta-analysis of observational studies.
Meta-analysis
Observational studies
Sodium
Systematic review
Type 2 diabetes mellitus
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
18
10
2020
accepted:
21
05
2021
pubmed:
31
5
2021
medline:
16
9
2021
entrez:
30
5
2021
Statut:
ppublish
Résumé
The relationship between sodium intake and the risk of developing type 2 diabetes mellitus (T2DM) is inconsistent. We, therefore, aimed to summarize the current evidence by conducting a systematic review and meta-analysis of observational studies. We retrieved studies which compared any marker of sodium status between individuals with T2DM and those without diabetes published in any language by searching online databases from inception up to June 2019. Summary effects were derived using random-effects model. A total of 44 studies with 503,830 participants from 25 countries were included in this study. Sodium status was significantly different between individuals with and without T2DM (Hedges' g = 0.21; 95% CI 0.02, 0.40; P = 0.029). Individuals with T2DM had higher sodium intake compared to non-diabetic controls (WMD = 621.79 mg/day; 95% CI 321.53, 922.06; P < 0.001) and 24-h urinary excretion was associated with likelihood of developing T2DM (OR = 1.27, 95% CI 1.15, 1.41; P < 0.001). Furthermore, salivary, hair, and platelet sodium were higher in patients with T2DM compared to controls (P < 0.05). The findings of the current meta-analysis suggest that sodium levels are higher in patients with T2DM compared to non-diabetic controls; however, given that these studies are observational, it is not possible to infer causality.
Identifiants
pubmed: 34052916
doi: 10.1007/s00394-021-02595-z
pii: 10.1007/s00394-021-02595-z
doi:
Substances chimiques
Biomarkers
0
Sodium
9NEZ333N27
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3543-3565Informations de copyright
© 2021. Springer-Verlag GmbH Germany, part of Springer Nature.
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