Atherothrombosis model by silencing of protein C in APOE*3-Leiden.CETP transgenic mice.
Apolipoprotein E3
Atherosclerosis
Mice
Protein C
Thrombosis
Journal
Journal of thrombosis and thrombolysis
ISSN: 1573-742X
Titre abrégé: J Thromb Thrombolysis
Pays: Netherlands
ID NLM: 9502018
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
accepted:
18
05
2021
pubmed:
31
5
2021
medline:
1
3
2022
entrez:
30
5
2021
Statut:
ppublish
Résumé
Murine atherosclerosis models are key for investigation of atherosclerosis pathophysiology and drug development. However, they do not feature spontaneous atherothrombosis as a final stage of atherosclerosis. Transgenic mice expressing both the human mutant apolipoprotein E form APOE*3-Leiden and human cholesteryl ester transfer protein (CETP), i.e. APOE*3-Leiden.CETP mice, feature a moderate hyperlipoproteinemia and atherosclerosis phenotype. In contrast to apolipoprotein E deficient (Apoe-
Identifiants
pubmed: 34052976
doi: 10.1007/s11239-021-02488-2
pii: 10.1007/s11239-021-02488-2
pmc: PMC8568858
doi:
Substances chimiques
Apolipoproteins E
0
Cholesterol Ester Transfer Proteins
0
Lipids
0
Pharmaceutical Preparations
0
Protein C
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
715-719Subventions
Organisme : Trombosestichting Nederland
ID : 2018-1
Informations de copyright
© 2021. The Author(s).
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