Pathophysiology of Spinal Cord Injury.

Humans Spinal Cord Spinal Cord Injuries
Neural circuits Pathogenesis Plasticity Secondary injury Spinal cord injury

Journal

Neurosurgery clinics of North America
ISSN: 1558-1349
Titre abrégé: Neurosurg Clin N Am
Pays: United States
ID NLM: 9008004

Informations de publication

Date de publication:
Jul 2021
Historique:
entrez: 31 5 2021
pubmed: 1 6 2021
medline: 29 10 2021
Statut: ppublish

Résumé

Spinal cord injury (SCI) triggers a complex cascade of molecular and cellular events that leads to progressive cell loss and tissue damage. In this review, the authors outline the temporal profile of SCI pathogenesis, focusing on key mediators of the secondary injury, and highlight cutting edge insights on the alterations in neural circuits that largely define the chronic injury environment. They bridge these important basic science concepts with clinical implications for informing novel experimental therapies. Furthermore, emerging concepts in the study of SCI pathogenesis that are transforming fundamental research into innovative clinical treatment paradigms are outlined.

Identifiants

DOI: 10.1016/j.nec.2021.03.002 PMID: 34053718
pubmed: 34053718
pii: S1042-3680(21)00023-1
doi: 10.1016/j.nec.2021.03.002
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

305-313

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Laureen D Hachem (LD)

Division of Neurosurgery, Department of Surgery, University of Toronto, 149 College Street, Toronto, Ontario M5T 1P5, Canada; Division of Neurosurgery, Toronto Western Hospital, University Health Network, 399 Bathurst Street, Suite 4W-449, Toronto, Ontario M5T 2S8, Canada.

Michael G Fehlings (MG)

Division of Neurosurgery, Department of Surgery, University of Toronto, 149 College Street, Toronto, Ontario M5T 1P5, Canada; Division of Neurosurgery, Toronto Western Hospital, University Health Network, 399 Bathurst Street, Suite 4W-449, Toronto, Ontario M5T 2S8, Canada. Electronic address: Michael.Fehlings@uhn.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pathophysiology of Spinal Cord Injury.
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Pathophysiology of Spinal Cord Injury.
questionsmedicales.fr › Plaies et blessures › Traumatismes de la moelle épinière › Pathophysiology of Spinal Cord Injury.