Statins Improve Clinical Outcome After Non-aneurysmal Subarachnoid Hemorrhage: A Translational Insight From a Systematic Review of Experimental Studies.
non-aneurysmal SAH
recovery
regenerative medicine
statin treatment
stroke
translational study
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
10
2020
accepted:
17
03
2021
entrez:
31
5
2021
pubmed:
1
6
2021
medline:
1
6
2021
Statut:
epublish
Résumé
The efficacy of statin-treatment in aneurysmal subarachnoid hemorrhage (SAH) remains controversial. We aimed to investigate the effects of statin-treatment in non-aneurysmal (na)SAH in accordance with animal research data illustrating the pathophysiology of naSAH. We systematically searched PubMed using PRISMA-guidelines and selected experimental studies assessing the statin-effect on SAH. Detecting the accordance of the applied experimental models with the pathophysiology of naSAH, we analyzed our institutional database of naSAH patients between 1999 and 2018, regarding the effect of statin treatment in these patients and creating a translational concept. Patient characteristics such as statin-treatment (simvastatin 40 mg/d), the occurrence of cerebral vasospasm (CVS), delayed infarction (DI), delayed cerebral ischemia (DCI), and clinical outcome were recorded. In our systematic review of experimental studies, we found 13 studies among 18 titles using blood-injection-animal-models to assess the statin-effect in accordance with the pathophysiology of naSAH. All selected studies differ on study-setting concerning drug-administration, evaluation methods, and neurological tests. Patients from the Back to Bedside project, including 293 naSAH-patients and 51 patients with simvastatin-treatment, were recruited for this analysis. Patients under treatment were affected by a significantly lower risk of CVS (
Identifiants
pubmed: 34054685
doi: 10.3389/fneur.2021.620096
pmc: PMC8160298
doi:
Types de publication
Systematic Review
Langues
eng
Pagination
620096Informations de copyright
Copyright © 2021 Kashefiolasl, Wagner, Brawanski, Seifert, Wanderer, Andereggen and Konczalla.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Nat Rev Neurol. 2014 Jan;10(1):44-58
pubmed: 24323051
Brain. 2001 Feb;124(Pt 2):249-78
pubmed: 11157554
Stroke. 2008 Oct;39(10):2891-3
pubmed: 18658043
Stroke. 2015 Feb;46(2):382-8
pubmed: 25516195
Stroke. 2005 Aug;36(8):1627-32
pubmed: 16049199
Neurocrit Care. 2010 Apr;12(2):285-96
pubmed: 19921470
Turk Neurosurg. 2016;26(4):538-44
pubmed: 27400100
Neurocrit Care. 2011 Sep;15(2):298-301
pubmed: 21826581
J Neurol Sci. 2012 Aug 15;319(1-2):117-23
pubmed: 22658532
Stroke. 2008 Sep;39(9):2622-6
pubmed: 18658040
Acta Neurochir (Wien). 2015 Jun;157(6):1031-41; discussion 1041
pubmed: 25894080
PLoS One. 2011 Feb 23;6(2):e17062
pubmed: 21373645
Int J Mol Med. 2016 Apr;37(4):1059-66
pubmed: 26935263
Stroke. 2005 Sep;36(9):2024-6
pubmed: 16051891
Neurology. 1986 Mar;36(3):329-33
pubmed: 3951698
Neurosurgery. 2006 May;58(5):945-51; discussion 945-51
pubmed: 16639331
Sci Rep. 2014 Apr 25;4:4573
pubmed: 24763190
Stroke. 2002 Dec;33(12):2950-6
pubmed: 12468796
Ann Clin Lab Sci. 2010 Winter;40(1):32-42
pubmed: 20124328
J Neurosurg Anesthesiol. 2009 Oct;21(4):326-33
pubmed: 19955895
Stroke. 2010 Jan;41(1):e47-52
pubmed: 19875741
Neurosurg Focus. 2006 Sep 15;21(3):E11
pubmed: 17029335
J Neurotrauma. 2011 Dec;28(12):2493-501
pubmed: 21787168
Lancet Neurol. 2014 Jul;13(7):666-75
pubmed: 24837690
Acta Neurochir (Wien). 2010 Aug;152(8):1399-406; discussion 1405-6
pubmed: 20440630
Am J Vet Res. 2013 Aug;74(8):1111-7
pubmed: 23879849
J Neurosci Res. 2008 Dec;86(16):3635-43
pubmed: 18683242
Transl Stroke Res. 2013 Jun;4(3):368-74
pubmed: 23658597
Mol Med Rep. 2018 Jan;17(1):1651-1659
pubmed: 29257200
J Neurointerv Surg. 2016 Dec;8(12):1247-1252
pubmed: 26847333
J Cereb Blood Flow Metab. 2009 Aug;29(8):1444-53
pubmed: 19458605
Int J Clin Exp Med. 2015 May 15;8(5):7198-208
pubmed: 26221259