Progesterone Dampens Immune Responses in

Adult Autoimmune Diseases / immunology CD4-Positive T-Lymphocytes / drug effects Cells, Cultured Female Gene Expression Regulation / drug effects Humans Lymphocyte Activation / drug effects Pregnancy Pregnancy Complications / immunology Progesterone / pharmacology
CD4+ T cells T cell activation progesterone protein profiling transcriptomics

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2021
Historique:
received: 25 02 2021
accepted: 26 04 2021
entrez: 31 5 2021
pubmed: 1 6 2021
medline: 21 10 2021
Statut: epublish

Résumé

The changes in progesterone (P4) levels during and after pregnancy coincide with the temporary improvement and worsening of several autoimmune diseases like multiple sclerosis (MS) and rheumatoid arthritis (RA). Most likely immune-endocrine interactions play a major role in these pregnancy-induced effects. In this study, we used next generation sequencing to investigate the direct effects of P4 on CD4

Identifiants

DOI: 10.3389/fimmu.2021.672168 PMID: 34054852 PMC: PMC8149943
pubmed: 34054852
doi: 10.3389/fimmu.2021.672168
pmc: PMC8149943
doi:

Substances chimiques

Progesterone 4G7DS2Q64Y

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

672168

Informations de copyright

Copyright © 2021 Hellberg, Raffetseder, Rundquist, Magnusson, Papapavlou, Jenmalm, Ernerudh and Gustafsson.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Sandra Hellberg (S)

Bioinformatics, Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden.
Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Johanna Raffetseder (J)

Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Olof Rundquist (O)

Bioinformatics, Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden.

Rasmus Magnusson (R)

Bioinformatics, Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden.

Georgia Papapavlou (G)

Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Maria C Jenmalm (MC)

Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Jan Ernerudh (J)

Department of Clinical Immunology and Transfusion Medicine and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Mika Gustafsson (M)

Bioinformatics, Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Progesterone Dampens Immune Responses in
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Progesterone Dampens Immune Responses in
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Progesterone Dampens Immune Responses in
questionsmedicales.fr › Cellules › Cellules cultivées › Progesterone Dampens Immune Responses in
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Progesterone Dampens Immune Responses in
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Progesterone Dampens Immune Responses in
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Progesterone Dampens Immune Responses in
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Progesterone Dampens Immune Responses in
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Progesterone Dampens Immune Responses in
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la progestérone › Progestérone › Progesterone Dampens Immune Responses in