Changes in Circadian Rhythms Dysregulate Inflammation in Ageing: Focus on Leukocyte Trafficking.
chronotherapy
circadian rhythm
inflammation
leukocytes
trafficking
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
02
2021
accepted:
13
04
2021
entrez:
31
5
2021
pubmed:
1
6
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Leukocyte trafficking shows strong diurnal rhythmicity and is tightly regulated by circadian rhythms. As we age, leukocyte trafficking becomes dysregulated, contributing to the increased systemic, low-grade, chronic inflammation observed in older adults. Ageing is also associated with diminished circadian outputs and a dysregulation of the circadian rhythm. Despite this, there is little evidence to show the direct impact of age-associated dampening of circadian rhythms on the dysregulation of leukocyte trafficking. Here, we review the core mammalian circadian clock machinery and discuss the changes that occur in this biological system in ageing. In particular, we focus on the changes that occur to leukocyte trafficking rhythmicity with increasing age and consider how this impacts inflammation and the development of immune-mediated inflammatory disorders (IMIDs). We aim to encourage future ageing biology research to include a circadian approach in order to fully elucidate whether age-related circadian changes occur as a by-product of healthy ageing, or if they play a significant role in the development of IMIDs.
Identifiants
pubmed: 34054857
doi: 10.3389/fimmu.2021.673405
pmc: PMC8160305
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
673405Subventions
Organisme : Wellcome Trust
ID : 108871/Z/15/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 107851/Z/15/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P023576/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P023576/2
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/20/2/34799
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S002715/1
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Nathan, Gibbs, Rainger and Chimen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Genes Dev. 2006 Jul 15;20(14):1868-73
pubmed: 16847346
Sci Rep. 2020 Feb 13;10(1):2569
pubmed: 32054990
Front Physiol. 2018 Feb 20;9:113
pubmed: 29515456
Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):582-7
pubmed: 22184247
Brain Res Rev. 2006 Jun;51(1):1-60
pubmed: 16337005
Nat Med. 2014 Aug;20(8):919-26
pubmed: 25064128
Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21407-12
pubmed: 19955445
J Biol Rhythms. 1998 Oct;13(5):430-6
pubmed: 9783234
J Clin Invest. 2011 Jun;121(6):2133-41
pubmed: 21633182
J Neurosci. 2011 Jul 13;31(28):10201-5
pubmed: 21752996
Science. 2000 Apr 28;288(5466):682-5
pubmed: 10784453
Sci Rep. 2018 Jun 29;8(1):9825
pubmed: 29959387
Nat Rev Neurosci. 2018 Aug;19(8):453-469
pubmed: 29934559
Annu Rev Physiol. 2010;72:551-77
pubmed: 20148688
J Clin Invest. 2020 Oct 1;130(10):5603-5617
pubmed: 32692732
J Clin Endocrinol Metab. 1946 Apr;6:287-94
pubmed: 21025121
Cell. 2013 May 23;153(5):1025-35
pubmed: 23706740
Trends Immunol. 2019 Jun;40(6):524-537
pubmed: 31109762
Neuron. 1995 Apr;14(4):697-706
pubmed: 7718233
J Neurosci. 2006 Aug 30;26(35):9047-56
pubmed: 16943563
Immunity. 2018 Dec 18;49(6):1175-1190.e7
pubmed: 30527911
Ageing Res Rev. 2007 May;6(1):12-27
pubmed: 17369106
J Immunol. 2016 Mar 15;196(6):2466-75
pubmed: 26873990
Curr Biol. 2006 Nov 7;16(21):R914-6
pubmed: 17084685
FASEB J. 2016 Nov;30(11):3759-3770
pubmed: 27488122
Front Immunol. 2017 May 09;8:516
pubmed: 28536575
Science. 2013 Sep 27;341(6153):1483-8
pubmed: 23970558
Nat Commun. 2018 Oct 12;9(1):4246
pubmed: 30315268
Int J Mol Sci. 2020 Apr 02;21(7):
pubmed: 32252431
Hum Vaccin Immunother. 2013 Jun;9(6):1364-7
pubmed: 23584248
Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12843-8
pubmed: 17646651
J Exp Med. 2016 Nov 14;213(12):2567-2574
pubmed: 27799619
Trends Endocrinol Metab. 2016 Apr;27(4):192-203
pubmed: 26947521
Biochem Biophys Res Commun. 2018 Jan 8;495(2):1675-1680
pubmed: 29217191
PLoS Biol. 2014 Apr 15;12(4):e1001839
pubmed: 24736997
Annu Rev Neurosci. 2012;35:445-62
pubmed: 22483041
Immunity. 2017 Jan 17;46(1):120-132
pubmed: 28087238
J Mol Biol. 2020 May 29;432(12):3700-3713
pubmed: 31931006
Immunol Cell Biol. 2018 Sep;96(8):831-840
pubmed: 29603362
J Biol Rhythms. 2008 Apr;23(2):150-9
pubmed: 18375864
Front Immunol. 2020 Apr 03;11:576
pubmed: 32346378
Immunity. 2019 Feb 19;50(2):390-402.e10
pubmed: 30709741
Nature. 2008 Mar 27;452(7186):442-7
pubmed: 18256599
Exp Gerontol. 2002 Jan-Mar;37(2-3):427-39
pubmed: 11772530
Pharmacol Res. 2021 Jan;163:105323
pubmed: 33276099
J Biol Rhythms. 2005 Oct;20(5):391-403
pubmed: 16267379
Nat Rev Endocrinol. 2018 Oct;14(10):576-590
pubmed: 30046148
Immunity. 2014 Nov 20;41(5):694-707
pubmed: 25517612
Trends Immunol. 2019 Feb;40(2):113-127
pubmed: 30626541
Immunity. 2012 Aug 24;37(2):290-301
pubmed: 22863835
J Clin Invest. 2017 Feb 1;127(2):437-446
pubmed: 28145903
Cell Death Dis. 2020 Feb 18;11(2):129
pubmed: 32071294
Front Immunol. 2020 Feb 14;11:102
pubmed: 32117256
Nat Rev Immunol. 2013 Mar;13(3):190-8
pubmed: 23391992
Blood. 2009 May 21;113(21):5134-43
pubmed: 19293427
Aging (Albany NY). 2010 Dec;2(12):936-44
pubmed: 21149897
Elife. 2020 May 12;9:
pubmed: 32396064