Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice.
C3 glomerulonephritis
C3 glomerulonephritis mouse model
Pichia pastoris
chaperonin
complement system
factor H
protein disulfide isomerase (PDI)
therapeutic protein
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
15
03
2021
accepted:
22
04
2021
entrez:
31
5
2021
pubmed:
1
6
2021
medline:
27
10
2021
Statut:
epublish
Résumé
Recombinant human factor H (hFH) has potential for treating diseases linked to aberrant complement regulation including C3 glomerulopathy (C3G) and dry age-related macular degeneration. Murine FH (mFH), produced in the same host, is useful for pre-clinical investigations in mouse models of disease. An abundance of FH in plasma suggests high doses, and hence microbial production, will be needed. Previously,
Identifiants
pubmed: 34054871
doi: 10.3389/fimmu.2021.681098
pmc: PMC8149785
doi:
Substances chimiques
Complement C3
0
Recombinant Proteins
0
Complement Factor H
80295-65-4
Protein Disulfide-Isomerases
EC 5.3.4.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
681098Subventions
Organisme : Medical Research Council
ID : MR/S025502/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT085226
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 212252/Z/18/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1001971
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Kerr, Herbert, Makou, Abramczyk, Malik, Lomax-Browne, Yang, Pappworth, Denton, Richards, Marchbank, Pickering and Barlow.
Déclaration de conflit d'intérêts
KM has received consultancy or research income from Gemini Therapeutics Inc, Freeline Therapeutics, MPM Capital, Idorsia Pharmaceuticals Ltd and Catalyst Biosciences. PB is a scientific co-founder of, and has received consultancy and research income from, Gemini Therapeutics Inc. AH is founder and Chief Scientific Officer of Invizius. EM is currently an employee of Invizius. AR has been employed at GlaxoSmithKline since October 2014. Results reported in this work were undertaken during her Wellcome Trust Intermediate Clinical Fellowship. Her spouse, David Kavanagh, is head of the National Renal Complement Therapeutics Centre, UK, and a board member and scientific advisor to Gyroscope Therapeutics Ltd. PNB and AR are co-authors on a recombinant CFH patent application (EP10803266A). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Semin Immunopathol. 2018 Jan;40(1):49-64
pubmed: 29327071
Appl Microbiol Biotechnol. 2012 Nov;96(3):763-72
pubmed: 22885695
Glycobiology. 2007 Sep;17(9):932-44
pubmed: 17591618
Microb Cell Fact. 2006 Dec 14;5:39
pubmed: 17169150
Pediatr Nephrol. 2008 Aug;23(8):1363-6
pubmed: 18425537
Mol Immunol. 2009 Jun;46(10):1942-50
pubmed: 19411110
Pediatr Nephrol. 2006 Nov;21(11):1769-71
pubmed: 16909242
Appl Biochem Biotechnol. 2011 Aug;164(7):1037-47
pubmed: 21340538
J Am Soc Nephrol. 2017 May;28(5):1462-1474
pubmed: 27932477
Biochemistry. 2013 Jun 11;52(23):3949-62
pubmed: 23701234
Mol Immunol. 2017 Apr;84:65-76
pubmed: 27939104
Nephrol Dial Transplant. 2017 Mar 1;32(3):459-465
pubmed: 27507892
J Ind Microbiol Biotechnol. 2019 Jul;46(7):887-898
pubmed: 30879221
Immunobiology. 2012 Feb;217(2):281-97
pubmed: 22137027
Gene. 1994 Jun 10;143(2):301-2
pubmed: 8206393
Immunol Rev. 2016 Nov;274(1):33-58
pubmed: 27782325
Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3040-9
pubmed: 25991857
Appl Microbiol Biotechnol. 2016 Jun;100(12):5453-65
pubmed: 26883349
Eur J Intern Med. 2020 Mar;73:51-58
pubmed: 31791575
Appl Microbiol Biotechnol. 2007 Feb;74(2):381-9
pubmed: 17051412
Immunobiology. 2019 Jul;224(4):511-517
pubmed: 31109748
Immunobiology. 2018 Aug - Sep;223(8-9):519-523
pubmed: 29525356
Nat Genet. 2011 Oct 23;43(12):1232-6
pubmed: 22019782
J Immunol. 1984 Dec;133(6):3250-4
pubmed: 6238095
Nat Rev Nephrol. 2018 Jan;14(1):26-47
pubmed: 29199277
Mol Immunol. 2010 Aug;47(13):2187-97
pubmed: 20580090
J Immunol. 2008 Aug 15;181(4):2610-9
pubmed: 18684951
J Biol Chem. 2005 Jan 28;280(4):2569-78
pubmed: 15536079
Appl Microbiol Biotechnol. 2011 Feb;89(4):1127-35
pubmed: 20981418
Food Chem. 2017 Dec 15;237:825-832
pubmed: 28764073
Science. 2006 Sep 8;313(5792):1441-3
pubmed: 16960007
Kidney Int. 2016 Jul;90(1):109-22
pubmed: 27165610
Hum Mol Genet. 2015 Jul 1;24(13):3861-70
pubmed: 25788521
J Exp Med. 2007 Jun 11;204(6):1249-56
pubmed: 17517971
Immunol Rev. 2001 Apr;180:146-61
pubmed: 11414356
JAMA Ophthalmol. 2018 Jun 1;136(6):666-677
pubmed: 29801123
Protein Expr Purif. 2011 Apr;76(2):254-63
pubmed: 21146613
Curr Opin Biotechnol. 1999 Oct;10(5):422-7
pubmed: 10508632
J Immunol. 2013 Jul 15;191(2):912-21
pubmed: 23772024
Front Chem. 2014 Aug 26;2:70
pubmed: 25207270
Blood. 2017 Mar 2;129(9):1184-1196
pubmed: 28057640
Lancet. 2012 May 5;379(9827):1728-38
pubmed: 22559899
Int J Pharm. 1999 Nov 30;191(2):141-9
pubmed: 10564840
Semin Cell Dev Biol. 2019 Jan;85:122-131
pubmed: 29305301
Kidney Int. 2016 Mar;89(3):701-11
pubmed: 26880462
Curr Opin Investig Drugs. 2002 Jul;3(7):1017-23
pubmed: 12186261
Mol Immunol. 2018 Oct;102:89-119
pubmed: 30121124
J Biol Chem. 2017 Aug 11;292(32):13345-13360
pubmed: 28637873
Cell. 2001 Dec 28;107(7):827-30
pubmed: 11779459
Pediatr Nephrol. 2001 Jul;16(7):554-6
pubmed: 11465803
Biochim Biophys Acta. 2004 Jun 1;1699(1-2):35-44
pubmed: 15158710
Clin Exp Immunol. 2008 Jan;151(1):1-13
pubmed: 18081690
J Immunol. 2015 Nov 15;195(10):4986-98
pubmed: 26459349
J Immunol. 2013 Jun 1;190(11):5712-21
pubmed: 23616575
Mol Immunol. 2015 Sep;67(1):43-50
pubmed: 25804937
BMC Nephrol. 2018 Jan 12;19(1):7
pubmed: 29329521
Am J Kidney Dis. 2005 Feb;45(2):415-21
pubmed: 15685522
Am J Pathol. 2015 Jan;185(1):29-42
pubmed: 25447048
Nat Genet. 2002 Aug;31(4):424-8
pubmed: 12091909
Appl Biochem Biotechnol. 2014 Mar;172(5):2400-11
pubmed: 24390856
Ophthalmology. 2020 Feb;127(2):186-195
pubmed: 31474439
Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3703-3711
pubmed: 30808757
Kidney Int. 2018 Feb;93(2):470-481
pubmed: 28941939
Prog Retin Eye Res. 2018 Jan;62:38-57
pubmed: 28928087
Kidney Int. 2010 Aug;78(3):279-86
pubmed: 20445496
Mol Immunol. 2017 Apr;84:84-106
pubmed: 28216098
Nat Biotechnol. 2007 Nov;25(11):1256-64
pubmed: 17989688
Nat Cell Biol. 2015 Jul;17(7):829-38
pubmed: 26123108
J Immunol Methods. 1990 Sep 14;132(2):191-5
pubmed: 2170533
J Biotechnol. 2006 Feb 24;121(4):458-70
pubmed: 16274825
Am J Hum Genet. 2002 Dec;71(6):1285-95
pubmed: 12424708
Ophthalmic Surg Lasers Imaging Retina. 2015 Apr;46(4):413-22
pubmed: 25970861
J Am Soc Nephrol. 2018 Jun;29(6):1649-1661
pubmed: 29588430
Lancet Glob Health. 2014 Feb;2(2):e106-16
pubmed: 25104651
Biotechnology (N Y). 1993 Aug;11(8):905-10
pubmed: 7763913
Front Immunol. 2019 Jul 11;10:1607
pubmed: 31354740
Kidney Int. 2015 Dec;88(6):1314-1322
pubmed: 26221753
Adv Immunol. 2009;104:115-49
pubmed: 20457117
Plant Biotechnol J. 2011 Apr;9(3):373-83
pubmed: 20723134
Biochem Biophys Res Commun. 2010 Nov 19;402(3):519-24
pubmed: 20971072
Ann Med. 2006;38(7):450-71
pubmed: 17101537
J Immunol. 2018 Jan 1;200(1):316-326
pubmed: 29187587
J Immunol. 2006 Nov 1;177(9):6308-16
pubmed: 17056561
Food Chem. 2018 May 15;248:340-345
pubmed: 29329863
3 Biotech. 2019 Feb;9(2):62
pubmed: 30729086
Front Immunol. 2019 May 15;10:1007
pubmed: 31156618
Nat Immunol. 2010 Sep;11(9):785-97
pubmed: 20720586
Pediatr Nephrol. 2010 Dec;25(12):2431-42
pubmed: 20526633
J Mol Recognit. 2005 Mar-Apr;18(2):119-38
pubmed: 15565717
Semin Thromb Hemost. 2014 Jun;40(4):465-71
pubmed: 24799308