Cell fusion in cancer hallmarks: Current research status and future indications.
cancer therapy
cell fusion
cell fusion in cancer
fusogens
hybrid cells
Journal
Oncology letters
ISSN: 1792-1074
Titre abrégé: Oncol Lett
Pays: Greece
ID NLM: 101531236
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
05
12
2020
accepted:
09
04
2021
entrez:
31
5
2021
pubmed:
1
6
2021
medline:
1
6
2021
Statut:
ppublish
Résumé
Cell fusion is involved in several physiological processes, such as reproduction, development and immunity. Although cell fusion in tumors was reported 130 years ago, it has recently attracted great interest, with recent progress in tumorigenesis research. However, the role of cell fusion in tumor progression remains unclear. The pattern of cell fusion and its role under physiological conditions are the basis for our understanding of the pathological role of cell fusion. However, the role of cell fusion in tumors and its functions are complicated. Cell fusion can directly increase tumor heterogeneity by forming polyploids or aneuploidies. Several studies have reported that cell fusion is associated with tumorigenesis, metastasis, recurrence, drug resistance and the formation of cancer stem cells. Given the diverse roles cell fusion plays in different tumor phenotypes, methods based on targeted cell fusion have been designed to treat tumors. Research on cell fusion in tumors may provide novel ideas for further treatment.
Identifiants
pubmed: 34055095
doi: 10.3892/ol.2021.12791
pii: OL-0-0-12791
pmc: PMC8138896
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
530Informations de copyright
Copyright: © Wang et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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