The 6-week Effects of HIIT on Biomarkers of Tissue and Oxidative Damage in Wistar Rats Previously Supplemented with Pyridoxine.
HIIT
Pyridoxine
antioxidant
oxidative stress
Journal
International journal of exercise science
ISSN: 1939-795X
Titre abrégé: Int J Exerc Sci
Pays: United States
ID NLM: 101513127
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
31
5
2021
pubmed:
1
6
2021
medline:
1
6
2021
Statut:
epublish
Résumé
We aimed to analyze the effects of long high-intensity interval training (HIIT) associated with pyridoxin supplementation on tissue and oxidative injury markers in animals. Male Wistar rats were divided into three groups (n = 8): sedentary (GS), HIIT (GH), and HIIT + pyridoxine (GHP). The HIIT comprised 18 sessions of 7 repetitions of 2min × 2min rest, 3 times per week. Pyridoxine was administered to the GHP group 1h before the exercise. The Thiobarbituric acid reactive substances (TBARS) and sulfhydryl group (SH) were analyzed as markers of oxidative stress and CK, LDH, ALT and AST as tissue lesions. There was an increase in the correlation between CK and LDH of 172.86% and 268.83% in the GH group compared with the GS group, respectively. There was a reduction in CK (34.37%) and LDH (34.74%) compared with the GH group, which had an increase of 229.03% in ALT. Pyridoxine supplementation reduced ALT by 80.62% in the GHP group compared with no-supplementation GH group. In addition, there was a reduction in plasma MDA (52.92%), liver (20.30%) and cardiac (22.06%) tissues in GHP compared to GH. It was possible to conclude that administration of pyridoxine attenuated oxidative stress, and tissue injuries induced by HIIT.
Types de publication
Journal Article
Langues
eng
Pagination
36-381Références
J Hum Kinet. 2017 Mar 15;56:139-148
pubmed: 28469752
J Sports Med Phys Fitness. 2016 May;56(5):606-15
pubmed: 27285349
Int J Environ Res Public Health. 2019 Oct 31;16(21):
pubmed: 31683746
Biomed Environ Sci. 2020 Aug 20;33(8):603-613
pubmed: 32933612
Scand J Med Sci Sports. 2012 Dec;22(6):764-75
pubmed: 21507065
J Int Soc Sports Nutr. 2014 Dec 24;11(1):58
pubmed: 25649187
Sports Med. 2020 Jan;50(1):25-53
pubmed: 31531769
Nutrients. 2014 Dec 12;6(12):5819-38
pubmed: 25514562
Free Radic Biol Med. 2001 Aug 1;31(3):331-5
pubmed: 11461770
Jpn J Physiol. 2004 Feb;54(1):47-52
pubmed: 15040848
Life Sci. 2015 Oct 15;139:75-82
pubmed: 26285177
Free Radic Biol Med. 2011 Sep 1;51(5):942-50
pubmed: 21167935
Med Sci Sports Exerc. 1999 Mar;31(3):400-8
pubmed: 10188744
Food Chem Toxicol. 2018 Apr;114:11-22
pubmed: 29438775
Eur J Med Chem. 2015 Jun 5;97:55-74
pubmed: 25942353
Cells. 2018 Jul 22;7(7):
pubmed: 30037155
Gen Physiol Biophys. 2016 Jan;35(1):87-94
pubmed: 26001290
PLoS One. 2014 Dec 30;9(12):e111741
pubmed: 25548911
Gend Med. 2008 Sep;5(3):218-28
pubmed: 18727988
Front Physiol. 2016 Nov 07;7:486
pubmed: 27872595
Front Nutr. 2016 Jan 19;2:39
pubmed: 26835452
Adv Nutr. 2015 Jan 15;6(1):132-3
pubmed: 25593152
Sports Med. 2013 Oct;43(10):927-54
pubmed: 23832851
J Physiol. 2017 May 1;595(9):2915-2930
pubmed: 27748956
Appl Physiol Nutr Metab. 2013 May;38(5):507-11
pubmed: 23668757
J Physiol. 2016 Sep 15;594(18):5079-80
pubmed: 27629081
Int J Sport Nutr. 1994 Jun;4(2):89-103
pubmed: 8054964
Am J Phys Med Rehabil. 2002 Nov;81(11 Suppl):S52-69
pubmed: 12409811
ScientificWorldJournal. 2014;2014:351598
pubmed: 25431786
J Sci Med Sport. 2019 Apr;22(4):462-466
pubmed: 30297216
Antioxidants (Basel). 2018 Sep 05;7(9):
pubmed: 30189660
Medicine (Baltimore). 2016 May;95(20):e3657
pubmed: 27196469
Front Mol Biosci. 2017 Mar 06;4:8
pubmed: 28321398
Environ Toxicol Pharmacol. 2010 Sep;30(2):169-74
pubmed: 21787648
Biol Chem. 2007 May;388(5):547-54
pubmed: 17516851
Int J Exerc Sci. 2020 Sep 01;12(1):1-8
pubmed: 33042361
Food Nutr Res. 2015 Apr 29;59:25702
pubmed: 25933612
J Appl Toxicol. 2005 Sep-Oct;25(5):440-3
pubmed: 15986493
Nutrition. 2015 Jul-Aug;31(7-8):916-22
pubmed: 26059364