A Putative Lipid-Associating Motif in the West Nile Virus NS4A Protein Is Required for Efficient Virus Replication.
NS4A protein
RNA replication
West Nile virus
membrane remodeling
virus-host interactions
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
19
01
2021
accepted:
07
04
2021
entrez:
31
5
2021
pubmed:
1
6
2021
medline:
1
6
2021
Statut:
epublish
Résumé
Flavivirus replication is intimately associated with re-organized cellular membranes. These virus-induced changes in membrane architecture form three distinct membranous "organelles" that have specific functions during the flavivirus life cycle. One of these structures is the replication complex in which the flaviviral RNA is replicated to produce progeny genomes. We have previously observed that this process is strictly dependent on cellular cholesterol. In this study we have identified a putative cholesterol recognition/interaction amino acid consensus (CRAC) motif within the West Nile virus strain Kunjin virus (WNV
Identifiants
pubmed: 34055786
doi: 10.3389/fcell.2021.655606
pmc: PMC8149610
doi:
Types de publication
Journal Article
Langues
eng
Pagination
655606Informations de copyright
Copyright © 2021 Mikulasova, Gillespie, Ambrose, Aktepe, Trenerry, Liebscher and Mackenzie.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Cell Host Microbe. 2007 Oct 11;2(4):229-39
pubmed: 18005741
Biochem J. 2011 Aug 1;437(3):389-97
pubmed: 21592088
Science. 1985 Aug 23;229(4715):726-33
pubmed: 4023707
Traffic. 2005 Nov;6(11):967-77
pubmed: 16190978
Eur Biophys J. 2005 Feb;34(1):52-66
pubmed: 15221235
J Cell Sci. 2006 Aug 1;119(Pt 15):3149-60
pubmed: 16835267
Cell Rep. 2017 Nov 7;21(6):1639-1654
pubmed: 29117567
Cell Host Microbe. 2010 Nov 18;8(5):422-32
pubmed: 21075353
J Virol. 2010 Oct;84(20):10438-47
pubmed: 20686019
Virology. 1997 Jul 21;234(1):31-41
pubmed: 9234944
J Virol. 1997 Sep;71(9):6650-61
pubmed: 9261387
J Cell Biochem. 1993 Jul;52(3):275-88
pubmed: 7690043
J Biol Chem. 2007 Mar 23;282(12):8873-82
pubmed: 17276984
Curr Top Microbiol Immunol. 2002;267:323-51
pubmed: 12082996
J Gen Virol. 2007 Apr;88(Pt 4):1163-1168
pubmed: 17374759
Biochemistry. 2008 Jan 8;47(1):124-30
pubmed: 18081318
Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17345-50
pubmed: 20855599
Virology. 1996 Jun 1;220(1):232-40
pubmed: 8659120
J Virol Methods. 1996 Jan;56(1):67-75
pubmed: 8690769
J Gen Virol. 1993 Apr;74 ( Pt 4):733-40
pubmed: 8385698
PLoS Pathog. 2012;8(3):e1002584
pubmed: 22457619
Virology. 2009 Jun 20;389(1-2):8-19
pubmed: 19419745
J Virol. 1997 Feb;71(2):1497-505
pubmed: 8995675
Endocrinology. 1998 Dec;139(12):4991-7
pubmed: 9832438
J Virol. 1998 Sep;72(9):7270-9
pubmed: 9696822
Virology. 2015 Jul;481:95-106
pubmed: 25771497
Virology. 1999 May 25;258(1):108-17
pubmed: 10329573
J Biol Chem. 2007 Apr 6;282(14):10678-89
pubmed: 17287213
J Neurosci. 2009 May 13;29(19):6094-104
pubmed: 19439587
J Mol Biol. 2005 Jan 14;345(2):339-50
pubmed: 15571726
Nat Rev Microbiol. 2008 May;6(5):363-74
pubmed: 18414501
J Virol. 2006 May;80(9):4623-32
pubmed: 16611922
J Virol. 2012 Nov;86(21):11815-32
pubmed: 22915803
Virology. 1998 Jun 5;245(2):203-15
pubmed: 9636360
J Cell Sci. 2006 Mar 1;119(Pt 5):787-96
pubmed: 16495479
Mol Cell Proteomics. 2014 Nov;13(11):2836-54
pubmed: 24855065
Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15865-70
pubmed: 14668447
Hepatol Res. 2010 Sep;40(9):923-9
pubmed: 20887597
Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15669-74
pubmed: 12441396
J Virol. 2014 Oct;88(20):12041-54
pubmed: 25122799
J Virol. 2005 Nov;79(22):13924-33
pubmed: 16254328
J Virol. 1999 Nov;73(11):9555-67
pubmed: 10516064