Non-covalent Interaction With SUMO Enhances the Activity of Human Cytomegalovirus Protein IE1.

Immediate early proteins (IE) NMR spectroscopy SUMO cytomegalovirus host-virus interaction transactivation

Journal

Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250

Informations de publication

Date de publication:
2021
Historique:
received: 01 02 2021
accepted: 20 04 2021
entrez: 31 5 2021
pubmed: 1 6 2021
medline: 1 6 2021
Statut: epublish

Résumé

Viruses interact with the host cellular pathways to optimize cellular conditions for replication. The Human Cytomegalovirus (HCMV) Immediate-Early protein 1 (IE1) is the first viral protein to express during infection. It is a multifunctional and conditionally essential protein for HCMV infection. SUMO signaling regulates several cellular pathways that are also targets of IE1. Consequently, IE1 exploits SUMO signaling to regulate these pathways. The covalent interaction of IE1 and SUMO (IE1-SUMOylation) is well studied. However, the non-covalent interactions between SUMO and IE1 are unknown. We report two SUMO-Interacting Motifs (SIMs) in IE1, one at the end of the core domain and another in the C-terminal domain. NMR titrations showed that IE1-SIMs bind to SUMO1 but not SUMO2. Two critical functions of IE1 are inhibition of SUMOylation of Promyelocytic leukemia protein (PML) and transactivation of viral promoters. Although the non-covalent interaction of IE1 and SUMO is not involved in the inhibition of PML SUMOylation, it contributes to the transactivation activity. The transactivation activity of IE1 was previously correlated to its ability to inhibit PML SUMOylation. Our results suggest that transactivation and inhibition of PML SUMOylation are independent activities of IE1.

Identifiants

pubmed: 34055792
doi: 10.3389/fcell.2021.662522
pmc: PMC8155523
doi:

Types de publication

Journal Article

Langues

eng

Pagination

662522

Informations de copyright

Copyright © 2021 Tripathi, Chatterjee and Das.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Vasvi Tripathi (V)

National Centre for Biological Sciences, Tata Institute of Fundamental Research (TIFR), Bengaluru, India.

Kiran Sankar Chatterjee (KS)

National Centre for Biological Sciences, Tata Institute of Fundamental Research (TIFR), Bengaluru, India.

Ranabir Das (R)

National Centre for Biological Sciences, Tata Institute of Fundamental Research (TIFR), Bengaluru, India.

Classifications MeSH