Cardiovascular Impacts on COVID-19 Infected Patients.
ACE2
COVID-19
SARS-CoV-2
cardiovascular abnormalities
cardiovascular diseases
cardiovascular risk factors
cardiovascular system
severe acute respiratory syndrome corona virus 2
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
02
2021
accepted:
14
04
2021
entrez:
31
5
2021
pubmed:
1
6
2021
medline:
1
6
2021
Statut:
epublish
Résumé
The SARS-CoV-2 virus has taken more than 2 million lives on a global scale. Over 10 million people were confirmed with COVID-19 infection. The well-known spot of primary infection includes the lungs and the respiratory system. Recently it has been reported that the cardiovascular system and coagulation mechanisms were the second major targets of biological system affected due to the viral replication. The replication mechanism of SARS-CoV-2 involves the angiotensin-converting enzyme 2- (ACE2) surface receptors of endothelial cells belonging to various organs which act as the binding site for the viral spike (S) protein of SARS-CoV-2. The COVID-19 virus has been recently listed as a primary risk factor for the following cardiovascular conditions such as pericarditis, myocarditis, arrhythmias, myocardial injury, cardiac arrest, heart failure and coagulation abnormalities in the patients confirmed with COVID-19 viral infection. Direct and indirect type of tissue damage were the two major categories detected with cardiovascular abnormalities. Direct myocardial cell injury and indirect damage to the myocardial cell due to inflammation were clinically reported. Few drugs were clinically administered to regulate the vital biological mechanism along with symptomatic treatment and supportive therapy.
Identifiants
pubmed: 34055939
doi: 10.3389/fcvm.2021.670659
pmc: PMC8155350
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
670659Informations de copyright
Copyright © 2021 Raghavan, Gayathri, Kancharla, Kolli, Ranjitha and Shankar.
Déclaration de conflit d'intérêts
SK was employed by the company Devansh Lab Werks, Inc and PK was employed by the company Microgen Health Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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