Self-Assembling pH-Responsive Nanoparticle Platform Based on Pectin-Doxorubicin Conjugates for Codelivery of Anticancer Drugs.
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
20 Apr 2021
20 Apr 2021
Historique:
received:
16
12
2020
accepted:
25
01
2021
entrez:
31
5
2021
pubmed:
1
6
2021
medline:
1
6
2021
Statut:
epublish
Résumé
Pharmaceutical science based on biological nanotechnology is developing rapidly in parallel with the development of nanomaterials and nanotechnology in general. Pectin is a natural polysaccharide obtainable from a wide range of sources. Here, we show that doxorubicin (DOX)-conjugated hydrophilic pectin (PET) comprising an amphiphilic polymer loaded with hydrophobic dihydroartemisinin (DHA) self-assemble into nanoparticles. Importantly, conjugated DOX and DHA could be released quickly in a weakly acidic environment by cleavage of the acid-sensitive acyl hydrazone bond. Confocal microscopy and flow cytometry confirmed that these PET-DOX/DHA nanoparticles efficiently delivered DOX into the nuclei of MCF-7 cells. Significant tumor growth reduction was monitored in a female C57BL/6 mouse model, showing that the PET-DOX/DHA nanoparticle-mediated drug delivery system inhibited tumor growth and may improve therapy. Thus, we have demonstrated that pectin may be useful in the design of materials for biomedical applications.
Identifiants
pubmed: 34056155
doi: 10.1021/acsomega.0c06131
pmc: PMC8153661
doi:
Types de publication
Journal Article
Langues
eng
Pagination
9998-10004Informations de copyright
© 2021 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
Int J Biol Macromol. 2020 Jun 15;153:533-538
pubmed: 32114170
ACS Appl Mater Interfaces. 2019 Mar 6;11(9):8740-8748
pubmed: 30693750
J Agric Food Chem. 2017 Aug 16;65(32):6840-6847
pubmed: 28721737
Nutrients. 2019 Nov 01;11(11):
pubmed: 31683865
Adv Sci (Weinh). 2018 May 09;5(7):1800155
pubmed: 30027047
Adv Healthc Mater. 2018 Apr;7(7):e1701272
pubmed: 29334184
Sci Rep. 2020 Feb 3;10(1):1690
pubmed: 32015377
FASEB J. 2009 Feb;23(2):415-24
pubmed: 18832596
Mol Pharm. 2010 Dec 6;7(6):1913-20
pubmed: 20836539
ACS Appl Mater Interfaces. 2018 Jun 13;10(23):19355-19364
pubmed: 29757607
Semin Cancer Biol. 2014 Aug;27:30-8
pubmed: 24657939
Clin Cancer Res. 2008 Mar 1;14(5):1310-6
pubmed: 18316549
Biomed Pharmacother. 2016 Dec;84:637-644
pubmed: 27697635
J Agric Food Chem. 2018 Aug 1;66(30):8015-8025
pubmed: 29987933
Mol Pharm. 2012 Sep 4;9(9):2380-402
pubmed: 22844998
ISME J. 2019 Jun;13(6):1437-1456
pubmed: 30728469
ACS Appl Mater Interfaces. 2018 Aug 8;10(31):25983-25993
pubmed: 30014692
Bioorg Med Chem. 2009 Apr 15;17(8):2950-62
pubmed: 19299149
Artif Cells Nanomed Biotechnol. 2018;46(sup1):264-273
pubmed: 29298530
Integr Cancer Ther. 2013 Mar;12(2):145-52
pubmed: 22532035
ACS Appl Mater Interfaces. 2017 Sep 13;9(36):30519-30535
pubmed: 28819967
Acta Biomater. 2018 Jan 15;66:310-324
pubmed: 29129789
Glycobiology. 2007 Aug;17(8):805-19
pubmed: 17513886
Chem Eng Sci. 2015 Mar 24;125:158-164
pubmed: 25684780
J Control Release. 2001 Jan 29;70(1-2):1-20
pubmed: 11166403