Combinatorial Design of a Sialic Acid-Imprinted Binding Site.
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
11 May 2021
11 May 2021
Historique:
received:
01
03
2021
accepted:
22
04
2021
entrez:
31
5
2021
pubmed:
1
6
2021
medline:
1
6
2021
Statut:
epublish
Résumé
Aberrant glycosylation has been proven to correlate with various diseases including cancer. An important alteration in cancer progression is an increased level of sialylation, making sialic acid one of the key constituents in tumor-specific glycans and an interesting biomarker for a diversity of cancer types. Developing molecularly imprinted polymers (MIPs) with high affinity toward sialic acids is an important task that can help in early cancer diagnosis. In this work, the glycospecific MIPs are produced using cooperative covalent/noncovalent imprinting. We report here on the fundamental investigation of this termolecular imprinting approach. This comprises studies of the relative contribution of orthogonally interacting functional monomers and their synergetic behavior and the choice of different counterions on the molecular recognition properties for the sialylated targets. Combining three functional monomers targeting different functionalities on the template led to enhanced imprinting factors (IFs) and selectivities. This apparent cooperative effect was supported by
Identifiants
pubmed: 34056377
doi: 10.1021/acsomega.1c01111
pmc: PMC8154165
doi:
Types de publication
Journal Article
Langues
eng
Pagination
12229-12237Informations de copyright
© 2021 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
Nano Lett. 2020 Jul 8;20(7):5106-5110
pubmed: 32501718
Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5998-6003
pubmed: 24711415
Chem Commun (Camb). 2015 Feb 7;51(11):2005-20
pubmed: 25465854
Acc Chem Res. 2017 Sep 19;50(9):2185-2193
pubmed: 28849912
J Proteome Res. 2010 Jun 4;9(6):3062-72
pubmed: 20345175
J Org Chem. 2005 Mar 4;70(5):1732-6
pubmed: 15730295
Chemistry. 2008;14(31):9516-29
pubmed: 18850612
Glycobiology. 2001 Aug;11(8):621-32
pubmed: 11479273
Biochem J. 1991 Sep 15;278 ( Pt 3):689-95
pubmed: 1898357
Anal Biochem. 2005 Apr 1;339(1):69-72
pubmed: 15766712
J Am Chem Soc. 2015 Nov 4;137(43):13908-12
pubmed: 26414878
Lab Invest. 2007 Sep;87(9):851-7
pubmed: 17632542
ACS Chem Biol. 2010 Feb 19;5(2):163-76
pubmed: 20020717
Angew Chem Int Ed Engl. 2016 Mar 1;55(10):3387-92
pubmed: 26822115
J Am Chem Soc. 2003 Mar 26;125(12):3493-502
pubmed: 12643711
Org Biomol Chem. 2005 May 7;3(9):1593-608
pubmed: 15858635
J Am Chem Soc. 2017 Jan 18;139(2):829-835
pubmed: 27983819
Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10211-5
pubmed: 26179149
Tumour Biol. 2016 Oct;37(10):13763-13768
pubmed: 27476172
Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7465-7470
pubmed: 30910970
Chem Soc Rev. 2013 Jun 7;42(11):4798-813
pubmed: 23353569
Cancer Res. 1999 Mar 15;59(6):1337-46
pubmed: 10096568
J Biol Chem. 2000 Jun 9;275(23):17541-8
pubmed: 10747930
Biomolecules. 2015 Aug 11;5(3):1783-809
pubmed: 26270678
Cancer Res. 2008 Jan 15;68(2):388-94
pubmed: 18199532
Biosens Bioelectron. 2017 Feb 15;88:85-93
pubmed: 27481167
Chem Commun (Camb). 2011 Jan 28;47(4):1106-23
pubmed: 21116582