Harnessing the anti-inflammatory properties of stem cells for transplant therapy in hemorrhagic stroke.
Journal
Brain hemorrhages
ISSN: 2589-238X
Titre abrégé: Brain Hemorrhages
Pays: Netherlands
ID NLM: 101763734
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
entrez:
31
5
2021
pubmed:
1
3
2020
medline:
1
3
2020
Statut:
ppublish
Résumé
Hemorrhagic stroke is a global health crisis plagued by neuroinflammation in the acute and chronic phases. Neuroinflammation approximates secondary cell death, which in turn robustly contributes to stroke pathology. Both the physiological and behavioral symptoms of stroke correlate with various inflammatory responses in animal and human studies. That slowing the secondary cell death mediated by this inflammation may attenuate stroke pathology presents a novel treatment strategy. To this end, experimental therapies employing stem cell transplants support their potential for neuroprotection and neuroregeneration after hemorrhagic stroke. In this review, we evaluate experiments using different types of stem cell transplants as treatments for stroke-induced neuroinflammation. We also update this emerging area by examining recent preclinical and clinical trials that have deployed these therapies. While further investigations are warranted to solidify their therapeutic profile, the reviewed studies largely posit stem cells as safe and potent biologics for stroke, specifically owing to their mode of action for sequestering neuroinflammation and promoting neuroregenerative processes.
Identifiants
pubmed: 34056567
doi: 10.1016/j.hest.2019.12.005
pmc: PMC8158660
mid: NIHMS1569682
doi:
Types de publication
Journal Article
Langues
eng
Pagination
24-33Subventions
Organisme : NINDS NIH HHS
ID : R01 NS090962
Pays : United States
Déclaration de conflit d'intérêts
Conflict of interest Cesar V Borlongan holds patents and patent applications on stem cell biology and their therapeutic applications, and receives royalties and consultancy fees from stem cell companies.
Références
PLoS One. 2015 Oct 02;10(10):e0138973
pubmed: 26431046
J Transl Med. 2009 Nov 17;7:97
pubmed: 19919699
Brain Behav. 2013 Nov;3(6):649-55
pubmed: 24363968
Nat Med. 2003 Nov;9(11):1370-6
pubmed: 14556003
Cell Transplant. 2017 Feb 16;26(2):243-257
pubmed: 27677799
Nat Med. 1999 Apr;5(4):434-8
pubmed: 10202935
J Clin Invest. 2005 Oct;115(10):2592-7
pubmed: 16200191
Prog Brain Res. 2000;127:461-76
pubmed: 11142041
Front Syst Neurosci. 2014 Jun 24;8:116
pubmed: 25009475
Neurochem Res. 2009 Jul;34(7):1304-16
pubmed: 19152028
PLoS One. 2014 Dec 01;9(12):e113972
pubmed: 25437857
PLoS One. 2014 Sep 04;9(9):e106346
pubmed: 25187991
Brain Res. 2015 Jan 12;1594:267-73
pubmed: 25452023
Macromol Biosci. 2017 Apr;17(4):
pubmed: 27792283
Am J Physiol Cell Physiol. 2010 Dec;299(6):C1562-70
pubmed: 20861473
J Cardiovasc Transl Res. 2013 Oct;6(5):834-51
pubmed: 24006091
PLoS One. 2012;7(8):e43779
pubmed: 22912905
Brain Res. 2004 Jun 4;1010(1-2):108-16
pubmed: 15126123
Stem Cell Res Ther. 2011 Aug 11;2(4):34
pubmed: 21861858
Exp Clin Transplant. 2014 Apr;12(2):171-2
pubmed: 24702151
PLoS One. 2016 Jan 11;11(1):e0146353
pubmed: 26752061
Cell Transplant. 2017 Jan 24;26(1):45-61
pubmed: 27501782
Int J Biochem Cell Biol. 2016 Oct;79:360-369
pubmed: 27594413
Transl Res. 2016 Oct;176:69-80
pubmed: 27164406
Cell Transplant. 2016;25(8):1473-88
pubmed: 26996530
Cell Transplant. 2013;22(5):871-9
pubmed: 22469567
Neuropsychiatr Dis Treat. 2016 Jun 02;12:1287-93
pubmed: 27330296
J Neurol. 2007 Mar;254(3):327-32
pubmed: 17345048
Dev Neurosci. 2013;35(4):293-305
pubmed: 23751520
Stem Cells. 2012 Mar;30(3):510-24
pubmed: 22134901
Ann Neurol. 2005 Jun;57(6):874-82
pubmed: 15929052
J Cereb Blood Flow Metab. 2013 Sep;33(9):1322-34
pubmed: 23756689
Cell. 2006 Aug 25;126(4):663-76
pubmed: 16904174
Cell Immunol. 2012;274(1-2):46-53
pubmed: 22414555
Cell Death Differ. 2012 May;19(5):756-67
pubmed: 22052192
Front Neurol. 2018 Oct 24;9:895
pubmed: 30405520
Cell Transplant. 2010;19(5):525-36
pubmed: 20144262
Stem Cell Res Ther. 2015 Mar 24;6:44
pubmed: 25888925
Lancet. 2016 Aug 20;388(10046):787-96
pubmed: 27497862
FASEB J. 2018 May;32(5):2381-2394
pubmed: 29269399
NeuroRx. 2006 Oct;3(4):466-73
pubmed: 17012060
Stem Cell Res. 2010 May;4(3):214-22
pubmed: 20138817
Circ Res. 2012 Feb 17;110(4):624-37
pubmed: 22343557
PLoS One. 2010 Jan 05;5(1):e8575
pubmed: 20052410
Cell Transplant. 2009;18(9):985-98
pubmed: 19523333
Ann Neurol. 2011 Jul;70(1):59-69
pubmed: 21786299
Stem Cell Rev Rep. 2019 Jun;15(3):391-403
pubmed: 31089880
Lancet Neurol. 2017 May;16(5):360-368
pubmed: 28320635
Stroke. 2016 Jul;47(7):1817-24
pubmed: 27256670
Nat Med. 2011 Jul 07;17(7):796-808
pubmed: 21738161
J Immunol Res. 2015;2015:394917
pubmed: 25961059
J Am Heart Assoc. 2014 Sep 18;3(5):e001194
pubmed: 25237049
Stem Cells. 2015 Feb;33(2):491-502
pubmed: 25267362
Transl Stroke Res. 2018 Jun;9(3):306-316
pubmed: 29110250
World J Gastroenterol. 2013 Aug 7;19(29):4702-17
pubmed: 23922467
J Neurosci Res. 2008 Jul;86(9):1936-43
pubmed: 18335525
Tissue Eng Part A. 2010 Nov;16(11):3537-46
pubmed: 20597819
Stem Cells Dev. 2018 Aug 15;27(16):1085-1096
pubmed: 29893190
Prog Neurobiol. 2017 Nov;158:94-131
pubmed: 28743464
Front Biosci. 2006 Jan 01;11:760-75
pubmed: 16146768
J Cereb Blood Flow Metab. 2010 Aug;30(8):1487-93
pubmed: 20216552
Lancet. 1999 Apr;353 Suppl 1:SI29-30
pubmed: 10319932
Transl Stroke Res. 2018 Oct;9(5):530-539
pubmed: 29285679
Stroke. 2010 Jan;41(1):153-9
pubmed: 19940279
Zhonghua Yi Xue Za Zhi. 2015 Aug 25;95(32):2630-3
pubmed: 26711615
J Stroke Cerebrovasc Dis. 2019 Jul;28(7):1979-1986
pubmed: 30982718
Sci Rep. 2019 Apr 5;9(1):5674
pubmed: 30952961
Cell Commun Signal. 2011 May 14;9:12
pubmed: 21569606
Front Neurol. 2019 Apr 10;10:357
pubmed: 31024439
Stem Cell Res Ther. 2014 Nov 23;5(6):129
pubmed: 25418536
J Neurosurg. 1993 Feb;78(2):188-91
pubmed: 8421201
Sci Rep. 2015 Nov 20;5:16941
pubmed: 26585689
Neural Regen Res. 2018 Aug;13(8):1346-1349
pubmed: 30106038
Leukemia. 2006 May;20(5):857-69
pubmed: 16498386
Nat Med. 2004 Jul;10 Suppl:S42-50
pubmed: 15272269
Stroke. 2009 Apr;40(4):1237-44
pubmed: 19246697
J Stem Cell Res Ther. 2013 May 1;4(4):12912
pubmed: 24077523
Stem Cells Transl Med. 2014 Nov;3(11):1322-30
pubmed: 25107583
Stem Cells Dev. 2009 Jun;18(5):693-702
pubmed: 19199787
Front Neurol. 2018 Feb 06;9:34
pubmed: 29467713
Cell Mol Neurobiol. 2017 Mar;37(2):303-313
pubmed: 27044018
Neural Regen Res. 2014 Aug 1;9(15):1425-9
pubmed: 25317152
Brain Res. 2010 Feb 22;1315:128-36
pubmed: 20004649
Regen Med. 2008 May;3(3):249-50
pubmed: 18462048
Sci Rep. 2016 Sep 09;6:33038
pubmed: 27609711
Stem Cells Transl Med. 2018 Jul;7(7):521-529
pubmed: 29752869
Neurosci Lett. 2008 Nov 7;445(1):36-41
pubmed: 18755241
Circulation. 2013 Jan 1;127(1):e6-e245
pubmed: 23239837
Circulation. 2004 Sep 28;110(13):1847-54
pubmed: 15381647
Biochimie. 2013 Dec;95(12):2271-85
pubmed: 23827856
Amyotroph Lateral Scler Other Motor Neuron Disord. 2003 Sep;4(3):158-61
pubmed: 13129802
Nat Rev Neurosci. 2011 Mar;12(3):169-82
pubmed: 21331083
J Biomed Nanotechnol. 2018 Jun 1;14(6):1178-1188
pubmed: 29843882
Nature. 2007 Oct 4;449(7162):557-63
pubmed: 17914389
Cytotherapy. 2015 Nov;17(11):1560-71
pubmed: 26432559
Exp Ther Med. 2018 Sep;16(3):2219-2228
pubmed: 30186461
Stem Cells Transl Med. 2013 Sep;2(9):703-14
pubmed: 23934909
Open Orthop J. 2011;5 Suppl 2:242-8
pubmed: 21886689
Exp Neurol. 1998 Feb;149(2):310-21
pubmed: 9500961
Dtsch Arztebl Int. 2015 Jan 23;112(4):51-8
pubmed: 25797423
J Cereb Blood Flow Metab. 2019 Sep;39(9):1750-1758
pubmed: 29569981
ScientificWorldJournal. 2012;2012:758512
pubmed: 22701372
Leukemia. 2011 Nov;25(11):1674-86
pubmed: 21727900
Stroke. 2009 Mar;40(3 Suppl):S146-8
pubmed: 19064801
Immunology. 2009 Feb;126(2):220-32
pubmed: 18624725
Cell Transplant. 2011;20(6):883-91
pubmed: 21054935
Mol Ther. 2005 Jan;11(1):96-104
pubmed: 15585410
J Atheroscler Thromb. 2018 Apr 1;25(4):350-358
pubmed: 29093276
Exp Neurol. 2003 Jun;181(2):115-29
pubmed: 12781986
Exp Hematol. 2002 Jan;30(1):42-8
pubmed: 11823036
Stroke. 2015 Jul;46(7):1938-46
pubmed: 26045601
Sheng Li Xue Bao. 2014 Dec 25;66(6):691-701
pubmed: 25516518
Brain Res. 2016 Jul 1;1642:426-435
pubmed: 27085204
J Neurosci Res. 2015 Dec;93(12):1814-25
pubmed: 26332684
Mol Cell Biochem. 2012 Jun;365(1-2):1-7
pubmed: 21964561
Stem Cells Dev. 2018 Mar 1;27(5):355-366
pubmed: 29298609
Stem Cells Transl Med. 2015 Jul;4(7):841-51
pubmed: 26025980
Cell. 2018 May 3;173(4):851-863.e16
pubmed: 29576452
Placenta. 2007 Nov-Dec;28(11-12):1174-81
pubmed: 17714779
CNS Neurosci Ther. 2015 Nov;21(11):877-86
pubmed: 26384586
Arch Biochem Biophys. 2013 Jun;534(1-2):88-97
pubmed: 23466243
Emerg Med Clin North Am. 2019 Aug;37(3):529-544
pubmed: 31262419
J Cell Mol Med. 2011 Jun;15(6):1319-28
pubmed: 20629987
Stroke. 2015 Feb;46(2):588-91
pubmed: 25503552
J Cell Biochem. 2012 Jun;113(6):1886-95
pubmed: 22234854
Stem Cell Rev Rep. 2011 Mar;7(1):208-20
pubmed: 20526754
Stem Cells Dev. 2010 Nov;19(11):1757-67
pubmed: 20192839
Stem Cells. 2010 Jun;28(6):1099-106
pubmed: 20506226
Neuroepidemiology. 2015;45(3):152-60
pubmed: 26505189
Stroke. 2015 Sep;46(9):2616-27
pubmed: 26219646
Stem Cell Rev Rep. 2018 Oct;14(5):686-693
pubmed: 30022351
Stem Cells Transl Med. 2017 Jan;6(1):223-237
pubmed: 28170190
J Clin Med. 2013 Dec;2(4):220-241
pubmed: 25177494
Hum Reprod Update. 2016 Dec;23(1):41-76
pubmed: 27614362
Pediatr Res. 2012 Apr;71(4 Pt 2):464-73
pubmed: 22430382
Neuropathology. 2011 Aug;31(4):384-91
pubmed: 21175862
J Biol Chem. 2010 Apr 9;285(15):11227-34
pubmed: 20139068
J Neurosci. 2019 Aug 14;39(33):6571-6594
pubmed: 31263065
Stem Cells Dev. 2009 Dec;18(10):1501-14
pubmed: 19301956
Cell Transplant. 2019 Jul;28(7):864-873
pubmed: 31066288
Front Biosci. 2006 Jan 01;11:1090-101
pubmed: 16146799
Nature. 2011 May 13;474(7350):212-5
pubmed: 21572395
PLoS One. 2019 Jan 25;14(1):e0210198
pubmed: 30682162
Stroke. 2014 Dec;45(12):3618-24
pubmed: 25378424
Stem Cells Dev. 2014 Apr 1;23(7):689-701
pubmed: 24372153
Neurosci Lett. 2019 Aug 24;708:134346
pubmed: 31229624
Mol Reprod Dev. 2013 Aug;80(8):677-90
pubmed: 23440892
Clin Lymphoma Myeloma Leuk. 2015 Oct;15(10):606-11
pubmed: 26184063
Curr Pharm Des. 2012;18(25):3670-6
pubmed: 22574981
Mol Cell Biochem. 2011 Aug;354(1-2):67-75
pubmed: 21465238
Acta Cir Bras. 2012 Apr;27(4):333-9
pubmed: 22534809
Clin Neurol Neurosurg. 2019 May;180:1-6
pubmed: 30870760
Pharmacol Res. 2019 Jun;144:181-191
pubmed: 31004788
Brain Res Bull. 2019 Jul;149:42-52
pubmed: 31002912
Thromb Haemost. 2015 May;113(5):1084-94
pubmed: 25608764
Nat Med. 2016 Nov;22(11):1358-1367
pubmed: 27668937
Brain. 2008 Mar;131(Pt 3):616-29
pubmed: 18156155
Arterioscler Thromb Vasc Biol. 2004 Feb;24(2):288-93
pubmed: 14699017
J Immunol. 2018 Oct 15;201(8):2414-2426
pubmed: 30201810
Cytotherapy. 2016 Oct;18(10):1270-83
pubmed: 27543068
PLoS One. 2014 Nov 11;9(11):e111938
pubmed: 25386685
Neurorehabil Neural Repair. 2015 Jan;29(1):80-9
pubmed: 24633139
J Cell Mol Med. 2014 Sep;18(9):1797-806
pubmed: 24895014
Expert Opin Biol Ther. 2015 Jul;15(7):949-58
pubmed: 25943632
Stem Cell Res Ther. 2016 Aug 11;7(1):109
pubmed: 27515534
Stroke. 2018 May;49(5):1091-1098
pubmed: 29669871
Neuroreport. 2010 Jun 2;21(8):575-9
pubmed: 20431496
Stem Cells Dev. 2010 Apr;19(4):439-52
pubmed: 19860544
Stem Cells Int. 2015;2015:819084
pubmed: 26060498
J Immunol. 2010 Dec 1;185(11):6617-23
pubmed: 20980628
Leukemia. 2007 Feb;21(2):297-303
pubmed: 17136117
Cell Stem Cell. 2013 Jul 3;13(1):102-16
pubmed: 23827712
J Neuroinflammation. 2010 Nov 01;7:74
pubmed: 21040547
Front Neuroeng. 2013 Aug 30;6:7
pubmed: 24009582
Exp Neurol. 2000 Aug;164(2):247-56
pubmed: 10915564
Stem Cells. 2017 May;35(5):1246-1258
pubmed: 28142208
Stem Cell Rev Rep. 2019 Apr;15(2):256-275
pubmed: 30739275
Curr Neurovasc Res. 2019;16(1):19-26
pubmed: 30706812
Neural Regen Res. 2016 Jun;11(6):1015-24
pubmed: 27482235
Stem Cells. 2007 Feb;25(2):371-9
pubmed: 17038675
Surgery. 2015 Sep;158(3):846-56
pubmed: 26266763
Br J Clin Pharmacol. 2009 Oct;68(4):484-92
pubmed: 19843051
Sci Rep. 2016 Feb 05;6:20588
pubmed: 26846186
Neurosci Lett. 2003 May 15;342(1-2):93-6
pubmed: 12727326
Stem Cell Res Ther. 2011 Sep 22;2(5):38
pubmed: 21939558
Aging (Albany NY). 2012 Apr;4(4):235-46
pubmed: 22498452
J Neurosci Res. 2009 Aug 1;87(10):2183-200
pubmed: 19301431
J Cereb Blood Flow Metab. 2008 Feb;28(2):329-40
pubmed: 17637706
Am J Physiol Heart Circ Physiol. 2006 Apr;290(4):H1378-86
pubmed: 16299259
Nat Med. 2002 Sep;8(9):963-70
pubmed: 12161747
Cell Transplant. 2011;20(6):789-95
pubmed: 21054947
J Neurosci Res. 2006 Nov 15;84(7):1495-504
pubmed: 16998918
CNS Neurosci Ther. 2013 Feb;19(2):67-75
pubmed: 23230897
J Mol Cell Cardiol. 2007 Jun;42(6):1086-97
pubmed: 17490680
Arterioscler Thromb Vasc Biol. 2019 Sep;39(9):e195-e207
pubmed: 31315437
Exp Neurol. 2008 Apr;210(2):656-70
pubmed: 18279854
Cell Transplant. 2013;22(6):977-91
pubmed: 23031629