Association Cortex Is Essential to Reverse Hemianopia by Multisensory Training.
colliculus
ectosylvian
hemianopia
multisensory
rehabilitation
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
01 10 2021
01 10 2021
Historique:
received:
20
01
2021
revised:
19
04
2021
accepted:
19
04
2021
pubmed:
1
6
2021
medline:
1
4
2022
entrez:
31
5
2021
Statut:
ppublish
Résumé
Hemianopia induced by unilateral visual cortex lesions can be resolved by repeatedly exposing the blinded hemifield to auditory-visual stimuli. This rehabilitative "training" paradigm depends on mechanisms of multisensory plasticity that restore the lost visual responsiveness of multisensory neurons in the ipsilesional superior colliculus (SC) so that they can once again support vision in the blinded hemifield. These changes are thought to operate via the convergent visual and auditory signals relayed to the SC from association cortex (the anterior ectosylvian sulcus [AES], in cat). The present study tested this assumption by cryogenically deactivating ipsilesional AES in hemianopic, anesthetized cats during weekly multisensory training sessions. No signs of visual recovery were evident in this condition, even after providing animals with up to twice the number of training sessions required for effective rehabilitation. Subsequent training under the same conditions, but with AES active, reversed the hemianopia within the normal timeframe. These results indicate that the corticotectal circuit that is normally engaged in SC multisensory plasticity has to be operational for the brain to use visual-auditory experience to resolve hemianopia.
Identifiants
pubmed: 34056645
pii: 6287334
doi: 10.1093/cercor/bhab138
pmc: PMC8491673
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
5015-5023Subventions
Organisme : NEI NIH HHS
ID : R01 EY026916
Pays : United States
Organisme : NIH HHS
ID : EY026916
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Références
Front Neural Circuits. 2016 Jan 19;9:85
pubmed: 26834568
Nat Commun. 2015 May 29;6:7263
pubmed: 26021613
Science. 1985 Feb 8;227(4687):657-9
pubmed: 3969558
J Neurosci. 1993 Oct;13(10):4538-48
pubmed: 8410202
Physiol Int. 2019 Jun 1;106(2):95-113
pubmed: 31271309
Neuroscience. 2001;106(4):765-81
pubmed: 11682162
Trends Neurosci. 2005 Aug;28(8):401-7
pubmed: 15982753
Cortex. 2018 May;102:161-175
pubmed: 28958417
Prog Brain Res. 1993;95:139-50
pubmed: 8493327
Perception. 2008;37(3):408-18
pubmed: 18491718
Sensors (Basel). 2010;10(4):3218-42
pubmed: 22319295
Eur J Neurosci. 2013 May;37(10):1594-601
pubmed: 23534923
Cereb Cortex. 2020 Apr 14;30(4):2030-2041
pubmed: 31799618
J Neurosci. 2009 May 20;29(20):6580-92
pubmed: 19458228
Neuropsychologia. 2020 Apr;141:107413
pubmed: 32113921
Exp Brain Res. 2007 May;179(2):325-38
pubmed: 17146648
J Neurophysiol. 1993 Jun;69(6):1797-809
pubmed: 8350124
J Neurosci. 2020 May 6;40(19):3768-3782
pubmed: 32253361
Exp Brain Res. 2007 Jun;180(1):153-61
pubmed: 17546470
J Cogn Neurosci. 2002 Nov 15;14(8):1240-55
pubmed: 12495529
Nat Rev Neurosci. 2014 Aug;15(8):520-35
pubmed: 25158358
Neuron. 2019 Dec 18;104(6):1141-1152.e4
pubmed: 31668485
J Neurosci. 2009 Dec 16;29(50):15910-22
pubmed: 20016107
J Neurosci. 2007 Nov 21;27(47):12775-86
pubmed: 18032649
Neurosci Lett. 2011 Sep 26;503(1):52-7
pubmed: 21864648
Physiol Rev. 1986 Jan;66(1):118-71
pubmed: 3511480
Exp Brain Res. 1994;101(1):123-39
pubmed: 7843291
Eur J Neurosci. 2019 Dec;50(11):3702-3712
pubmed: 31430406
J Neurophysiol. 2015 Oct;114(4):2118-31
pubmed: 26203103
Elife. 2020 Apr 14;9:
pubmed: 32286224
Neuron. 2019 Aug 21;103(4):563-581
pubmed: 31437453
J Comp Neurol. 1990 Jun 8;296(2):222-52
pubmed: 2358533
Eur J Neurosci. 2006 Aug;24(3):917-24
pubmed: 16930419
Science. 1972 Aug 4;177(4047):444-7
pubmed: 5043147
J Neurophysiol. 2003 Oct;90(4):2123-35
pubmed: 14534263
Neurology. 2006 Mar 28;66(6):901-5
pubmed: 16567709
J Neurosci. 2014 May 21;34(21):7198-202
pubmed: 24849354
J Comp Neurol. 2001 Dec 3;441(1):44-57
pubmed: 11745634
Annu Rev Neurosci. 2013 Jul 8;36:165-82
pubmed: 23682659
J Neurosci. 1986 Mar;6(3):723-33
pubmed: 3958791
J Neurophysiol. 2013 Jan;109(2):464-74
pubmed: 23114212
J Neurophysiol. 2001 Feb;85(2):506-22
pubmed: 11160489
Front Syst Neurosci. 2020 Jan 31;14:4
pubmed: 32076401
J Comp Neurol. 1989 Jun 15;284(3):429-50
pubmed: 2754044
Neuroscience. 2004;124(3):535-47
pubmed: 14980725
Brain Behav Evol. 1981;19(3-4):180-92
pubmed: 7326575
Exp Neurol. 1971 Dec;33(3):629-52
pubmed: 5132203
Nat Commun. 2019 Jan 11;10(1):135
pubmed: 30635570
Ann N Y Acad Sci. 2008 Mar;1124:98-110
pubmed: 18400926
Exp Neurol. 1965 Jan;11:115-46
pubmed: 14272555
Brain. 2008 Mar;131(Pt 3):855-65
pubmed: 18263626
Neuroscience. 1997 May;78(1):179-89
pubmed: 9135099
J Neurophysiol. 2007 Jan;97(1):557-62
pubmed: 16971678
Clin Ophthalmol. 2014 Sep 22;8:1919-27
pubmed: 25284978
J Neurosci. 2017 May 17;37(20):5183-5194
pubmed: 28450539
Sci Rep. 2017 Jul 6;7(1):4772
pubmed: 28684852
Neuron. 2012 Aug 23;75(4):556-71
pubmed: 22920249
Brain Res Bull. 1983 Jun;10(6):859-60
pubmed: 6616276
Exp Neurol. 1978 Aug;61(1):96-120
pubmed: 680076
Prog Brain Res. 2011;191:211-31
pubmed: 21741554
Annu Rev Neurosci. 2011;34:205-31
pubmed: 21456962
J Neurophysiol. 1995 Jun;73(6):2334-48
pubmed: 7666142
Front Integr Neurosci. 2020 Apr 21;14:18
pubmed: 32425761
J Neurophysiol. 2006 Mar;95(3):1380-96
pubmed: 16267111
Science. 1991 Mar 15;251(4999):1358-60
pubmed: 2003221
Front Syst Neurosci. 2017 Aug 29;11:64
pubmed: 28912694
Restor Neurol Neurosci. 2015;33(4):405-19
pubmed: 26409401
Science. 1966 Sep 23;153(3743):1544-7
pubmed: 5917786
J Neurosci Methods. 1999 Jan;86(2):179-94
pubmed: 10065985
J Neurosci. 2007 May 30;27(22):5879-84
pubmed: 17537958
Biol Cybern. 2012 Dec;106(11-12):691-713
pubmed: 23011260
J Cogn Neurosci. 2005 Sep;17(9):1442-52
pubmed: 16197697
Annu Rev Neurosci. 2008;31:25-46
pubmed: 18275283
Prog Brain Res. 1996;112:313-23
pubmed: 8979838
Neuron. 2004 Sep 30;44(1):23-30
pubmed: 15450157
Exp Brain Res. 1996 Nov;112(1):1-10
pubmed: 8951401
Front Behav Neurosci. 2015 Jul 27;9:192
pubmed: 26283935
Brain Res. 1976 Dec 24;118(3):469-74
pubmed: 1009430