Focused ultrasound tumour ablation in small animal oncology.
HIFU
comparative oncology
histotripsy
immunology
minimally invasive
Journal
Veterinary and comparative oncology
ISSN: 1476-5829
Titre abrégé: Vet Comp Oncol
Pays: England
ID NLM: 101185242
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
revised:
29
04
2021
received:
11
01
2021
accepted:
24
05
2021
pubmed:
1
6
2021
medline:
27
1
2022
entrez:
31
5
2021
Statut:
ppublish
Résumé
The cancer incidence rates for humans and animals remain high, and efforts to improve cancer treatment are crucial. Cancer treatment for solid tumours includes both treatment of the primary tumour and of metastasis. Surgery is commonly employed to resect primary and metastatic tumours, but is invasive, and is not always the optimal treatment modality. Prevention and treatment of metastatic disease often utilizes a multimodal approach, but metastasis remains a major cause of death for both human and veterinary cancer patients. Focused ultrasound (FUS) tumour ablation techniques represent a novel non-invasive approach to treating cancer. FUS ablation is precise, thus sparing adjacent critical structures while ablating the tumour. FUS ablation can occur in a thermal or non-thermal fashion. Thermal FUS ablation, also known as high intensity focused ultrasound (HIFU) ablation, destroys tumour cells via heat, whereas non-thermal FUS, known as histotripsy, ablates tumour cells via mechanical disintegration of tissue. Not only can HIFU and histotripsy ablate tumours, they also demonstrate potential to upregulate the host immune system towards an anti-tumour response. The aim of this report is provide a description of HIFU and histotripsy tumour ablation, with a focus on the basic principles of their ablation mechanisms and their clinical applicability in the field of veterinary oncology.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
411-419Subventions
Organisme : American Kennel Club Canine Health Foundation
ID : 453020
Organisme : Focused Ultrasound Foundation
ID : 453045
Organisme : NIH HHS
ID : 412613
Pays : United States
Organisme : Grayton Friedlander Memorial Fund
Organisme : NIH HHS
ID : 412613
Pays : United States
Informations de copyright
© 2021 John Wiley & Sons Ltd.
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