An evaluation of remineralised MIH using CPP-ACP and fluoride varnish: An in-situ and in-vitro study.
Fluoride
Mineralized tissue/development
Pediatric dentistry
Prevention
Remineralization
Scanning electron microscope
Supportive oral care
Journal
European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry
ISSN: 1996-9805
Titre abrégé: Eur Arch Paediatr Dent
Pays: England
ID NLM: 101277157
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
12
12
2020
accepted:
05
05
2021
pubmed:
1
6
2021
medline:
19
3
2022
entrez:
31
5
2021
Statut:
ppublish
Résumé
Molar incisor hypomineralization (MIH) affected teeth have enamel with altered mineral content like decreased calcium and phosphorus and increased carbon content leading to porous enamel and subsequent post-eruptive breakdown. An in situ study was conducted to evaluate and compare the effects of a Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP)-based cream and fluoride varnish on the remineralization of MIH affected teeth. Enamel slabs were prepared from MIH affected teeth that had been extracted for various reasons and inserted in appliances of 30 participants who were undergoing interceptive orthodontic therapy. They were randomly divided into two groups using block randomization technique: Group A-daily single application of CPP-ACP cream (n = 15); Group B-professional application of fluoride varnishes every 3 months (n = 15). After 6 months of regular wear of the appliance, the enamel slabs were placed under Field Emission Scanning Microscope (FESEM) and Energy-Dispersive Spectroscopy (EDS) for evaluation of ultra structure and mineral content, respectively. A significant increase in calcium and phosphorus content, and a decrease in carbon content was observed within the 6 months period, suggesting remineralization in both the groups. On comparing the Ca:P and Ca:C ratios, a significant increase in the Ca:C ratio was evident in the two groups. No significant difference was seen in the Ca:P ratio in the CPP-ACP group at six months. The inter-group comparison did not reveal any significant difference between the two groups either at baseline or at 6 months post-intervention. Remineralization can be achieved in MIH affected teeth with the use of remineralizing agents.
Sections du résumé
BACKGROUND
BACKGROUND
Molar incisor hypomineralization (MIH) affected teeth have enamel with altered mineral content like decreased calcium and phosphorus and increased carbon content leading to porous enamel and subsequent post-eruptive breakdown.
AIM
OBJECTIVE
An in situ study was conducted to evaluate and compare the effects of a Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP)-based cream and fluoride varnish on the remineralization of MIH affected teeth.
METHODS
METHODS
Enamel slabs were prepared from MIH affected teeth that had been extracted for various reasons and inserted in appliances of 30 participants who were undergoing interceptive orthodontic therapy. They were randomly divided into two groups using block randomization technique: Group A-daily single application of CPP-ACP cream (n = 15); Group B-professional application of fluoride varnishes every 3 months (n = 15). After 6 months of regular wear of the appliance, the enamel slabs were placed under Field Emission Scanning Microscope (FESEM) and Energy-Dispersive Spectroscopy (EDS) for evaluation of ultra structure and mineral content, respectively.
RESULTS
RESULTS
A significant increase in calcium and phosphorus content, and a decrease in carbon content was observed within the 6 months period, suggesting remineralization in both the groups. On comparing the Ca:P and Ca:C ratios, a significant increase in the Ca:C ratio was evident in the two groups. No significant difference was seen in the Ca:P ratio in the CPP-ACP group at six months. The inter-group comparison did not reveal any significant difference between the two groups either at baseline or at 6 months post-intervention.
CONCLUSION
CONCLUSIONS
Remineralization can be achieved in MIH affected teeth with the use of remineralizing agents.
Identifiants
pubmed: 34057698
doi: 10.1007/s40368-021-00630-5
pii: 10.1007/s40368-021-00630-5
doi:
Substances chimiques
Caseins
0
Fluorides, Topical
0
casein phosphopeptide-amorphous calcium phosphate nanocomplex
0
Fluorides
Q80VPU408O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
79-87Informations de copyright
© 2021. European Academy of Paediatric Dentistry.
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