Molecular allergology and its impact in specific allergy diagnosis and therapy.
allergen immunotherapy
component-resolved diagnosis
food allergy
major allergen
respiratory allergy
Journal
Allergy
ISSN: 1398-9995
Titre abrégé: Allergy
Pays: Denmark
ID NLM: 7804028
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
19
05
2021
received:
31
03
2021
accepted:
25
05
2021
pubmed:
1
6
2021
medline:
8
3
2022
entrez:
31
5
2021
Statut:
ppublish
Résumé
Progressive knowledge of allergenic structures resulted in a broad availability of allergenic molecules for diagnosis. Component-resolved diagnosis allowed a better understanding of patient sensitization patterns, facilitating allergen immunotherapy decisions. In parallel to the discovery of allergenic molecules, there was a progressive development of a regulation framework that affected both in vitro diagnostics and Allergen Immunotherapy products. With a progressive understanding of underlying mechanisms associated to Allergen immunotherapy and an increasing experience of application of molecular diagnosis in daily life, we focus in analyzing the evidences of the value provided by molecular allergology in daily clinical practice, with a focus on Allergen Immunotherapy decisions.
Substances chimiques
Allergens
0
Immunoglobulin E
37341-29-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3642-3658Subventions
Organisme : Medical Research Council
ID : G0902018
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M008517/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T032081/1
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
Références
Bonertz A, Roberts GC, Hoefnagel M, et al. Challenges in the implementation of EAACI guidelines on allergen immunotherapy: A global perspective on the regulation of allergen products. Allergy. 2018;73(1):64-76.
Bonertz A, Roberts G, Slater JE, et al. Allergen manufacturing and quality aspects for allergen immunotherapy in Europe and the United States: an analysis from the EAACI AIT Guidelines Project. Allergy. 2018;73(4):816-826.
van Ree R, Chapman MD, Ferreira F, et al. The CREATE project: development of certified reference materials for allergenic products and validation of methods for their quantification. Allergy. 2008;63(3):310-326.
Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, et al. EAACI molecular allergology user's guide. Pediatr Allergy Immunol. 2016;27(Suppl 23):1-250.
Barker-Tejeda TC, Bazire R, Obeso D, et al. Exploring novel systemic biomarker approaches in grass-pollen sublingual immunotherapy using omics. Allergy. 2021;76:1199-1212.
Sokolowska M, Boonpiyathad T, Escribese MM, Barber D. Allergen-specific immunotherapy: power of adjuvants and novel predictive biomarkers. Allergy. 2019;74(11):2061-2063.
Barber D, Villasenor A, Escribese MM. Metabolomics strategies to discover new biomarkers associated to severe allergic phenotypes. Asia Pac Allergy. 2019;9(4):e37.
Sanchez-Solares J, Delgado-Dolset MI, Mera-Berriatua L, et al. Respiratory allergies with no associated food allergy disrupt oral mucosa integrity. Allergy. 2019;74(11):2261-2265.
Obeso D, Mera-Berriatua L, Rodríguez-Coira J, et al. Multi-omics analysis points to altered platelet functions in severe food-associated respiratory allergy. Allergy. 2018;73(11):2137-2149.
Rosace D, Gomez-Casado C, Fernandez P, et al. Profilin-mediated food-induced allergic reactions are associated with oral epithelial remodeling. J Allergy Clin Immunol. 2019;143(2):681-690.e681.
Eguiluz-Gracia I, Tay TR, Hew M, et al. Recent developments and highlights in biomarkers in allergic diseases and asthma. Allergy. 2018;73(12):2290-2305.
Barber D, Rico P, Blanco C, Fernandez-Rivas M, Ibanez MD, Escribese MM. GRAZAX(R): a sublingual immunotherapy vaccine for Hay fever treatment: from concept to commercialization. Hum Vaccin Immunother. 2019;15(12):2887-2895.
Varona R, Ramos T, Escribese MM, et al. Persistent regulatory T-cell response 2 years after 3 years of grass tablet SLIT: Links to reduced eosinophil counts, sIgE levels, and clinical benefit. Allergy. 2019;74(2):349-360.
Suarez-Fueyo A, Ramos T, Galan A, et al. Grass tablet sublingual immunotherapy downregulates the TH2 cytokine response followed by regulatory T-cell generation. J Allergy Clin Immunol. 2014;133(1):130-138.e131-132.
van de Veen W, Akdis M. Tolerance mechanisms of allergen immunotherapy. Allergy. 2020;75(5):1017-1018.
Satitsuksanoa P, van de Veen W, Akdis M. B-cell responses in allergen immunotherapy. Curr Opin Allergy Clin Immunol. 2019;19(6):632-639.
Jansen K, Cevhertas L, Ma S, Satitsuksanoa P, Akdis M, van de Veen W. Regulatory B cells, A to Z. Allergy. 2021;76(9):2699-2715.
Ma S, Satitsuksanoa P, Jansen K, Cevhertas L, van de Veen W, Akdis M. B regulatory cells in allergy. Immunol Rev. 2021;299(1):10-30.
Eljaszewicz A, Ruchti F, Radzikowska U, et al. Trained immunity and tolerance in innate lymphoid cells, monocytes, and dendritic cells during allergen-specific immunotherapy. J Allergy Clin Immunol. 2021;147s:1865-1877.
Ansotegui JI, Melioli F, Canonica GW, et al. A WAO - ARIA - GA(2)LEN consensus document on molecular-based allergy diagnosis (PAMD@): Update 2020. World Allergy Organ J. 2020;13(2):100091.
Goodman RE, Breiteneder H. The WHO/IUIS allergen nomenclature. Allergy. 2019;74(3):429-431.
Costa J, Bavaro SL, Benedé S, et al. Are physicochemical properties shaping the allergenic potency of plant allergens? Clin Rev Allergy Immunol. 2020. https://doi.org/10.1007/s12016-020-08810-9. Online ahead of print.
Costa J, Villa C, Verhoeckx K, et al. Are physicochemical properties shaping the allergenic potency of animal allergens? Clin Rev Allergy Immunol. 2021. https://doi.org/10.1007/s12016-020-08826-1. Online ahead of print.
Kaul S, Zimmer J, Dehus O, et al. Validation of ELISA methods for quantification of the major birch allergen Bet v 1 (BSP090). Pharmeur Bio Sci Notes. 2017;2017:69-87.
Kaul S, Zimmer J, Dehus O, et al. Standardization of allergen products: 3. Validation of candidate European Pharmacopoeia standard methods for quantification of major birch allergen Bet v 1. Allergy. 2016;71(10):1414-1424.
Vieths S, Barber D, Chapman M, et al. Establishment of recombinant major allergens Bet v 1 and Phl p 5a as Ph. Eur. reference standards and validation of ELISA methods for their measurement. Results from feasibility studies. Pharmeur Bio Sci Notes. 2012;2012:118-134.
Nolte M, Barber D, Maloney J, et al. Timothy specific IgE levels are associated with efficacy and safety of timothy grass sublingual immunotherapy tablet. Ann Allergy Asthma Immunol. 2015;115(6):509-515.e502.
Duffort O, Palomares O, Lombardero M, et al. Variability of Ole e 9 allergen in olive pollen extracts: relevance of minor allergens in immunotherapy treatments. Int Arch Allergy Immunol. 2006;140(2):131-138.
Barber D, Moreno C, Ledesma A, et al. Degree of olive pollen exposure and sensitization patterns. Clinical implications. J Investig Allergol Clin Immunol. 2007;17(Suppl 1):11-16.
Hatzler L, Panetta V, Lau S, et al. Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever. J Allergy Clin Immunol. 2012;130(4):894-901.e895.
Posa D, Perna S, Resch Y, et al. Evolution and predictive value of IgE responses toward a comprehensive panel of house dust mite allergens during the first 2 decades of life. J Allergy Clin Immunol. 2017;139(2):541-549.e548.
Custovic A, Sonntag HJ, Buchan IE, Belgrave D, Simpson A, Prosperi MCF. Evolution pathways of IgE responses to grass and mite allergens throughout childhood. J Allergy Clin Immunol. 2015;136(6):1645-1652.e1648.
Matricardi PM. Allergen-specific immunoprophylaxis: toward secondary prevention of allergic rhinitis? Pediatr Allergy Immunol. 2014;25(1):15-18.
Lund G, Brand S, Ramos T, et al. Strong and frequent T-cell responses to the minor allergen Phl p 12 in Spanish patients IgE-sensitized to Profilins. Allergy. 2018;73(5):1013-1021.
Barber D, de la Torre F, Feo F, et al. Understanding patient sensitization profiles in complex pollen areas: a molecular epidemiological study. Allergy. 2008;63(11):1550-1558.
Barber D, de la Torre F, Lombardero M, et al. Component-resolved diagnosis of pollen allergy based on skin testing with profilin, polcalcin and lipid transfer protein pan-allergens. Clin Exp Allergy. 2009;39(11):1764-1773.
Cipriani F, Mastrorilli C, Tripodi S, et al. Diagnostic relevance of IgE sensitization profiles to eight recombinant Phleum pratense molecules. Allergy. 2018;73(3):673-682.
Hernández-Ramírez G, Pazos-Castro D, Gómez Torrijos E, et al. Group 1 allergens, transported by mold spores, induce asthma exacerbation in a mouse model. Allergy. 2020;75(9):2388-2391.
Asero R, Monsalve R, Barber D. Profilin sensitization detected in the office by skin prick test: a study of prevalence and clinical relevance of profilin as a plant food allergen. Clin Exp Allergy. 2008;38(6):1033-1037.
Ruiz-Garcia M, Garcia Del Potro M, Fernandez-Nieto M, Barber D, Jimeno-Nogales L, Sastre J. Profilin: a relevant aeroallergen? J Allergy Clin Immunol. 2011;128(2):416-418.
Alvarado MI, Jimeno L, De La Torre F, et al. Profilin as a severe food allergen in allergic patients overexposed to grass pollen. Allergy. 2014;69(12):1610-1616.
Rodríguez del Río P, Díaz-Perales A, Sánchez-García S, et al. Profilin, a change in the paradigm. J Investig Allergol Clin Immunol. 2018;28(1):1-12.
Matricardi PM. IgE to cross-reactive carbohydrate determinants: Origins, functions, and confounding role in nPhl p 4-IgE assays. J Allergy Clin Immunol. 2020;145(6):1554-1555.
Salcedo G, Sanchez-Monge R, Barber D, Diaz-Perales A. Plant non-specific lipid transfer proteins: an interface between plant defence and human allergy. Biochim Biophys Acta. 2007;1771(6):781-791.
Skypala IJ, Bartra J, Ebo DG, et al. The diagnosis and management of allergic reactions in patients sensitized to non-specific Lipid Transfer Proteins. Allergy. 2021;76(8):2433-2446.
Fernández-Rivas M, Garrido Fernández S, Nadal JA, et al. Randomized double-blind, placebo-controlled trial of sublingual immunotherapy with a Pru p 3 quantified peach extract. Allergy. 2009;64(6):876-883.
Gomez F, Bogas G, Gonzalez M, et al. The clinical and immunological effects of Pru p 3 sublingual immunotherapy on peach and peanut allergy in patients with systemic reactions. Clin Exp Allergy. 2017;47(3):339-350.
Palomares F, Gomez F, Bogas G, et al. Immunological changes induced in peach allergy patients with systemic reactions by Pru p 3 sublingual immunotherapy. Mol Nutr Food Res. 2018;62(3):1700669.
Biedermann T, Winther L, Till SJ, Panzner P, Knulst A, Valovirta E. Birch pollen allergy in Europe. Allergy. 2019;74(7):1237-1248.
Biedermann T, Kuna P, Panzner P, et al. The SQ tree SLIT-tablet is highly effective and well tolerated: Results from a randomized, double-blind, placebo-controlled phase III trial. J Allergy Clin Immunol. 2019;143(3):1058-1066.e1056.
Nolte H, Waserman S, Ellis AK, Biedermann T, Wurtzen PA. Treatment effect of the tree pollen SLIT-tablet on allergic rhinoconjunctivitis during oak pollen season. J Allergy Clin Immunol Pract. 2021;9:1871-1878.
Würtzen PA, Grønager PM, Lund G, et al. Simplified AIT for allergy to several tree pollens-Arguments from the immune outcome analyses following treatment with SQ tree SLIT-tablet. Clin Exp Allergy. 2021;51(2):284-295.
van der Valk JPM, Nagl B, van Wljk RG, Bohle B, de Jong NW. The effect of birch pollen immunotherapy on apple and rMal d 1 challenges in adults with apple allergy. Nutrients. 2020;12(2):519.
Till SJ, Stage BS, Skypala I, Biedermann T. Potential treatment effect of the SQ tree SLIT-tablet on pollen food syndrome caused by apple. Allergy. 2020;75(8):2059-2061.
Sanchez Acosta G, Kinaciyan T, Kitzmuller C, Mobs C, Pfutzner W, Bohle B. IgE-blocking antibodies following SLIT with recombinant Mal d 1 accord with improved apple allergy. J Allergy Clin Immunol. 2020;146(4):894-900.e892.
Okamoto Y, Okubo K, Yonekura S, et al. Efficacy and safety of sublingual immunotherapy for two seasons in patients with Japanese cedar pollinosis. Int Arch Allergy Immunol. 2015;166(3):177-188.
Gotoh M, Yonekura S, Imai T, et al. Long-term efficacy and dose-finding trial of Japanese cedar pollen sublingual immunotherapy tablet. J Allergy Clin Immunol Pract. 2019;7(4):1287-1297.e1288.
Alvaro-Lozano M, Akdis CA, Akdis M, et al. EAACI allergen immunotherapy user's guide. Pediatr Allergy Immunol. 2020;31(Suppl 25):1-101.
Christensen LH, Ipsen H, Nolte H, et al. Short ragweeds is highly cross-reactive with other ragweeds. Ann Allergy Asthma Immunol. 2015;115(6):490-495.e491.
Creticos PS, Maloney J, Bernstein DI, et al. Randomized controlled trial of a ragweed allergy immunotherapy tablet in North American and European adults. J Allergy Clin Immunol. 2013;131(5):1342-1349.e1346.
Nolte H, Bernstein DI, Nelson HS, Ellis AK, Kleine-Tebbe J, Lu S. Efficacy and safety of ragweed SLIT-tablet in children with allergic rhinoconjunctivitis in a randomized, placebo-controlled trial. J Allergy Clin Immunol Pract. 2020;8(7):2322-2331.e2325.
Uriarte SA, Sastre J. Clinical relevance of molecular diagnosis in pet allergy. Allergy. 2016;71(7):1066-1068.
Ukleja-Sokołowska N, Gawrońska-Ukleja E, Żbikowska-Gotz M, et al. Analysis of feline and canine allergen components in patients sensitized to pets. Allergy Asthma Clin Immunol. 2016;12:61.
Nordlund B, Konradsen JR, Kull I, et al. IgE antibodies to animal-derived lipocalin, kallikrein and secretoglobin are markers of bronchial inflammation in severe childhood asthma. Allergy. 2012;67(5):661-669.
Schoos AM, Nwaru BI, Borres MP. Component-resolved diagnostics in pet allergy: current perspectives and future directions. J Allergy Clin Immunol. 2021;147(4):1164-1173.
Uriarte SA, Gronlund H, Wintersand A, Bronge J, Sastre J. Clinical and immunologic changes due to subcutaneous immunotherapy with cat and dog extracts using an ultrarush up-dosing phase: a real-life study. J Investig Allergol Clin Immunol. 2020;32. Online ahead of print.
Asarnoj A, Hamsten C, Waden K, et al. Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study. J Allergy Clin Immunol. 2016;137(3):813-821.e817.
Nanda A, O'Connor M, Anand M, et al. Dose dependence and time course of the immunologic response to administration of standardized cat allergen extract. J Allergy Clin Immunol. 2004;114(6):1339-1344.
Wintersand A, Asplund K, Binnmyr J, et al. Allergens in dog extracts: Implication for diagnosis and treatment. Allergy. 2019;74(8):1472-1479.
Lent AM, Harbeck R, Strand M, et al. Immunologic response to administration of standardized dog allergen extract at differing doses. J Allergy Clin Immunol. 2006;118(6):1249-1256.
Uriarte SA, Sastre J. Subcutaneous immunotherapy with high-dose cat and dog extracts: a real-life study. J Investig Allergol Clin Immunol. 2020;30(3):169-174.
Uriarte S, Sastre J. Safety of an Ultrarush (4 hours) subcutaneous immunotherapy schedule with cat and dog extracts using an infusion pump. J Investig Allergol Clin Immunol. 2018;28(6):430-432.
Barber D, Arias J, Boquete M, et al. Analysis of mite allergic patients in a diverse territory by improved diagnostic tools. Clin Exp Allergy. 2012;42(7):1129-1138.
Celi G, Brusca I, Scala E, et al. House dust mite allergy in Italy-Diagnostic and clinical relevance of Der p 23 (and of minor allergens): a real-life, multicenter study. Allergy. 2019;74(9):1787-1789.
Arias-Irigoyen J, Lombardero M, Arteaga C, Carpizo JA, Barber D. Limited IgE cross-reactivity between Dermatophagoides pteronyssinus and Glycyphagus domesticus in patients naturally exposed to both mite species. J Allergy Clin Immunol. 2007;120(1):98-104.
Blanco C, Quiralte J, Castillo R, et al. Anaphylaxis after ingestion of wheat flour contaminated with mites. J Allergy Clin Immunol. 1997;99(3):308-313.
Arroabarren E, Echechipia S, Galbete A, Lizaso MT, Olaguibel JM, Tabar AI. Association between component-resolved diagnosis of house dust mite allergy and efficacy and safety of specific immunotherapy. J Investig Allergol Clin Immunol. 2019;29(2):164-167.
Rodríguez-Domínguez A, Berings M, Rohrbach A, et al. Molecular profiling of allergen-specific antibody responses may enhance success of specific immunotherapy. J Allergy Clin Immunol. 2020;146(5):1097-1108.
Tripodi S, Frediani T, Lucarelli S, et al. Molecular profiles of IgE to Phleum pratense in children with grass pollen allergy: implications for specific immunotherapy. J Allergy Clin Immunol. 2012;129(3):834-839.e838.
Weinstock GM, Robinson GE, Gibbs RA, et al. Insights into social insects from the genome of the honeybee Apis mellifera. Nature. 2006;443(7114):931-949.
Peiren N, Vanrobaeys F, de Graaf DC, Devreese B, Van Beeumen J, Jacobs FJ. The protein composition of honeybee venom reconsidered by a proteomic approach. Biochim Biophys Acta. 2005;1752(1):1-5.
Van Vaerenbergh M, Debyser G, Devreese B, de Graaf DC. Exploring the hidden honeybee (Apis mellifera) venom proteome by integrating a combinatorial peptide ligand library approach with FTMS. J Proteomics. 2014;99:169-178.
Radauer C, Nandy A, Ferreira F, et al. Update of the WHO/IUIS Allergen Nomenclature Database based on analysis of allergen sequences. Allergy. 2014;69(4):413-419.
Spillner E, Blank S, Jakob T. Hymenoptera allergens: from venom to “venome”. Front Immunol. 2014;5:77.
Frick M, Fischer J, Helbling A, et al. Predominant Api m 10 sensitization as risk factor for treatment failure in honey bee venom immunotherapy. J Allergy Clin Immunol. 2016;138(6):1663-1671.e1669.
Kohler J, Blank S, Muller S, et al. Component resolution reveals additional major allergens in patients with honeybee venom allergy. J Allergy Clin Immunol. 2014;133(5):1383-1389, 1389.e1381-1386.
Blank S, Bantleon FI, McIntyre M, Ollert M, Spillner E. The major royal jelly proteins 8 and 9 (Api m 11) are glycosylated components of Apis mellifera venom with allergenic potential beyond carbohydrate-based reactivity. Clin Exp Allergy. 2012;42(6):976-985.
Blank S, Seismann H, McIntyre M, et al. Vitellogenins are new high molecular weight components and allergens (Api m 12 and Ves v 6) of Apis mellifera and Vespula vulgaris venom. PLoS One. 2013;8(4):e62009.
Michel Y, McIntyre M, Ginglinger H, et al. The putative serine protease inhibitor Api m 6 from Apis mellifera venom: recombinant and structural evaluation. J Investig Allergol Clin Immunol. 2012;22(7):476-484.
Ruiz B, Serrano P, Verdu M, Moreno C. Sensitization to Api m 1, Api m 2, and Api m 4: association with safety of bee venom immunotherapy. Ann Allergy Asthma Immunol. 2015;114(4):350-352.
King TP, Spangfort MD. Structure and biology of stinging insect venom allergens. Int Arch Allergy Immunol. 2000;123(2):99-106.
Muller UR. Recombinant Hymenoptera venom allergens. Allergy. 2002;57(7):570-576.
Kolarich D, Leonard R, Hemmer W, Altmann F. The N-glycans of yellow jacket venom hyaluronidases and the protein sequence of its major isoform in Vespula vulgaris. FEBS J. 2005;272(20):5182-5190.
Seismann H, Blank S, Braren I, et al. Dissecting cross-reactivity in hymenoptera venom allergy by circumvention of alpha-1,3-core fucosylation. Mol Immunol. 2010;47(4):799-808.
Blank S, Seismann H, Bockisch B, et al. Identification, recombinant expression, and characterization of the 100 kDa high molecular weight Hymenoptera venom allergens Api m 5 and Ves v 3. J Immunol. 2010;184(9):5403-5413.
Cifuentes L, Vosseler S, Blank S, et al. Identification of Hymenoptera venom-allergic patients with negative specific IgE to venom extract by using recombinant allergens. J Allergy Clin Immunol. 2014;133(3):909-910.
Ebo DG, Faber M, Sabato V, Leysen J, Bridts CH, De Clerck LS. Component-resolved diagnosis of wasp (yellow jacket) venom allergy. Clin Exp Allergy. 2013;43(2):255-261.
Korošec P, Valenta R, Mittermann I, et al. High sensitivity of CAP-FEIA rVes v 5 and rVes v 1 for diagnosis of Vespula venom allergy. J Allergy Clin Immunol. 2012;129(5):1406-1408.
Mittermann I, Zidarn M, Silar M, et al. Recombinant allergen-based IgE testing to distinguish bee and wasp allergy. J Allergy Clin Immunol. 2010;125(6):1300-1307.e1303.
Seismann H, Blank S, Cifuentes L, et al. Recombinant phospholipase A1 (Ves v 1) from yellow jacket venom for improved diagnosis of hymenoptera venom hypersensitivity. Clin Mol Allergy. 2010;8:7.
Vos B, Kohler J, Muller S, Stretz E, Rueff F, Jakob T. Spiking venom with rVes v 5 improves sensitivity of IgE detection in patients with allergy to Vespula venom. J Allergy Clin Immunol. 2013;131(4):1225-1227, 1227.e1221.
Hofmann SC, Pfender N, Weckesser S, Huss-Marp J, Jakob T. Added value of IgE detection to rApi m 1 and rVes v 5 in patients with Hymenoptera venom allergy. J Allergy Clin Immunol. 2011;127(1):265-267.
Muller UR, Johansen N, Petersen AB, Fromberg-Nielsen J, Haeberli G. Hymenoptera venom allergy: analysis of double positivity to honey bee and Vespula venom by estimation of IgE antibodies to species-specific major allergens Api m1 and Ves v5. Allergy. 2009;64(4):543-548.
Jin C, Focke M, Leonard R, Jarisch R, Altmann F, Hemmer W. Reassessing the role of hyaluronidase in yellow jacket venom allergy. J Allergy Clin Immunol. 2010;125(1):184-190.e181.
Monsalve RI, Vega A, Marqués L, et al. Component-resolved diagnosis of vespid venom-allergic individuals: phospholipases and antigen 5s are necessary to identify Vespula or Polistes sensitization. Allergy. 2012;67(4):528-536.
Schiener M, Hilger C, Eberlein B, et al. The high molecular weight dipeptidyl peptidase IV Pol d 3 is a major allergen of Polistes dominula venom. Sci Rep. 2018;8(1):1318.
Michel J, Brockow K, Darsow U, et al. Added sensitivity of component-resolved diagnosis in hymenoptera venom-allergic patients with elevated serum tryptase and/or mastocytosis. Allergy. 2016;71(5):651-660.
Vickery BP, Vereda A, Casale TB, et al. AR101 oral immunotherapy for peanut allergy. N Engl J Med. 2018;379(21):1991-2001.
O'B Hourihane J, Beyer K, Abbas A, et al. Efficacy and safety of oral immunotherapy with AR101 in European children with a peanut allergy (ARTEMIS): a multicentre, double-blind, randomised, placebo-controlled phase 3 trial. Lancet Child Adolesc Health. 2020;4(10):728-739.
Wang J. Advances in the management of peanut allergy (oral immunotherapy and epicutaneous immunotherapy). Allergy Asthma Proc. 2020;41(1):5-9.
Foong RX, Dantzer JA, Wood RA, Santos AF. Improving diagnostic accuracy in food allergy. J Allergy Clin Immunol Pract. 2021;9(1):71-80.
Santos AF, Barbosa-Morais NL, Hurlburt BK, et al. IgE to epitopes of Ara h 2 enhance the diagnostic accuracy of Ara h 2-specific IgE. Allergy. 2020;75:2309-2318.
Santos AF, Du Toit G, O'Rourke C, et al. Biomarkers of severity and threshold of allergic reactions during oral peanut challenges. J Allergy Clin Immunol. 2020;146(2):344-355.
Santos AF. Food allergy severity prediction: quite a way to go yet? Expert Rev Clin Immunol. 2020;16(6):543-546.
Hemmings O, Du Toit G, Radulovic S, Lack G, Santos AF. Ara h 2 is the dominant peanut allergen despite similarities with Ara h 6. J Allergy Clin Immunol. 2020;146(3):621-630.e625.
Sastre J, Rodriguez F, Campo P, Laffond E, Marin A, Alonso MD. Adverse reactions to immunotherapy are associated with different patterns of sensitization to grass allergens. Allergy. 2015;70(5):598-600.
Calderon MA, Simons FE, Malling HJ, Lockey RF, Moingeon P, Demoly P. Sublingual allergen immunotherapy: mode of action and its relationship with the safety profile. Allergy. 2012;67(3):302-311.
Valenta R, Lidholm J, Niederberger V, Hayek B, Kraft D, Gronlund H. The recombinant allergen-based concept of component-resolved diagnostics and immunotherapy (CRD and CRIT). Clin Exp Allergy. 1999;29(7):896-904.
Matricardi PM, Dramburg S, Potapova E, Skevaki C, Renz H. Molecular diagnosis for allergen immunotherapy. J Allergy Clin Immunol. 2019;143(3):831-843.
Canonica GW, Bachert C, Hellings P, et al. Allergen Immunotherapy (AIT): a prototype of Precision Medicine. World Allergy Organ J. 2015;8(1):31.
Matricardi PM, Kleine-Tebbe J. Molecular allergology between precision medicine and the choosing wisely initiative. Clin Exp Allergy. 2016;46(5):664-667.
Di Fraia M, Arasi S, Castelli S, et al. A new molecular multiplex IgE assay for the diagnosis of pollen allergy in Mediterranean countries: a validation study. Clin Exp Allergy. 2019;49(3):341-349.
Matricardi PM, Potapova E, Forchert L, Dramburg S, Tripodi S. Digital allergology: towards a clinical decision support system for allergen immunotherapy. Pediatr Allergy Immunol. 2020;31(Suppl 24):61-64.
Kleine-Tebbe J, Matricardi PM, Hamilton RG. Allergy work-up including component-resolved diagnosis: how to make allergen-specific immunotherapy more specific. Immunol Allergy Clin North Am. 2016;36(1):191-203.
Sastre J, Landivar ME, Ruiz-Garcia M, Andregnette-Rosigno MV, Mahillo I. How molecular diagnosis can change allergen-specific immunotherapy prescription in a complex pollen area. Allergy. 2012;67(5):709-711.
Sastre J, Sastre-Ibanez M. Molecular diagnosis and immunotherapy. Curr Opin Allergy Clin Immunol. 2016;16(6):565-570.
Agache I, Lau S, Akdis CA, et al. EAACI guidelines on allergen immunotherapy: house dust mite-driven allergic asthma. Allergy. 2019;74(5):855-873.
Pajno GB, Fernandez-Rivas M, Arasi S, et al. EAACI Guidelines on allergen immunotherapy: IgE-mediated food allergy. Allergy. 2018;73(4):799-815.
Barber D, Diaz-Perales A, Villalba M, Chivato T. Challenges for allergy diagnosis in regions with complex pollen exposures. Curr Allergy Asthma Rep. 2015;15(2):496.
Shamji MH, Akdis CA, Barber D, et al. EAACI research and outreach committee: improving standards and facilitating global collaboration through a research excellence network. Allergy. 2020;75(8):1899-1901.
Gomez-Casado C, Villasenor A, Rodriguez-Nogales A, Bueno JL, Barber D, Escribese MM. Understanding platelets in infectious and allergic lung diseases. Int J Mol Sci. 2019;20(7):1730.
Blank S, Bilo MB, Ollert M. Component-resolved diagnostics to direct in venom immunotherapy: important steps towards precision medicine. Clin Exp Allergy. 2018;48(4):354-364.