Long-term control of diabetes in a nonhuman primate by two separate transplantations of porcine adult islets under immunosuppression.
animal models: nonhuman primate
basic (laboratory) research/science
endocrinology/diabetology
islet transplantation
translational research/science
xenoantigen
xenotransplantation
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
29
04
2021
received:
27
10
2020
accepted:
24
05
2021
pubmed:
1
6
2021
medline:
12
11
2021
entrez:
31
5
2021
Statut:
ppublish
Résumé
Porcine islet transplantation is an alternative to allo-islet transplantation. Retransplantation of islets is a routine clinical practice in islet allotransplantation in immunosuppressed recipients and will most likely be required in islet xenotransplantation in immunosuppressed recipients. We examined whether a second infusion of porcine islets could restore normoglycemia and further evaluated the efficacy of a clinically available immunosuppression regimen including anti-thymocyte globulin for induction; belimumab, sirolimus, and tofacitinib for maintenance and adalimumab, anakinra, IVIg, and tocilizumab for inflammation control in a pig to nonhuman primate transplantation setting. Of note, all nonhuman primates were normoglycemic after the retransplantation of porcine islets without induction therapy. Graft survival was >100 days for all 3 recipients, and 1 of the 3 monkeys showed insulin independence for >237 days. Serious lymphodepletion was not observed, and rhesus cytomegalovirus reactivation was controlled without any serious adverse effects throughout the observation period in all recipients. These results support the clinical applicability of additional infusions of porcine islets. The maintenance immunosuppression regimen we used could protect the reinfused islets from acute rejection.
Identifiants
pubmed: 34058060
doi: 10.1111/ajt.16704
pii: S1600-6135(22)08789-5
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3561-3572Informations de copyright
© 2021 The American Society of Transplantation and the American Society of Transplant Surgeons.
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